Hypobaric hypoxia-induced dendritic atrophy of hippocampal neurons is associated with cognitive impairment in adult rats

Titus, David J.; Rao, B.S. Shankaranarayana; Harsha, H.N.; Ramkumar, K.M.; Srikumar, B.N.; Singh, Shashi Bala; Chattarji, Sumantra; Raju, T.R.

doi:10.1016/j.neuroscience.2006.11.037

Cited by 133 publications

(98 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Consistent with previous studies of IH (44,53) and patients with OSA (20, 37), we observed impaired learning and memory. The effects of IH and sleep deprivation were previously determined to have distinct effects on the central nervous system, although both have separately been associated with impaired memory function, specifically in spatial learning tasks (25)(26)(27).…”

Section: Discussionsupporting

confidence: 93%

“…Brief IH stimulates neurogenesis and reduces depressive-like behaviors (34,54). However, negative outcomes, such as impaired cognitive functions, increased inflammation, and oxidative stress are more common following chronic IH (19,32,44). Tumor necrosis factor-␣ (TNF-␣) is one inflammatory gene that often increases in expression during IH; increased TNF-␣ gene expression occurs at the onset of IH treatment and begins to decrease with prolonged exposure (24).…”

mentioning

confidence: 99%

“…Additionally, vascular endothelial growth factor (VEGF) gene expression typically increases with exposure to IH, an observation that has been suggested to be the basis of both negative and positive outcomes observed in IH models (4,49). Similarly, exposure to hypobaric hypoxia, mimicking high altitudes, Յ14 days induces dendritic atrophy in the hippocampus and cortex, whereas structural recovery occurs after 21 days of hypobaric hypoxia with a corresponding improvement in spatial memory (21,44). Thus, hypoxia has markedly different effects depending on duration.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Dim light at night interacts with intermittent hypoxia to alter cognitive and affective responses

Aubrecht

Weil

Magalang

et al. 2013

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Aubrecht TG, Weil ZM, Magalang UJ, Nelson RJ. Dim light at night interacts with intermittent hypoxia to alter cognitive and affective responses. Am J Physiol Regul Integr Comp Physiol 305: R78 -R86, 2013. First published May 8, 2013 doi:10.1152/ajpregu.00100.2013 and dim light at night (dLAN) have both been independently associated with alterations in mood and cognition. We aimed to determine whether dLAN would interact with intermittent hypoxia (IH), a condition characteristic of OSA, to alter the behavioral, cognitive, and affective responses. Adult male mice were housed in either standard lighting conditions (14:10-h light-dark cycle; 150 lux:0 lux) or dLAN (150 lux:5 lux). Mice were then exposed to IH (15 cycles/h, 8 h/day, FIO 2 nadir of 5%) for 3 wk, then tested in assays of affective and cognitive responses; brains were collected for dendritic morphology and PCR analysis. Exposure to dLAN and IH increased anxiety-like behaviors, as assessed in the open field, elevated plus maze, and the light/dark box. dLAN and IH increased depressive-like behaviors in the forced swim test. IH impaired learning and memory performance in the passive avoidance task; however, no differences were observed in spatial working memory, as assessed by y-maze or object recognition. IH combined with dLAN decreased cell body area in the CA1 and CA3 regions of the hippocampus. Overall, IH decreased apical spine density in the CA3, whereas dLAN decreased spine density in the CA1 of the hippocampus. TNF-␣ gene expression was not altered by IH or lighting condition, whereas VEGF expression was increased by dLAN. The combination of IH and dLAN provokes negative effects on hippocampal dendritic morphology, affect, and cognition, suggesting that limiting nighttime exposure to light in combination with other established treatments may be of benefit to patients with OSA.

show abstract

Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Dim light at night interacts with intermittent hypoxia to alter cognitive and affective responses

Aubrecht

Weil

Magalang

et al. 2013

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

“…Exposure to more days result in significant reduction in branching points, intersections and dendric length in most of the segments, significantly elevated levels of calcium and protein synthesis may lead to delayed neuronal death in CA1 region after hypoxia. The CA3 cells have higher level of metabolic activity than the CA1 cells and this may make them more vulnerable to hypoxia (Titus et al, 2007) Glutamate is a major excitatory neurotransmitter in brain. Down regulation of glutamate transporter expression and uptake, activity was observed during hypoxia.…”

Section: Discussionmentioning

confidence: 99%

Cerebroprotective effect of Glycyrrhiza glabra Linn. root extract

Muralidharan¹,

Balamurugan²,

Babu³

2008

Bangladesh J Pharmacol

View full text Add to dashboard Cite

“…Working memory and reference memory are the two variables that report the physiological status of the brain. 29 Thus, LPS-treated rats with the EEPM (100, 200 and 400 mg/kg) exhibited an improvement of working memory as compared to LPS alone-treated rats in radial arm-maze task. The choice reaction time task represents the first step of cognition and memory and is related to attention and immediate memory retention ability.…”

Section: Pharmacological Studiesmentioning

confidence: 82%

Neuroprotective Effect of Pedalium murex Linn. Leaf against Lipopolysaccharide Induced Behavioural Disorders in Rats

Swaminathan¹,

Sundaram²,

Annapandian³

et al. 2017

View full text Add to dashboard Cite

1Endotoxic shock can be elicited by a systemic injection of LPS which induces the production and release of several cytokines.2 In response to these cytokines, several reactive oxygen species (ROS) are produced from cells such as neutrophils and other phagocytic cells, creating a status of oxidative stress.3 Thus, this type of stress may hypothetically support the assumption that LPSinduced cell injury would be retarded by modifying free radical metabolism with the aid of potent antioxidant pre-treatment from nature. Certain reports have claimed that a few herbal extracts can act on the central nervous system, thereby enhancing the faculties of learning and memory. 4 The . At the end of the study, rats were sacrificed, brain hippocampal region was removed and biochemical parameters were measured. Results: In WMT swimming length (cm) was increased in LPS-treated rats when compared to control animals, the swimming length (EEPM; 400 mg/kg) was found to be significant; in RAM, different doses of EEPM at 100, 200 and 400 mg/kg decreased the number of errors in entry 4.00±0.36, 4.16±0.16and 3.33±2.79 respectively when compared with control animals (2.66± 0.21). EEPM at 400 mg/kg showed significant activity, in CRT apparatus increased incorrect lever pressing was observed in LPS-treated rats when compared to control animals. Incorrect lever pressing was minimized by EEPM at 400 mg/kg (43.5±2.40). Conclusions: Our results showed that EEPM is a hopeful aspirant for hindrance of infection and inflammation induced brain damage by LPS.

show abstract

Hypobaric hypoxia-induced dendritic atrophy of hippocampal neurons is associated with cognitive impairment in adult rats

Cited by 133 publications

References 65 publications

Dim light at night interacts with intermittent hypoxia to alter cognitive and affective responses

Dim light at night interacts with intermittent hypoxia to alter cognitive and affective responses

Cerebroprotective effect of Glycyrrhiza glabra Linn. root extract

Neuroprotective Effect of Pedalium murex Linn. Leaf against Lipopolysaccharide Induced Behavioural Disorders in Rats

Contact Info

Product

Resources

About