A search for the rare decay K L → π 0 νν was performed. With the data collected in 2015, corresponding to 2.2 × 10 19 protons on target, a single event sensitivity of ð1.30 AE 0.01 stat AE 0.14 syst Þ × 10 −9 was achieved and no candidate events were observed. We set an upper limit of 3.0 × 10 −9 for the branching fraction of K L → π 0 νν at the 90% confidence level (C.L.), which improved the previous limit by almost an order of magnitude. An upper limit for K L → π 0 X 0 was also set as 2.4 × 10 −9 at the 90% C.L., where X 0 is an invisible boson with a mass of 135 MeV=c 2 .

This paper investigates the critical visual tasks of pedestrians, the first step in a review of design guidance for lighting in residential roads. Eye tracking was used to record pedestrians' visual fixations when walking outdoors in daytime and after dark with a concurrent dual task to better understand which fixations were critical. Fixations at critical instances, these being shown by slow reactions to the secondary task, were categorised into one of eight groups. Of these, the path and other people were the most frequent items, with people more likely to be fixated at a far distance and the path at a near distance. After dark the path was more likely to be fixated and other people less likely to be fixated compared with daylight.

During radiotherapy sessions to treat brain tumors or head-and-neck cancers, some patients experience unusual visual and/or olfactory perceptions. This prospective study sought to answer two questions: (i) what proportion of patients experience these unpleasant sensations?, and (ii) which organs are responsible? Eligible patients had brain or near-orbital tumors treated by helical tomotherapy. All were aged 10 years or older, able to communicate, and interviewed by a radiation oncologist at least once weekly during radiation therapy. If they had experienced such sensations, they were encouraged to join the second phase of the study. The patients were asked to indicate, using a button, when a sensation commenced and ended. The recorded data were collated with the treatment log. Thirty-eight consecutive patients were eligible. Twenty-six experienced visual and 13 olfactory sensations. The radiation doses to the organs related to the visual or olfactory sensations did not differ between patients who reported sensations and those who did not. Seventeen patients were enrolled in the second phase of the study. All 14 with visual sensations reported that the sensations occurred when the X-rays passed at eye level. Olfactory sensations were reported by eight out of nine patients when the X-rays passed through the olfactory epithelium and/or ethmoid sinus level. In conclusion, 68% of patients experienced visual sensations caused by X-rays passing through the level of the eyes, and 34% complained of olfactory sensations. With the exception of one patient, olfactory sensations occurred when the X-rays passed through the levels of the olfactory epithelium and/or ethmoid sinus.

Excellent thermal and operational stabilities of thermophilic enzymes can greatly increase the applicability of biocatalysis in various industrial fields. However, thermophilic enzymes are generally incompatible with thermo-labile substrates, products, and cofactors, since they show the maximal activities at high temperatures. Despite their pivotal roles in a wide range of enzymatic redox reactions, NAD(P)(+) and NAD(P)H exhibit relatively low stabilities at high temperatures, tending to be a major obstacle in the long-term operation of biocatalytic chemical manufacturing with thermophilic enzymes. In this study, we constructed an in vitro artificial metabolic pathway for the salvage synthesis of NAD(+) from its degradation products by the combination of eight thermophilic enzymes. The enzymes were heterologously produced in recombinant Escherichia coli and the heat-treated crude extracts of the recombinant cells were directly used as enzyme solutions. When incubated with experimentally optimized concentrations of the enzymes at 60°C, the NAD(+) concentration could be kept almost constant for 15h.

A simulation method to determine adaptation luminance is proposed for implementation of the CIE mesopic photometry system. The simulation takes four factors into account: luminance distribution, eye movement of observers, surrounding luminance effect and area of measurement. Each factor is modelled as a two-dimensional geometrical function. The method determines an adaptation luminance for the area of measurement through four calculation steps. The simulation method was applied to examples of luminance distributions of outdoor lit scenes and the results were compared with possible simple predictors of adaptation luminance. The comparisons suggest that the average luminance of the area of measurement can be considered as a good approximation in most of the cases. Exceptions are scenes for pedestrians in which there are many bright sources surrounding the area of measurement.

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Background Some patients have noted a foul odor during radiation therapy sessions, but the cause of the odor remains unknown. Since we suspected that this phenomenon is due to ozone generated by ionizing radiation, this experimental study measured ozone concentrations in the treatment room and in a coiled polyvinyl chloride (PVC) tube placed within the radiation field. Methods We measured ozone concentrations using an ultraviolet absorption method and an ozone monitor. A PVC tube (inner diameter 7 mm, outer diameter 10 mm) was used to mimic the environment of the nasal cavity. The tube (790 cm) was coiled and set between two 4-cm-thick (for X-rays) or 2-cm-thick (for electron beams) water-equivalent solid phantoms. The sampling tube of the ozone monitor was inserted into the PVC tube, and the joint was sealed to prevent environmental air contamination. To measure ozone concentrations in the atmosphere, the sampling tube supplied with the unit was used. A linac was used on a full-sized treatment field (40 cm × 40 cm at a source-to-axis distance of 100 cm). The effect of an electron beam on ozone concentrations was also evaluated with a full-sized treatment field (40 cm × 40 cm at a source-to-surface distance of 100 cm). Results Ozone levels in the treatment room were undetectable before the start of daily treatment but reached 0.008 parts per million (ppm) or more at 1 h after the start of treatment. Concentrations then remained nearly constant at 0.010–0.015 ppm throughout the day. The maximum ozone concentration in the PVC tube was only 0.006 ppm, even when it was irradiated at 2400 monitor units/min. Depending on the X-ray dose rate, the concentration increased to a maximum of 0.010 ppm with oxygen flowing into the other end of the tube at 1.5 L/min. Ozone concentrations in the PVC tube did not differ significantly between X-ray and electron-beam irradiation. Conclusions Only traces of ozone were found in the PVC tube that was used to mimic the nasal passages during radiation, these concentrations were too low for human perception. However, ozone concentrations did reach potentially detectable levels in the treatment room.

An experiment was carried out to investigate spatial brightness at photopic levels under lighting of different spectral power distributions. One aim was to replicate the experiment reported in 1990 by Berman et al. demonstrating that light with a higher scotopic / photopic (S/P) ratio would be perceived as brighter. In addition, a third SPD was included to investigate gamut area and two additional procedures were employed to provide concurrent validity of the findings. It was concluded that while lighting of higher S/P ratio was brighter, the S/P ratio alone was insufficient to predict spatial brightness. A metric for the chromatic contribution is also needed, this being provided by gamut area in the current work.