Hypoglycemic effects of Berberis aristata and Tamarindus indica extracts in vitro

Bhutkar, Mangesh A.; Bhinge, Somnath D.; Randive, Dheeraj S.; Wadkar, Ganesh H.

doi:10.1016/j.bfopcu.2016.09.001

Cited by 29 publications

(24 citation statements)

References 19 publications

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“…The assay was carried out according to Bhutkar et al (2017). To prepare the suspension, commercial yeast was washed three times with distilled water and then centrifuged (3000 x g, 5 min) until the supernatant was clear.…”

Section: Effect Of Pee On Glucose Intake By Saccharomyces Cerevisiae mentioning

confidence: 99%

Integral use of Argentinean Solanum betaceum red fruits as functional food ingredient to prevent metabolic syndrome: effect of in vitro simulated gastroduodenal digestion

Orqueda

Torres

Zampini

et al. 2020

Heliyon

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A B S T R A C TThe "red chilto" (Solanum betaceum Cav) is a native fruit from the Yungas forest of Argentina. Red chilto is a neglected and underutilized native species (NUS). The objective of this work was to evaluate the potentiality of pulp, seed and skin from "red chilto" as a functional food ingredient to add value to a native resource of Argentine Yungas to promote sustainable integral use of it. The powders have low carbohydrate and sodium content and are a source of vitamin C, phenolic acids (rosmarinic acid and caffeoylquinic acid), anthocyanins, condensed tannins, carotenoids, potassium, and fiber. The phenolics of chilto powders showed, before and after simulated gastroduodenal digestion, antioxidant activity (ABTS þ ; H 2 O 2 ; O 2 ; HO ) and were able to inhibit enzymes related to metabolic syndrome, such as α-glucosidase, α-amylase and lipase. Chilto powder showed hypoglycemic effect by increasing glucose adsorption, decreasing glucose diffusion rate and by promoting glucose transport across the cell membrane. These results suggest the potential of Argentinean "red chilto" fruits as functional food ingredients or dietary supplements to prevent metabolic syndrome principally by its antioxidant, hypoglycemic and hypolipemic effects.

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Section: Effect Of Pee On Glucose Intake By Saccharomyces Cerevisiae mentioning

confidence: 99%

Integral use of Argentinean Solanum betaceum red fruits as functional food ingredient to prevent metabolic syndrome: effect of in vitro simulated gastroduodenal digestion

Orqueda

Torres

Zampini

et al. 2020

Heliyon

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“…Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia and disturbances of carbohydrate, protein and fat metabolisms, secondary to an absolute or relative lack of the hormone insulin (Bhutkar, Bhise, 2012;Bhutkar et al, 2016). There is a global increase in the prevalence of diabetes mellitus predominantly, related to lifestyles and the resulting surge in obesity (King et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

In vitro hypoglycemic effects of unripe and ripe fruits of Musa sapientum

Bhinge¹,

Bhutkar²,

Randive³

et al. 2018

Braz. J. Pharm. Sci.

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The present study was undertaken to verify the hypoglycemic potential of unripe and ripe fruit extracts of Musa sapientum by using various in-vitro techniques, namely glucose adsorption capacity, glucose diffusion, amylolysis kinetics and glucose transport across the yeast cells. The results revealed that the unripe and ripe fruit extracts of Musa sapientum adsorbed glucose and the adsorption of glucose increased remarkably with an increase in glucose concentration. There were no significant (p≤0.05) differences between their adsorption capacities. In the amylolysis kinetic experimental model the rate of glucose diffusion was found to be increased with time from 30 to 180 min and both extracts exhibited significant inhibitory effects on the movement of glucose into external solution across the dialysis membrane as compared to control. The plant extracts also promoted glucose uptake by the yeast cells and enhancement of glucose uptake was dependent on both the sample and glucose concentration. The hypoglycemic effect exhibited by the extracts was observed to be mediated by inhibiting α-amylase, inhibiting glucose diffusion by adsorbing glucose and by increasing glucose transport across the cell membranes as revealed by an in-vitro model of yeast cells.

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“…This study on the transport of nonmetabolizable sugar and glycosides suggested that glucose transport across the yeast cell membrane and mediated by facilitated carriers are specific carriers that transport solutes down the concentration gradient. This means that effective transport is only attained if there is the removal of intracellular glucose . S. saman leaf extract shows an excellent antidiabetic activity.…”

Section: Discussionmentioning

confidence: 99%

Exploring the antidiabetic and anti‐obesity properties of Samanea saman through in vitro and in vivo approaches

Vinodhini

Rajeswari

2018

J of Cellular Biochemistry

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In recent years, diabetes and obesity have become a major problem in global health care because of changes in lifestyle, food habits, and age‐related metabolic disorders. Diabetes mellitus is one of the most common diseases, affecting millions of people worldwide. Currently, herbal drugs are used to control obesity and diabetes. The present study investigates the anti‐obesity, antidiabetic, and antioxidant activities of Samanea saman leaf extract. A methanolic extract of S. saman leaves was prepared by a maceration method. The S. saman leaf extract was studied for its inhibitory effect on glucose utilization using specific in vitro procedures to analyze its antioxidant, anti‐obesity, and antidiabetic activities via different assays, such as α‐amylase and α‐glucosidase inhibition assay, glucose uptake by yeast cells, nonenzymatic glycosylation assay followed by glucose diffusion assay. The outcome of the study showed that the methanolic extract strongly inhibited the pancreatic lipase, α‐amylase, and glucosidase activities, compared with the standard drug. The results showed that the extract possessed considerable antioxidant and antidiabetic activities, and further studies are needed to confirm the results using an in vivo model. Thus, it is proposed that S. saman can be used as a therapeutic agent.

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Hypoglycemic effects of Berberis aristata and Tamarindus indica extracts in vitro

Cited by 29 publications

References 19 publications

Integral use of Argentinean Solanum betaceum red fruits as functional food ingredient to prevent metabolic syndrome: effect of in vitro simulated gastroduodenal digestion

Integral use of Argentinean Solanum betaceum red fruits as functional food ingredient to prevent metabolic syndrome: effect of in vitro simulated gastroduodenal digestion

In vitro hypoglycemic effects of unripe and ripe fruits of Musa sapientum

Exploring the antidiabetic and anti‐obesity properties of Samanea saman through in vitro and in vivo approaches

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