Protective effect of date palm fruit extract (Phoenix dactylifera L.) on dimethoate induced-oxidative stress in rat liver

Saafi, Emna Behija; Louedi, Mouna; Elfeki, Abdelfattah; Zakhama, Abdelfattah; Najjar, Mohamed Fadhel; Hammami, Mohamed; Achour, Lotfi

doi:10.1016/j.etp.2010.03.002

Cited by 181 publications

(150 citation statements)

References 57 publications

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“…Tunisian dates were recently demonstrated to have antioxidant capacity 8 as well as a protective effect on dimethoate-induced oxidative stress in rat liver. 34 Concerning the mechanism of action of the dates pulp extract, we showed in this work its richness in minerals and sugars, especially potassium and reduced sugars. However, the mineral content in the digestive system can affect the processes of secretion and gastrointestinal absorption of water and electrolytes.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dates Pulp Extract and Palm Sap (Phoenix dactylifera L.) on Gastrointestinal Transit Activity in Healthy Rats

Souli

Sebaï²,

Rtibi³

et al. 2014

Journal of Medicinal Food

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The current study was performed to measure the chemical composition and the effects of dates pulp extract and palm sap on gastrointestinal transit (GIT) activity in healthy adult rats. In this respect, male Wistar rats fasted for 24 hours were used and received per orally (p.o.) sodium chloride (NaCl) (0,9%) (control group) or various doses of dates pulp extract (150 and 300 mg/kg, body weight [b.w.]) and palm sap (0.4 and 4 mL/kg, b.w.). Two other groups of rats (batch tests) received, respectively, clonidine (an alpha-2 adrenergic agonist, 1 mg/kg, b.w.) and yohimbine (an alpha-2 adrenergic antagonist, 2mg/kg, b.w.). Chemical analysis showed that the dates pulp extract is more rich in sugars and minerals, especially potassium and sucrose, as compared with palm sap composition. On the other hand, in vivo study showed that the aqueous dates pulp extract significantly, and dose dependently, increased the GIT activity while the palm sap slightly increased it. Moreover, a converse effect has been observed using clonidine (decreased 68%) and yohimbine (increased 33%) on the GIT activity. These findings suggest that dates pulp extract and palm sap have a stimulating effect on GIT activity in rats and confirm their use in traditional Tunisian medicine for the treatment of constipation.

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Section: Discussionmentioning

confidence: 99%

Effects of Dates Pulp Extract and Palm Sap (Phoenix dactylifera L.) on Gastrointestinal Transit Activity in Healthy Rats

Souli

Sebaï²,

Rtibi³

et al. 2014

Journal of Medicinal Food

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“…Its extract was found to exhibit strong antimicrobial activity against various types of microorganisms such as, bacteria (Saddiq and Bawazir, 2010), fungi (Shraideh et al, 1998) and viruses (Jassim and Naji, 2010). Also, date palm extract was found to have a strong hepatoprotective activity against various harmful toxicants (Saafi et al, 2011;Al-Qarawi et al, 2005) from results obtained from histological and biochemical measurements. The present study has been designed to investigate the ameliorative effect of date fruit extract on the hepatic injury-mediated by the intestinal coccidian parasite, E. papillata.…”

Section: Introductionmentioning

confidence: 98%

“…The third group was orally inoculated with 1.5 x 10 3 sporulated E. papillata oocysts and after 1 h treated with (20%) aqueous extract of date palm in a dose of 4 ml/kg and the dose was repeated for four successive days. The dose and the route of injection were selected on the basis of the previous studies (Al-Qarawi et al, 2005;Saafi et al, 2011).…”

Section: Experimental Designmentioning

confidence: 99%

Role of Phoenix dactylifera in ameliorating Eimeria papillata-induced hepatic injury in mice

Metwaly¹

2012

J. Med. Plants Res.

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Phoenix dactylifera (Date) is used in traditional medicine for its pharmacological properties. Here, we investigated the effects of Kodary date fruit on the outcome of coccidiosis caused by Eimeria papillata in mice. Coccidiosis was induced by infection of mice with 1.5 × 10 3 sporulated oocysts of E. papillata. The aqueous extract of date fruit (4 ml/kg) was used in vivo for its hepatoprotective properties. Anticoccidial and anti-inflammatory activities of date fruit were determined through oocyst output and liver histopathology, respectively. The data showed that mice infected with E. papillata revealed an output of about 8.7 × 10 3 oocysts per gram faeces on day 4 post -inoculation (p.i.). This output significantly decreased to about 6.7 × 10 3 oocysts in date fruit-treated mice. Infection caused a marked liver injury as indicated by histopathological alterations as well as the significant increase in liver glutamic pyruvate transaminase (GPT) and alkaline phosphatase (ALP). Also, infection induced a significant increase in total protein and total lipids. The aqueous extract of P. dactylifera fruit showed a significant (P 0.05) hepatoprotective potential by improving the aforementioned parameters. Based on these results, it is concluded that date fruit could offer protection against hepatotoxicity as well as ameliorate preexisting liver damage.

