-Glucosidase inhibitory potential of selected anti-diabetic plants used in North-Western Nigeria

Abstract

α-Glucosidase inhibitory potential of selected anti-diabetic plants has been studied. The study evaluated α-glucosidase inhibition using α-glucosidase from Saccharomyces cerevisiae and pnitrophenyl α-D-glucopyranoside as substrate. The result showed that the extract of Albizzia chevalieri leaf, Khaya senegalensis stem bark, Zizypus spina-christi stem bark, Arachis hypogea seed varieties and Mangifera indica leaf had significant (P < 0.05) α-glucosidase inhibitory effect in a concentration dependant manner as compared to acarbose. Cardiac glycosides, alkaloids, saponins, flavonoids and tannins were identified in the extracts. The study concludes that the plant extract contain bioactive compound that may be source(s) of lead compounds with α-glucosidase inhibitory potentials and may explain their hypoglycaemic effects.

Synthesis, Spectroscopic Analysis and Antidiabetic Properties of Copper (II) Complex of Mangifera indica Leaf Crude Extract

“…The leaves of Mangifera indica Linn. commonly called mango have been applied for the treatment of fever, diarrhea, fainting, abnormality of lymph nodes, diabetes, and many ailments (Aderibigbe et al, 2001;Dineshkumar et al, 2010;Andrew et al, 2013;Garrido-Suarez et al, 2014;Ganogpichayagrai et al, 2017). The bioactivities of the leaf are attributed to the presence of secondary metabolites which include flavonoids, tannins, alkaloids, terpenoids, anthraquinones, saponins, cardiac glycosides, and steroids.…”