Cerebroprotective effect of Glycyrrhiza glabra Linn. root extract

Muralidharan, P.; Balamurugan, G.; Babu, V L Ashoka

doi:10.3329/bjp.v4i1.1052

Cited by 24 publications

(24 citation statements)

References 19 publications

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“…Glabridin significantly decreases the level of MDA and it elevates the level superoxide dismutase and reduced glutathione in the brain [58]. A study indicated that administration of G. glabra restored the decreased levels of brain enzymes such as glutamate and dopamine and decreased AChE activity [59].…”

Section: Glycyrrhiza Glabramentioning

confidence: 98%

Herbal Medicines as Neuroprotective Agent: A Mechanistic Approach

Roy

Awasthi

2017

Int J Pharm Pharm Sci

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Neurodegeneration refers to a condition of neuronal death occurring as a result of progressive disease of long-term and is becoming a major health problem in the 21st century. Neurons degenerated are not replaced resulting in a cognitive loss, many neurodegenerative disorders, such as schizophrenia, depression, Alzheimer's disease (AD), dementia, cerebrovascular impairment, seizure disorders, head injury, parkinsonism. The common pathology of neurodegeneration includes deposition of misfolded proteins such as amyloid-β (Aβ) in Alzheimer's disease, α-synuclein in Parkinson's disease (PD), transactive response DNA-binding protein 43 (TDP-43) in dementia. Neuroprotection refers to the strategies and possible mechanisms that are able to protect the central nervous system (CNS) against neuronal injury and neurodegenerative disorders. The past decade has witnessed an intense interest in herbal plants having long-term health-promoting or medicinal qualities. Comprehensive research and discovery have demonstrated that natural products, medicinal herbs, plant extracts, and their metabolites, have great potential as the neuroprotective agent. Although the precise mechanisms of action of herbal drugs have yet to be determined, some of them have been shown to prevent formation of betaamyloid plaques, promote nerve growth, some inhibit acetylcholinesterase (AChE) enzyme and malondialdehyde (MDA) formation in brain while other exhibits antioxidant activity by increasing the level of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx). Thus the herbal plants can be a valuable source of the drug against neurodegenerative disorders which will require high-throughput screening. This review will highlight the role of herbal plants and their phytoconstituents against neurodegenerative diseases and other related disorders, focusing on their mechanism of action and therapeutic potential.

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Section: Glycyrrhiza Glabramentioning

confidence: 98%

Herbal Medicines as Neuroprotective Agent: A Mechanistic Approach

Roy

Awasthi

2017

Int J Pharm Pharm Sci

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“…Lipid peroxidation was also restored by extract of Glycyrrhiza glabra. Thus anti-oxidant and neurotransmitter modulating activity explain the potential cerebroprotective effect of Glycyrrhiza glabra in hypoxic rat [36]. Scientists also investigated the antinociceptive activity of aqueous and ethanolic extracts of Glycyrrhiza glabra by using different pain models like acetic acid induced abdominal constrictions, formalin induced hyperalgesia and tail flick method in Swiss albino mice.…”

Section: Fementioning

confidence: 99%

Pharmacological Perspective of Glycyrrhiza glabraLinn.: a Mini-Review

Thakur¹,

Raj²

2017

JAPLR

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The Glycyrrhiza genus contains more than 30 species and widely distributed all over the world [7]. Glycyrrhiza genus plants are wide spread in Mediterranean, Southern and Central Russia and Asia, being minor to Iran. Many species are now grown throughout Europe, Syria, Asia, UK, USA, Italy, France, Germany, AbstractGlycyrrhiza glabra Linn. (Family: Fabaceae) is a traditional medicinal plant used in various ancient medicine systems and documented across the globe for its ethanopharmacological value to cure varieties of ailments. Glycyrrhizin is the major active constituent obtained from liquorice roots, one of the most widely used in herbal preparations for the treatment and management of chronic diseases. The present mini-review is focused mainly on major secondary metabolites, ethnopharmacology and potential medicinal uses of Glycyrrhiza glabra. The sources for the literature search were PubMed, ScienceDirect, SciFinder and Google Scholar. Reported pharmacological activities, characterized secondary metabolites and traditional uses of Glycyrrhiza glabra warrants its potential therapeutic uses. However, further scientific validations along with evidencebased studies are still required in support to its traditional uses, to serve as "lead" for development of novel agents and a better drug candidate in future. Keywords:

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“…107 Glycyrrhiza glabra aqueous extract markedly improves antihypoxic effects induced by sodium nitrite in rats and this effect may be mediated by its antioxidant properties. 108,109 The roots and rhizomes of Glycyrrhiza glabra is an efficient brain tonic; it increases the circulation into the CNS system and balance the sugar levels in the blood. 110 Liquorice has significant action on memory enhancing activity in dementia.…”

Section: Introductionmentioning

confidence: 99%

Rasayana Herbs of Ayurveda to Treat age Related Cognitive Decline: An Update

Kulkarni¹,

Shetty²,

N³

et al. 2016

Phcogj

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Introduction: Cognitive decline associated with aging could be minor or major neuro-cognitive disorder presenting with progressive intellectual deterioration interfering with day to day activities. Behaviour and personality changes may complicate the life in due course. Significant increase in global prevalence of people aged above 60 years has raised concerns on effective management of old age problems. Age related cognitive deficits and dementia raise to the level of epidemics and established management is yet underway. Principles of preventive health and rasayana (rejuvenative) herbs of Ayurveda are being extensively researched up on for their effectiveness in dementia. In this fourteen such herbs with anti dementia property are discussed with relevant research update. Methods: Herbs like amalaki (Emblica officinalis), hareetaki (Terminalia chebula), haridra (Curcuma longa), manduka parni (Centella asiatica), aindri (Bacopa monniera), yastimadhu (Glycirrhiza glabra), guduchi (Tinospora cordifolia), shankhapushpi (Convolvulus pleuricaulis), vacha (Acorus calamus), jyotishmati (Celastrus panniculata), kushmanda (Benincasa hispida), Jatamamsi (Nardostachys jatamamsi), ashvagandha (Withania somnifera) and kapikacchu (Mucuna pruriens (Linn.)) are already proven of their efficacy in experimental and preclinical levels. The contents and research evidences are collected from ayurveda database on medicinal plants used in Ayurveda and Siddha and other authentic literature, Google scholar, Science direct, online and print journals. Discussion: The herbs in discussion mostly act on reactive oxygen species and oxidative stress injury by antioxidant properties and neuro-

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Cerebroprotective effect of Glycyrrhiza glabra Linn. root extract

Cited by 24 publications

References 19 publications

Herbal Medicines as Neuroprotective Agent: A Mechanistic Approach

Herbal Medicines as Neuroprotective Agent: A Mechanistic Approach

Pharmacological Perspective of Glycyrrhiza glabraLinn.: a Mini-Review

Rasayana Herbs of Ayurveda to Treat age Related Cognitive Decline: An Update

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