Exploring the antidiabetic and anti‐obesity properties of Samanea saman through in vitro and in vivo approaches

Abstract

In recent years, diabetes and obesity have become a major problem in global health care because of changes in lifestyle, food habits, and age‐related metabolic disorders. Diabetes mellitus is one of the most common diseases, affecting millions of people worldwide. Currently, herbal drugs are used to control obesity and diabetes. The present study investigates the anti‐obesity, antidiabetic, and antioxidant activities of Samanea saman leaf extract. A methanolic extract of S. saman leaves was prepared by a maceration method. The S. saman leaf extract was studied for its inhibitory effect on glucose utilization using specific in vitro procedures to analyze its antioxidant, anti‐obesity, and antidiabetic activities via different assays, such as α‐amylase and α‐glucosidase inhibition assay, glucose uptake by yeast cells, nonenzymatic glycosylation assay followed by glucose diffusion assay. The outcome of the study showed that the methanolic extract strongly inhibited the pancreatic lipase, α‐amylase, and glucosidase activities, compared with the standard drug. The results showed that the extract possessed considerable antioxidant and antidiabetic activities, and further studies are needed to confirm the results using an in vivo model. Thus, it is proposed that S. saman can be used as a therapeutic agent.

In Vitro Hypoglycemic and Anti-Inflammatory Potential and Toxicity of Powders from Pulp and by-Products of Ziziphus mistol from Argentina

“…The study of glucose transport across the yeast cell membrane has been considered a meaningful in vitro technique that is effective for the screening of natural compounds with hypoglycemic activity [ 24 ]. Since glucose transport across the yeast cell membrane occurs via facilitated diffusion and is promoted by specific membrane carriers, i.e., those that transport glucose down a concentration gradient, an increase in the glucose uptake implies an improvement in the use of intracellular glucose [ 25 ]. Additionally, the polyphenols of mistol fruits could affect the glucose transporters of the yeast membrane.…”

Rose Petal Extract Ameliorates Obesity in High Fat Diet-Induced Obese Mice

“…The prevalence of obesity has been constantly increasing globally over the past few decades. Obesity is a complex chronic condition; it is characterized by excess body fat accumulation, which can lead to negative health outcomes such as cardiovascular disease, diabetes, and certain types of cancer ( Vinodhini and Rajeswari, 2019 ; Karadogan et al, 2022 ). Depending on the severity of the condition, the treatment for obesity involves a multi-faceted approach that includes lifestyle modifications, bariatric surgery, and pharmacotherapy.…”

Synthesis of 2-(4-hydroxyphenyl)ethyl 3,4,5-Trihydroxybenzoate and Its Inhibitory Effect on Sucrase and Maltase

“…The residue was purified by silica gel column chromatography to give 7 as a white solid (9.3 g, yield: 54%). 1 H-NMR (600 MHz, CDCl 3 ): δ 2.98 (2 H, t, J = 6.9, 7.2 Hz, H B -7), 4.44 (2 H, t, J = 6.6, 6.9 Hz, H B -8), 5.10 (2 H, s, H A -7"), 5.10 (4 H, s, H A -7 , 7 ), 6.92 (2 H, d, J = 8.4 Hz, H B -3, 5), 7.17 ( -7 ). TLC R f = 0.7 (EtOAc:Hexanes = 1:1) ppm; ESIMS m/z 289.13 [M + H] − .…”

“…Changes in food habits and population aging have led to an expansion in the occurrence of diabetes [1]. Defects in the regulation of insulin secretion manifest as endocrine and metabolic dysregulation in the form of chronic hyperglycemia, dyslipidemia, and disorders of protein metabolism [2].…”