Short-chain fructo-oligosaccharides (SC-FOS) are a mixture of oligosaccharides consisting of glucose linked to fructose units (Gfn; n =

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BackgroundThe interest in natural antioxidants, especially polyphenols, is growing more and more thanks to their positive contribution to human health. Thus, the prevention from the harmful action of oxidative stress which has been involved in many diseases such as cancer, inflammation diabetes, and cardiovascular illness.Recent research proved the bioactive compounds richness of date seeds which could be a good biological matrix of natural antioxidants. Unfortunately, an important quantity of Tunisian dates seed is discarded yearly.MethodsIn this study, different solvents extraction (water, methanol, absolute acetone and aqueous acetone 80%) were used and the evaluation of its effect on phytochemical level, in vitro antioxidant activities, in vitro hyperglycemia key enzymes inhibition and in vivo anti-inflammatory proprieties were established for Tunisian date seeds.ResultsThe result revealed that the polar solvent exhibited the highest amount of bioactive compounds. The correlation between polyphenol compounds and the antioxidant potentiality explains the powerful effect of used polar solvents on inflammation, TBARS and hyperglycemia inhibition. Furthermore, it showed its higher capacity to scavenge radicals.ConclusionsTherefore, this big waste of Tunisian seeds could be used as cheap source of natural antioxidant compounds which are considered as a health challenge for the poor countries.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-017-1751-y) contains supplementary material, which is available to authorized users.

Date pulp and seeds (Phoenix dactylifera L.) of a mixture of some mature common varieties called 'Khalti', from the South-Eastern region of Tunisia, were evaluated for their main chemical composition. Studies were also conducted on the profiles of the extracted oil fatty acid. The following average values (on a dry-weight basis) were obtained from the pulp and pits, respectively: total sugars 63.38% and 8.12%, reducing sugars 51.56% and 6.63%, sucrose 11.82% and 1.49%, protein 3.86% and 5.31%, oil 0.26% and 8.33%. Gasliquid chromatography revealed that the major unsaturated fatty acid was linoleic acid (32.77%) for the pulp and oleic acid (47.66%) for the pits, while the main saturated fatty acid was palmitic acid (20.55%) for the pulp and lauric acid (17.39%) for the pits. Myristic, stearic and linolenic acids were also found in both the pulp and seeds. The uses of common dates, which are currently used only for animal feed, are assessed with suggestions for potential uses as sources of nutraceutical fructose and edible, pharmaceutical oils.