Rasayana Herbs of Ayurveda to Treat age Related Cognitive Decline: An Update

Kulkarni, Reena; Shetty, Suhas Kumar; N, Rajarajeshwari; Rao, Prasanna N; Nayan, J

doi:10.5530/pj.2016.5.1

Cited by 4 publications

(5 citation statements)

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“…The major bioactive curcumin from the rhizome is reported as an antioxidant with potential neuroprotective properties. [88,149] As there is a long history of employing traditional Chinese plants in vitro. [102] The whole root of Scrophularia ningpoensis Hemsl.…”

Section: Aerial Partsmentioning

confidence: 99%

“…A wide number of in vivo, in vitro and clinical evidence substantiate and support its nootropic ability. [ 149 ] Similarly, Centella asiatica (L.) Urb. is also well known among the Indian systems of traditional medicines for its neuroprotective and nootropic properties which are further scientifically supported.…”

Section: Medicinal Plants As Aβ and Tau Aggregation Inhibitorsmentioning

confidence: 99%

“…The major bioactive curcumin from the rhizome is reported as an antioxidant with potential neuroprotective properties. [ 88,149 ]…”

Section: Medicinal Plants As Aβ and Tau Aggregation Inhibitorsmentioning

confidence: 99%

“…Different pharmacological properties of the plant have also been reported from the plant such as antibacterial, antihypertensive, antifungal, neuroprotective, cardioprotective, anticonvulsant, and anti‐inflammatory in recent studies. [ 149 ] Gastrodia elata Blume is another traditional herb that is recorded in Chinese Materia Medica as a medicine and in Sichuan cuisine used to ‘calm the liver’ and for treating headaches, tetanus, and epilepsy. It is also used as pain reliever and inflammatory‐mediating activities.…”

Section: Medicinal Plants As Aβ and Tau Aggregation Inhibitorsmentioning

confidence: 99%

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Ethnobotanical significance of medicinal plants: Beta‐amyloid and tau aggregation inhibitors against Alzheimer's disease

Ganapathy

Haripriya

Acharya

et al. 2023

J Biochem & Molecular Tox

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Among the various neurodegenerative disorders, Alzheimer's disease (AD) is identified as one of primary causes of dementia in the elderly, which progresses slowly leading to cognitive decline and ability to function independently. Although various pathological mechanisms have been proposed, the exact mechanism is not yet elucidated. Numerous processes such as old age, mitochondrial dysfunction, and genetics lead to the aggregation of beta-amyloid (Aβ) as amyloid plaques and tau proteins as neurofibrillary tangles in the neurons leading to their death and destruction, finally leading to AD. The current treatment measures can only temporarily improve the symptoms, slowing cognitive decline without any effect on AD pathology for better therapeutic effect. Furthermore, the high failure rates of a number of drugs during clinical trials due to their side effects has led the researchers to focus on alternative sources for drug development. As natural ingredients were considered the primary line of treatment in the olden days, and as several medicinal plant products are also proven as effective AD targets, it will be wise to investigate those with significant ethnobotanical value as potential neuroprotectives, nootropics or memory boosters. Throughout the study, propanoids, glycosides, iridoids, carotenoids and flavonoids that show potential anti-inflammatory, antioxidant, and anti-cholinesterase were also found to be inhibitors of Aβ and tau aggregation, where Saikosaponin C, Fisetin, and Morin can act as dual inhibitors. The review provides an insight in the need for proper and complete scientific evaluation of these ethnobotanically useful medicinal plants to be identified as potential leads in AD therapy.

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Section: Aerial Partsmentioning

confidence: 99%

Section: Medicinal Plants As Aβ and Tau Aggregation Inhibitorsmentioning

confidence: 99%

“…The major bioactive curcumin from the rhizome is reported as an antioxidant with potential neuroprotective properties. [ 88,149 ]…”

Section: Medicinal Plants As Aβ and Tau Aggregation Inhibitorsmentioning

confidence: 99%

Section: Medicinal Plants As Aβ and Tau Aggregation Inhibitorsmentioning

confidence: 99%

See 2 more Smart Citations

Ethnobotanical significance of medicinal plants: Beta‐amyloid and tau aggregation inhibitors against Alzheimer's disease

Ganapathy

Haripriya

Acharya

et al. 2023

J Biochem & Molecular Tox

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“…The drugs like ashwagandha (Withania somnifera), shankhapushpi (Clitoria ternatea), yashtimadhu(Glycyrrhiza glabra), brahmi (Bacopa monnieri), guduchi(Tinospora cordifolia), mandookaparni(Centella asiatica), jyotishmati (Celastrus paniculata), vacha(Acorus calamus), jatamamsi (Valeriana jatamansi) are widely used in the management of stress for its anxiolytic property. Among these ashwagandha is considered to be the best adaptogenic drug among medhya dravya (cognitive enhancers) 12 …”

Section: Stress In Ayurvedamentioning

confidence: 99%

A Review on Adaptogenic Activity of Ashwagandha (Withania Somnifera): An Ayurvedic Appraisal

Shrilata¹,

Kumar²,

Chand³

et al. 2017

J Pharm Sci Innov.

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Stress is a state of mental or emotional strain resulting from demanding circumstances. It's a universal experience, which has an important defensive function towards harmful psychological stimuli. Owing to this there are various pharmacological and non-pharmacological treatments with fatal adverse reaction. The need of hour is to have a cost-effective adaptogenic drug. Adaptogens are compounds that increase the ability of an organism to adapt to environmental factors and avoid damage. Ayurveda explains these qualities under concepts of vyadhikshamatva (immunity). Ashwagandha is considered to be the best adaptogenic drug among shankhapushpi (Clitoria ternatea), yashtimadhu (Glycyrrhiza glabra), brahmi (Bacopa monnieri), guduchi (Tinospora cordifolia), mandookaparni (Centella asiatica), etc medhya dravya (cognitive enhancers). This study reviews the Ayurvedic and modern literature related to stress and its management as adaptogens through Ayurveda. Ayurveda is the traditional system of medicine of India and contains a very scientific description of stress and general manovikaras (psychiatric illness). Ayurveda has been a great potential in the field of rasayana (rejuvenation) as there are lots of single herbs and preparations which possess adaptogenic properties and strengthens the physiological adaptation.

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