Olfactory sensations produced by high-energy photon irradiation of the olfactory receptor mucosa in humans

Sagar, Stephen M.; Thomas, Robert J.; Loverock, L.T.; Spittle, Margaret F.

doi:10.1016/0360-3016(91)90021-u

Cited by 32 publications

(44 citation statements)

References 19 publications

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“…Furthermore, other critically enriched genes included the olfactory receptors (COL4A5, COL4A4, COL4A3 and COL9A3) and also GPCRs, which suggested that olfactory factors might trigger radiation response that promoted the downstream effects. Previous research also indicated that radiochemical formation of ozone and free radicals might stimulate olfactory receptors in radiation processes [ 64 , 65 ].…”

Section: Discussionmentioning

confidence: 99%

Gene Profiling Characteristics of Radioadaptive Response in AG01522 Normal Human Fibroblasts

et al. 2015

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Radioadaptive response (RAR) in mammalian cells refers to the phenomenon where a low-dose ionizing irradiation alters the gene expression profiles, and protects the cells from the detrimental effects of a subsequent high dose exposure. Despite the completion of numerous experimental studies on RAR, the underlying mechanism has remained unclear. In this study, we aimed to have a comprehensive investigation on the RAR induced in the AG01522 human fibroblasts first exposed to 5 cGy (priming dose) and then followed by 2 Gy (challenge dose) of X-ray through comparisons to those cells that had only received a single 2 Gy dose. We studied how the priming dose affected the expression of gene transcripts, and to identify transcripts or pathways that were associated with the reduced chromosomal damages (in terms of the number of micronuclei) after application of the challenging dose. Through the mRNA and microRNA microarray analyses, the transcriptome alteration in AG01522 cells was examined, and the significantly altered genes were identified for different irradiation procedures using bioinformatics approaches. We observed that a low-dose X-ray exposure produced an alert, triggering and altering cellular responses to defend against subsequent high dose-induced damages, and accelerating the cell repair process. Moreover, the p53 signaling pathway was found to play critial roles in regulating DNA damage responses at the early stage after application of the challenging dose, particularly in the RAR group. Furthermore, microRNA analyses also revealed that cell communication and intercellular signaling transduction played important roles after low-dose irradiation. We conclude that RAR benefits from the alarm mechanisms triggered by a low-dose priming radation dose.

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Section: Discussionmentioning

confidence: 99%

Gene Profiling Characteristics of Radioadaptive Response in AG01522 Normal Human Fibroblasts

et al. 2015

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“…Dysosmia can be induced by head trauma, 3,10 postviral upper respiratory infection (URI), 11 toxic exposure, 12 psychiatric problems, 13,14 medication, 15 radiotherapy, 16,17 trimethylaminuria, 18,19 and tumors of the frontal lobe or of the olfactory bulb, tract, or groove 20 . However, dysosmia secondary to nasal/sinus inflammatory disease has been referred to very sparsely in the literature 4,21 …”

Section: Introductionmentioning

confidence: 99%

Prevalence and Assessment of Qualitative Olfactory Dysfunction in Different Age Groups

et al. 1996

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The prevalence of parosmia and phantosmia among 363 chemosensory and nasal/sinus patients was studied, as was the accuracy with which our clinical questionnaire could assess these dysfunctions. We then investigated whether patients with parosmia or phantosmia, matched for odor intensity, perform poorer on odor identification than do patients with no dysosmia. More than 40% of the study group evidenced either parosmia (18.7%) and/or phantosmia (25.6%), a finding that suggests that more attention should be paid by the medical practitioner in addressing qualitative olfactory dysfunction. Furthermore, it appears that assessment of these dysfunctions may aid in differential diagnosis, and that questionnaires can be used with reasonable validity irrespective of the patient's age. Finally, the results imply that parosmia may be reflected in a discrepancy between odor identification and detection.

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“…Additionally, the KEGG pathway analysis showed that not only cancer pathways but also olfactory and taste transduction were significantly changed in HPC tumors after they were treated by 188 Re-liposome. Although no clinical evidence showing that patients treated with 188 Re-liposome will lose olfactory and gustatory sensation, olfactory sensory dysfunction and gustatory impairment often occur after patients are treated with radiotherapy in the head and neck area [82,[86][87][88][89]. To the best of our knowledge, this is the first study uncovering the therapeutic mechanisms of 188 Re-liposome by an investigation of the pan-expression of microRNA.…”

Section: Discussionmentioning

confidence: 91%

Involvement of Differentially Expressed microRNAs in the PEGylated Liposome Encapsulated 188Rhenium-Mediated Suppression of Orthotopic Hypopharyngeal Tumor

Lin¹,

Wan

Ma³

et al. 2020

Molecules

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Hypopharyngeal cancer (HPC) accounts for the lowest survival rate among all types of head and neck cancers (HNSCC). However, the therapeutic approach for HPC still needs to be investigated. In this study, a theranostic 188Re-liposome was prepared to treat orthotopic HPC tumors and analyze the deregulated microRNA expressive profiles. The therapeutic efficacy of 188Re-liposome on HPC tumors was evaluated using bioluminescent imaging followed by next generation sequencing (NGS) analysis, in order to address the deregulated microRNAs and associated signaling pathways. The differentially expressed microRNAs were also confirmed using clinical HNSCC samples and clinical information from The Cancer Genome Atlas (TCGA) database. Repeated doses of 188Re-liposome were administrated to tumor-bearing mice, and the tumor growth was apparently suppressed after treatment. For NGS analysis, 13 and 9 microRNAs were respectively up-regulated and down-regulated when the cutoffs of fold change were set to 5. Additionally, miR-206-3p and miR-142-5p represented the highest fold of up-regulation and down-regulation by 188Re-liposome, respectively. According to Differentially Expressed MiRNAs in human Cancers (dbDEMC) analysis, most of 188Re-liposome up-regulated microRNAs were categorized as tumor suppressors, while down-regulated microRNAs were oncogenic. The KEGG pathway analysis showed that cancer-related pathways and olfactory and taste transduction accounted for the top pathways affected by 188Re-liposome. 188Re-liposome down-regulated microRNAs, including miR-143, miR-6723, miR-944, and miR-136 were associated with lower survival rates at a high expressive level. 188Re-liposome could suppress the HPC tumors in vivo, and the therapeutic efficacy was associated with the deregulation of microRNAs that could be considered as a prognostic factor.

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Olfactory sensations produced by high-energy photon irradiation of the olfactory receptor mucosa in humans

Cited by 32 publications

References 19 publications

Gene Profiling Characteristics of Radioadaptive Response in AG01522 Normal Human Fibroblasts

Gene Profiling Characteristics of Radioadaptive Response in AG01522 Normal Human Fibroblasts

Prevalence and Assessment of Qualitative Olfactory Dysfunction in Different Age Groups

Involvement of Differentially Expressed microRNAs in the PEGylated Liposome Encapsulated 188Rhenium-Mediated Suppression of Orthotopic Hypopharyngeal Tumor

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