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“…The rats were divided randomly into six groups consisting of ten animals each and were applied with oral gavage during sixty days as follow: Group I (controls) received only saline; group II (D) was exposed to dimethoate; group III (LOFE) was applied with only L. officinalis fruit extract; group IV (LOFE + D) received L. officinalis fruit extract 30 min prior to dimethoate; group V (Vit C + D) was given vitamin C 30 min before dimethoate; group VI (D + LOFE) BALDEMİR, YAY, CANTÜRK received dimethoate during the first month, the rats were exposed to dimethoate 30 min prior to L. officinalis fruit extract throughout the second month. The doses for dimethoate (7 mg/kg/day) [2] , vitamin C (100 mg/kg/day) [5] , and L. officinalis fruit extract (4 mg/kg/day) [24] were determined by using the results of other studies.…”

Section: Dpph Radical Scavenging Activitymentioning

confidence: 99%

“…Producers, pesticide workers, and farm owners are the basic risk groups of dimethoate exposure [3] . Previous studies indicate that dimethoate leads to oxidative stress via production of free radicals and induction of lipid peroxidation [4][5][6] . Some studies have shown that dimethoate causes significant increase in lipid peroxidation by interacting with membrane lipids due to its lipophilic feature [7,8] .…”

Section: Introductionmentioning

confidence: 99%

Sıçanlarda Dimetoatla Oluşturulan Hepatotoksisite Üzerine Taflan (Laurocerasus officinalis Roem.) Meyvesinin Koruyucu Etkisi

Eken¹,

Endirlik²,

Baldemir³

et al. 2017

Kafkas Univ Vet Fak Derg

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Citation of This ArticleEken A, Ünlü Endirlik B, Bakır E, Baldemir A, Yay AH, Cantürk F: Effect of Laurocerasus officinalis Roem. (Cherry laurel) fruit on dimethoate induced hepatotoxicity in rats. Kafkas Univ Vet Fak Derg, 23 (5): 779-787, 2017779-787, . DOI: 10.9775/kvfd.2017 Abstract Dimethoate is one of the most important organophosphate insecticides and may cause oxidative stress leading to production of free radicals and alterations in antioxidants. The aim of this study was to investigate the protective effects of Laurocerasus officinalis Roem. fruit extract containing antioxidant compounds on dimethoate-induced hepatotoxicity in rats. The rats were divided into six groups as follows: Control group; dimethoate-treated group; L. officinalis-treated group; the group of pre-treatment with L. officinalis prior to dimethoate; the group of pre-treatment with vitamin C before dimethoate; the group of post-treatment with L. officinalis after dimethoate. Aspartate transaminase (AST), alanine transaminase (ALT), and total bilirubin (TBil) as liver function tests and the oxidative stress parameters such as total oxidant status (TOS), total antioxidant status (TAS), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and malondialdehyde (MDA) were measured. The DNA damage was determined with comet assay. The results indicated that dimethoate caused a significant increase in AST, ALT, TOS, MDA, DNA damage and an important decrease in TAS, SOD, CAT, GPx as compared to control group. However, administration of L. officinalis or vitamin C to dimethoate-exposed rats restored these biochemical and oxidative stress parameters to nearly normal levels. In conclusion, toxic effects of dimethoate on rat liver are mainly attributed to hepatic function enzymes, oxidative stress and DNA damage, while these effects were largely ameliorated by L. officinalis fruit extract. Keywords: Laurocerasus officinalis Roem, Cherry Laurel, Dimethoate, Hepatotoxicity, Rat Sıçanlarda Dimetoatla Oluşturulan Hepatotoksisite Üzerine Taflan (Laurocerasus officinalis Roem.) Meyvesinin Koruyucu Etkisi ÖzetDimetoat en önemli organofosfatlı insektisitlerden biridir, serbest radikallerin üretimine ve antioksidanlarda değişimlere yol açarak oksidatif strese neden olur. Çalışmanın amacı, ratlarda antioksidan bileşikler içeren Laurocerasus officinalis Roem. meyve ekstresinin dimetoat kaynaklı karaciğer toksisitesindeki koruyucu etkilerini incelemektir. Ratlar aşağıdaki gibi altı gruba ayrıldı: Kontrol grubu; dimetoate ile muamele edilen grup; L. officinalis ile muamele edilen grup; dimetoat öncesi L. officinalis verilen grup; dimetoat öncesi vitamin C verilen grup; dimetoat sonrası L. officinalis ile muamele edilen grup. Karaciğer fonksiyon testleri olarak aspartat transaminaz (AST), alanin transaminaz (ALT) ve toplam bilirubin (TBil) ile toplam oksidan durum (TOS), toplam antioksidan durum (TAS), süperoksit dismutaz (SOD), katalaz (CAT), glutatyon peroksidaz (GPx) ve malondialdehit (MDA) gibi oksidatif stres parametreleri ölçüldü. DNA...

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Protective effect of date palm fruit extract (Phoenix dactylifera L.) on dimethoate induced-oxidative stress in rat liver

Cited by 181 publications

References 57 publications

Effects of Dates Pulp Extract and Palm Sap (Phoenix dactylifera L.) on Gastrointestinal Transit Activity in Healthy Rats

Effects of Dates Pulp Extract and Palm Sap (Phoenix dactylifera L.) on Gastrointestinal Transit Activity in Healthy Rats

Role of Phoenix dactylifera in ameliorating Eimeria papillata-induced hepatic injury in mice

Sıçanlarda Dimetoatla Oluşturulan Hepatotoksisite Üzerine Taflan (Laurocerasus officinalis Roem.) Meyvesinin Koruyucu Etkisi

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