Sıçanlarda Dimetoatla Oluşturulan Hepatotoksisite Üzerine Taflan (Laurocerasus officinalis Roem.) Meyvesinin Koruyucu Etkisi

Eken, Ayşe; Endirlik, Burcu Ünlü; Baldemir, Ayşe; Yay, Arzu Hanım; Cantürk, Fazile

doi:10.9775/kvfd.2017.17748

Cited by 3 publications

(1 citation statement)

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“…The study identified K and Mg as the main macro minerals; and, respectively, Zn and Fe as the main micro minerals in Cape gooseberry seeds, regardless of ripeness stage. K, Na, Ca, and Mg concentrations in the study were higher than some previously reported data [9,[47][48][49], inclusive that about fruit of the same origin [50], while micro mineral contents (Fe, Mn, Cu, Zn) established no such uniform trend, being either higher or close to reported data. Those differences obviously reflected the influence of fruit ripeness discussed above (published data regarded only fully ripe fruit), but value comparison also supported the assumption that the seeds were the center of mineral accumulation in Cape gooseberry fruit, as all of the studies above considered either whole fruit or fruit pulp (fruit meal) alone.…”

Section: Minerals In the Seeds Of Unripe And Underripe Cape Gooseberr...contrasting

confidence: 68%

Effect of maturity on the phytonutrient composition of Cape gooseberry seeds (Physalis peruviana L.)

et al. 2022

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The seeds of Cape gooseberry (Physalis peruviana L.) remain as a by-product from juice production, but they can also be a potential resource of valuable nutrients. The objective of this study was to analyze the phytonutrient composition of the seeds isolated from fruit at two maturity stages unsuitable for regular realization (unripe and under-ripe), with the aim of identifying the possibility for utilization of such non-standard or discarded agricultural production. The results showed about 3-time lower oil content in the unripe seeds than in the under-ripe seeds (6.60% vs. 21.75%), but no significant differences in the content of protein (18.44% and 17.83%) and cellulose (26.63% and 26.14%). The total tocopherol content slightly decreased with the progress of fruit maturity (from 8354 mg/kg to 7118 mg/kg). Significant changes in the amino acid composition were found only with regard to aspartic acid, glutamic acid, tyrosine and methionine. The content of macro and micro minerals was lower in the under-ripe seeds (about 1.5-2-time). The results from this baseline study suggested that the seeds from both unripe and under-ripe fruit could also be considered for nutritive purposes (animal feed, food products).

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Section: Minerals In the Seeds Of Unripe And Underripe Cape Gooseberr...contrasting

confidence: 68%

Effect of maturity on the phytonutrient composition of Cape gooseberry seeds (Physalis peruviana L.)

et al. 2022

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Cherry laurel fruit extract counters dimethoate-induced reproductive impairment and testicular apoptosis

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et al. 2020

Archives of Industrial Hygiene and Toxicology

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Dimethoate is an organophosphorus pesticide used against agricultural insects, which causes oxidative stress and damage in many organs, including the reproductive ones. Cherry laurel (Laurocerasus officinalis Roem.) fruit is rich in vitamins and phenolic compounds with antioxidant effect. The aim of this study was to investigate how effective its extract would be against dimethoate-induced testis and sperm damage in rats. Sixty animals were divided in six groups of 10. Group 1 (control) received only 1 mL of saline (0.9 % NaCl). Group 2 received 7 mg/kg of dimethoate in 1 mL of saline. Group 3 received 4 mg/kg of extract in 1 mL of saline. Group 4 received the extract 30 min before dimethoate administration. Group 5 received vitamin C (positive control, 100 mg/kg in 1 mL of saline) 30 min before dimethoate administration. Group 6 received only dimethoate for the first four weeks and then a combination of dimethoate and extract for another four weeks. All doses were administered daily by oral gavage. After eight weeks of treatment, the rats were euthanised and their reproductive organs removed. We took their body and reproductive organ weights and evaluated testicular oxidative stress, semen characteristics, sperm DNA damage, testicular apoptosis, and histopathological changes. Dimethoate significantly decreased body and reproductive organ weights, sperm motility and concentration, testicular superoxide dismutase, and glutathione-peroxidase activities and significantly increased lipid peroxidation, abnormal sperm rate, sperm DNA damage, testicular apoptosis, and caused histopathological lesions. Cherry laurel extract significantly countered many dimethoate-induced adverse effects, both as pre- and post-treatment, including reproductive organ weight, semen parameters, oxidant-antioxidant balance, sperm DNA integrity, testicular apoptosis, and histological structure. Our findings clearly suggest that the beneficial effects of the extract are associated with countering oxidative stress, lipid peroxidation in particular.

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Determination of the Combined Effect of Dimethoate and Malathion Pesticides on Dreissena polymorpha (Pallas, 1771) Using Cytochrome P450 and Acetylcholinesterase

Yıldırım

Serdar

Yıldırım

2022

Journal of Anatolian Environmental and Animal Sciences

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Bu çalışmada, Dreissena polymorpha’da organofosforlu dimethoate ve malathion etken maddeli insektisit karışımlarının toksisitesini ortaya çıkarmak için sitokrom P450 (CYP1A1) ve Asetilkolinesteraz (AchE) aktiviteleri ölçülmüştür. Dimethoate ve malathion'un öldürücü konsantrasyonu (LC50) 96 saat maruziyet sonunda 40,82±2,54 mg/L olarak hesaplanmıştır. D. polymorpha dimethoate ve malathionun üç subletal konsantrasyonuna (LC50 değerine 1/16, 1/8 ve 1/4 oranla) 24 saat ve 96 saat boyunca maruz bırakılmıştır. CYP1A1 ve AChE seviyeleri, ticari kit kullanılarak mikroplaka okuyucuda ölçülmüştür. AChE aktivitelerinin kontrol grubuna göre 96 saat sonra tüm maruziyet gruplarında düştüğü gözlenmiştir. Maruziyet süreleri karşılaştırıldığında 96. saat sonunda enzim aktivitelerinde istatistiksel olarak anlamlı bir değişiklik olmadığı belirlenmiştir. Tüm gruplarda 24 saatin sonunda CYP1A1 seviyelerinde istatistiksel olarak anlamlı bir değişiklik olmamıştır, ancak kontrol grubuna kıyasla 96 saat sonra azalma görülmüştür (p0,05). Dimethoate ve malathion kombinasyonunun toksik yanıtı konsantrasyonlarına bağlı olarak değişebildiği tespit edilmiştir. Sonuç olarak, dimethoate ve malathion karışımlarının, D. polymorpha'da AChE ve CYP1A1 aktivitelerini inhibe ettiği ve bu enzimlerin etkili bir biyobelirteç olarak kullanılabileceği ortaya konmuştur.

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Sıçanlarda Dimetoatla Oluşturulan Hepatotoksisite Üzerine Taflan (Laurocerasus officinalis Roem.) Meyvesinin Koruyucu Etkisi

Cited by 3 publications

References 28 publications

Effect of maturity on the phytonutrient composition of Cape gooseberry seeds (Physalis peruviana L.)

Effect of maturity on the phytonutrient composition of Cape gooseberry seeds (Physalis peruviana L.)

Cherry laurel fruit extract counters dimethoate-induced reproductive impairment and testicular apoptosis

Determination of the Combined Effect of Dimethoate and Malathion Pesticides on Dreissena polymorpha (Pallas, 1771) Using Cytochrome P450 and Acetylcholinesterase

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