Hypothesis: a new basis for sensory-behavioral pretreatments to ameliorate radiation therapy-induced nausea and vomiting?

Blum, Richard

doi:10.1016/0305-7372(88)90004-7

Cited by 4 publications

(4 citation statements)

References 62 publications

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“…A higher proportion of men was found to have been randomized to the no-treatment group than to the oncology-stafftreated group (p < .05). No previous research has found sex of patients to be related to either the development of anticipatory side effects or to treatment effectiveness (Blum, 1988;Burish & Carey, 1986;Burish et al, 1983;Morrow & Dobkin, 1988;Morrow & Morrell, 1982).…”

Section: Resultsmentioning

confidence: 99%

“…Its basic principle is the counterconditioning of an incompatible response (e.g., relaxation) to stimuli or events that elicit maladaptive responses (e.g., nausea and vomiting; Bernstein & Borkevec, 1973). In the case of ANV, it has been shown that these maladaptive side effects can be elicited by stimuli associated with chemotherapy treatment, such as driving to the clinic or seeing the clinic nurse (Andrykowski, Redd, & Hatfield, 1985; Blum, 1988; Morrow & Dobkin, 1988). Recent data have supported the view that similar mechanisms may be involved in the development and expression of PNV (P.…”

Section: Methodsmentioning

confidence: 99%

“…Antiemetic drugs are ineffective in treating this anticipatory nausea and vomiting (ANV; Burish et al, 1983; Carey & Burish, 1988; Morrow, 1989a). The behavioral intervention of systematic desensitization is an effective treatment for ANV (Blum, 1988; Morrow, 1984; Morrow & Morrell, 1982).…”

mentioning

confidence: 99%

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Comparing the effectiveness of behavioral treatment for chemotherapy-induced nausea and vomiting when administered by oncologists, oncology nurses, and clinical psychologists.

Morrow¹,

Asbury²,

Hammon³

et al. 1992

Health Psychology

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Adequate control of side effects during medical treatment of cancer increases patient compliance and quality of life. Antiemetic drugs are not an effective treatment for the one in three cancer patients on chemotherapy who experience anticipatory nausea and vomiting (ANV); the behavioral treatment of systematic desensitization has been found effective for ANV when delivered by clinical psychologists. This study examined the effectiveness of systematic desensitization when delivered by medical personnel versus clinical psychologists. Seventy-two consecutive cancer patients with ANV were randomly assigned to no-treatment control or to systematic desensitization from 5 behaviorally trained clinical psychologists, 6 clinical oncologists, or 10 oncology nurses. The treatment was found effective in reducing anticipatory nausea, anticipatory vomiting, posttreatment nausea, and posttreatment vomiting compared to control patients, with no significant differences in effectiveness found between clinical psychologists and oncology staff. Although medical personnel should not engage patients in psychotherapy or other interventions that cannot be completed successfully, they can treat patients effectively with systematic desensitization and should be encouraged to learn and use this and other behavioral intervention techniques to benefit total patient care.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Comparing the effectiveness of behavioral treatment for chemotherapy-induced nausea and vomiting when administered by oncologists, oncology nurses, and clinical psychologists.

Morrow¹,

Asbury²,

Hammon³

et al. 1992

Health Psychology

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“…Two theories have been proposed, i.e., that substances such as ozone generated by radiation are responsible for the odor [ 1 , 6 ] and that no odor actually exists (phantosmia) [ 2 ]. We recorded the times at which patients reported an odor during a treatment session with a helical TomoTherapy apparatus, and we found that almost all reports occurred in instances when the treatment beam passed through the olfactory epithelium and/or ethmoid sinuses [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Generation of ozone during irradiation using medical linear accelerators: an experimental study

et al. 2022

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Background Some patients have noted a foul odor during radiation therapy sessions, but the cause of the odor remains unknown. Since we suspected that this phenomenon is due to ozone generated by ionizing radiation, this experimental study measured ozone concentrations in the treatment room and in a coiled polyvinyl chloride (PVC) tube placed within the radiation field. Methods We measured ozone concentrations using an ultraviolet absorption method and an ozone monitor. A PVC tube (inner diameter 7 mm, outer diameter 10 mm) was used to mimic the environment of the nasal cavity. The tube (790 cm) was coiled and set between two 4-cm-thick (for X-rays) or 2-cm-thick (for electron beams) water-equivalent solid phantoms. The sampling tube of the ozone monitor was inserted into the PVC tube, and the joint was sealed to prevent environmental air contamination. To measure ozone concentrations in the atmosphere, the sampling tube supplied with the unit was used. A linac was used on a full-sized treatment field (40 cm × 40 cm at a source-to-axis distance of 100 cm). The effect of an electron beam on ozone concentrations was also evaluated with a full-sized treatment field (40 cm × 40 cm at a source-to-surface distance of 100 cm). Results Ozone levels in the treatment room were undetectable before the start of daily treatment but reached 0.008 parts per million (ppm) or more at 1 h after the start of treatment. Concentrations then remained nearly constant at 0.010–0.015 ppm throughout the day. The maximum ozone concentration in the PVC tube was only 0.006 ppm, even when it was irradiated at 2400 monitor units/min. Depending on the X-ray dose rate, the concentration increased to a maximum of 0.010 ppm with oxygen flowing into the other end of the tube at 1.5 L/min. Ozone concentrations in the PVC tube did not differ significantly between X-ray and electron-beam irradiation. Conclusions Only traces of ozone were found in the PVC tube that was used to mimic the nasal passages during radiation, these concentrations were too low for human perception. However, ozone concentrations did reach potentially detectable levels in the treatment room.

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Olfactory sensations produced by high-energy photon irradiation of the olfactory receptor mucosa in humans

Sagar¹,

Thomas²,

Loverock³

et al. 1991

International Journal of Radiation Oncology*Biology*Physics

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Hypothesis: a new basis for sensory-behavioral pretreatments to ameliorate radiation therapy-induced nausea and vomiting?

Cited by 4 publications

References 62 publications

Comparing the effectiveness of behavioral treatment for chemotherapy-induced nausea and vomiting when administered by oncologists, oncology nurses, and clinical psychologists.

Comparing the effectiveness of behavioral treatment for chemotherapy-induced nausea and vomiting when administered by oncologists, oncology nurses, and clinical psychologists.

Generation of ozone during irradiation using medical linear accelerators: an experimental study

Olfactory sensations produced by high-energy photon irradiation of the olfactory receptor mucosa in humans

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