Hypoglycemic and hypolipidemic effects of aqueous extract of Arachis hypogaea in normal and Alloxan-induced diabetic rats

Bilbis, L. S.; Shehu, R.A.; Abubakar, M. G.

doi:10.1078/09447110260573191

Cited by 31 publications

(25 citation statements)

References 11 publications

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“…Moreover, peanut hulls are also known for its antidiabetic properties traditionally. This is further supported by a study concerning Arachis hypogaea, which indicated that treatment of the extract to normal and alloxan-induced diabetic rats could decrease the fasting blood glucose as well as serum triglyceride, total cholesterol, HDL-cholesterol, and LDL-cholesterol [1]. The compounds with antidiabetic activity were stigmast-5-en-3-ol, linoleic acid, and oleic acid.…”

Section: Introductionsupporting

confidence: 53%

Metabolite Variation of Peanut Hulls (Arachis hypogaea L.) from Three Locations of Lombok Island on the Basis of GC-MS Analysis

Hadi

Asnawati

Mariana

et al. 2017

J. Pure App. Chem. Res.

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This article is a part of studies to investigate the potential of natural products from Lombok Island for antidiabetic agents. This study was directed to learn the metabolite variations of peanut hulls collected from three different locations in Lombok Island. The hull samples were extracted in methanol, followed by partition process into three fractions using three solvents with varied polarities (dichloromethane, hexane and acetone). The fractions were then separated and identified for their chemical composition by using GC-MS instrument. Metabolite variations of three extracts showed that the antidiabetic compounds stigmast-5-en-3-ol and oleic acid were found in all three locations with different percentages of abundance. Another antidiabetic compound, linoleic acid, was only identified in peanut hulls from the village of Pringga Jurang (PJ). Besides the antidiabetic compounds, there were other major compounds with known biological activities discussed to find other uses of the hulls.

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Section: Introductionsupporting

confidence: 53%

Metabolite Variation of Peanut Hulls (Arachis hypogaea L.) from Three Locations of Lombok Island on the Basis of GC-MS Analysis

Hadi

Asnawati

Mariana

et al. 2017

J. Pure App. Chem. Res.

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“…We respect of the bioactivity of this plant product, the peanut seed contains a mixture of triacylglycerols, which inhibits pancreatic lipase (Hochstrasser et al, 1972), and the hypoglycemic and hypolipidemic effects on rats of aqueous extract of peanut seeds had also been reported (Bilbis et al, 2002). Luteolin, a flavonoid present in the ethanolic extract of the nutshells, was also reported as a weak inhibitor of lipase (Yamamoto et al, 2000).…”

Section: Introductionmentioning

confidence: 95%

Effects of Arachis hypogaea nutshell extract on lipid metabolic enzymes and obesity parameters

et al. 2006

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“…The hypoglycemic, toxicity and hypolipidemic effect of the aqueous leaf extract of A.chevalieri has been reported extensively by Saidu et al (2007aSaidu et al ( , b, c, 2009Saidu et al ( , 2010. Bilbis et al (2002) also reported the hypoglycemic and hypolipidemic effect of A. hypogea seed in alloxan induced diabetic rats. V. amygdalina, C. procera, and M. indica aqueous extracts were also reported to possess significant hypoglycaemic effects (Etuk and Mohammed, 2009).…”

Section: Discussionmentioning

confidence: 81%

-Glucosidase inhibitory potential of selected anti-diabetic plants used in North-Western Nigeria

Onu¹,

rew²,

Saidu³

et al. 2013

J. Med. Plants Res.

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α-Glucosidase inhibitory potential of selected anti-diabetic plants has been studied. The study evaluated α-glucosidase inhibition using α-glucosidase from Saccharomyces cerevisiae and pnitrophenyl α-D-glucopyranoside as substrate. The result showed that the extract of Albizzia chevalieri leaf, Khaya senegalensis stem bark, Zizypus spina-christi stem bark, Arachis hypogea seed varieties and Mangifera indica leaf had significant (P < 0.05) α-glucosidase inhibitory effect in a concentration dependant manner as compared to acarbose. Cardiac glycosides, alkaloids, saponins, flavonoids and tannins were identified in the extracts. The study concludes that the plant extract contain bioactive compound that may be source(s) of lead compounds with α-glucosidase inhibitory potentials and may explain their hypoglycaemic effects.

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Hypoglycemic and hypolipidemic effects of aqueous extract of Arachis hypogaea in normal and Alloxan-induced diabetic rats

Cited by 31 publications

References 11 publications

Metabolite Variation of Peanut Hulls (Arachis hypogaea L.) from Three Locations of Lombok Island on the Basis of GC-MS Analysis

Metabolite Variation of Peanut Hulls (Arachis hypogaea L.) from Three Locations of Lombok Island on the Basis of GC-MS Analysis

Effects of Arachis hypogaea nutshell extract on lipid metabolic enzymes and obesity parameters

-Glucosidase inhibitory potential of selected anti-diabetic plants used in North-Western Nigeria

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