Hyperplasie angio-Iymphoïde avec mucinose folliculaire

Bovet, R; Delacretaz, J

doi:10.1159/000250778

Cited by 9 publications

(2 citation statements)

References 2 publications

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“…The recent identification of a unique precursor to CMM in high-risk family members (4-6) has provided new research opportunities. Designated the dysplastic nevus syndrome (DNS) (7), because cytologic atypia of melanocytes is its histologic hallmark, this disorder forms the substrate from which most cases of familial CMM arise (8)(9)(10)(11)(12)(13)(14)(15). Here we present segregation and linkage analyses of a series of 14 melanoma-prone kindreds, which document that the distribution of CMM and DNS in families is consistent with an autosomal dominant mode of inheritance and suggest that the DNS/CMM susceptibility gene is linked to the Rh locus.…”

mentioning

confidence: 99%

Familial cutaneous malignant melanoma: autosomal dominant trait possibly linked to the Rh locus.

Greene¹,

Goldin²,

Clark³

et al. 1983

Proc. Natl. Acad. Sci. U.S.A.

143

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Segregation and linkage analyses were undertaken in families with multiple cases of cutaneous malignant melanoma (CMM) and a recently-described melanoma precursor, the dysplastic nevus syndrome (DNS). Clinical and laboratory data, including 23 genetic markers, were collected on 401 members of 14 high-risk kindreds. Pedigree analysis was compatible with an autosomal dominant mode of inheritance for the familial CMM trait. Although a similar model probably applies to the DNS trait as well, segregation analysis could not confirm the presence of a major locus. However, linkage analysis suggested that an autosomal dominant model was appropriate for the DNS, and that a DNS/CMM susceptibility gene may be located on the short arm of chromosome 1, within 30 map units of the Rh locus [maximum logarithm of odds (lod) score = 2.00].Writing in 1820, Sir William Norris presented a vivid description of the familial variant of cutaneous malignant melanoma (CMM) (1). He concluded, "These facts . . . would incline me to believe that this disease is hereditary." Modem investigations of familial melanoma began with the seminal work of E. P. Cawley (2), and it is now clear that familial melanoma is not uncommon (3), but to date there have been no formal genetic studies of familial CMM. The recent identification of a unique precursor to CMM in high-risk family members (4-6) has provided new research opportunities. Designated the dysplastic nevus syndrome (DNS) (7), because cytologic atypia of melanocytes is its histologic hallmark, this disorder forms the substrate from which most cases of familial CMM arise (8-15). Here we present segregation and linkage analyses of a series of 14 melanoma-prone kindreds, which document that the distribution of CMM and DNS in families is consistent with an autosomal dominant mode of inheritance and suggest that the DNS/CMM susceptibility gene is linked to the Rh locus. METHODSClinical Survey. The Cancer-Prone Family Registry, maintained by the Family Studies Section of the Environmental Epidemiology Branch, National Cancer Institute (16), is a nonpopulation-based series of malignancy-prone kindreds referred by physicians of the National Institutes of Health, community practitioners around the United States, and concerned family members. When this study began, there were approximately 1,000 families in the Registry, from which all kindreds with at least two living, pathologically confirmed cases of CMM were identified; the 25 kindreds found were listed in ascending numerical order by date of ascertainment. Families were contacted, seriatim, and offered an opportunity to participate in a combined clinical-laboratory evaluation of familial melanoma. Fourteen kindreds were studied; available data suggest that the remaining families are similar to those that were included. We examined, photographed, and obtained blood samples from all melanoma probands, from all additional living family members with melanoma, and from 97% of their first-degree relatives; in many cases, more distant relatives were...

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mentioning

confidence: 99%

Familial cutaneous malignant melanoma: autosomal dominant trait possibly linked to the Rh locus.

Greene¹,

Goldin²,

Clark³

et al. 1983

Proc. Natl. Acad. Sci. U.S.A.

143

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“…359 A congenital case has been reported. [370][371][372][373][374] Rarely, patients with leukemia cutis, 375 leukemia without skin lesions, 376 Hodgkin's disease, 377 familial reticuloendotheliosis, 378 Sézary syndrome, 379,380 squamous cell carcinoma of the tongue, 381 and angiolymphoid hyperplasia 382,383 have also had this presentation. [370][371][372][373][374] Rarely, patients with leukemia cutis, 375 leukemia without skin lesions, 376 Hodgkin's disease, 377 familial reticuloendotheliosis, 378 Sézary syndrome, 379,380 squamous cell carcinoma of the tongue, 381 and angiolymphoid hyperplasia 382,383 have also had this presentation.…”

Section: Follicular Mucinosis (Alopecia Mucinosa)mentioning

confidence: 99%

Cutaneous mucinoses

Weedon

2010

Weedon's Skin Pathology

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Ringworm of the Chin

Strumìa

1989

Arch Dermatol

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A 13-year-old girl presented with a prominent, erythematous, desquamative plaque of 3 cm in diameter on the left part of her chin (Fig 1). The lesion, which she had had for three months, was slowly enlarging in spite of the use of topical steroids and antimycotic agents. She was in good general health and results of routine examination were normal. Results of microscopic examination and culture of the scale for detection of fungal elements were negative. A cutaneous biopsy specimen showed the pattern in Fig 2.

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Hyperplasie angio-Iymphoïde avec mucinose folliculaire

Abstract: Association of angiolymphoid hyperplasia (pseudopyogenic granuloma type) and follicular mucinosis in the same lesion on the scalp of a 30-year-old woman. A similar case has been reported recently.

Cited by 9 publications

References 2 publications

Familial cutaneous malignant melanoma: autosomal dominant trait possibly linked to the Rh locus.

Familial cutaneous malignant melanoma: autosomal dominant trait possibly linked to the Rh locus.

Cutaneous mucinoses

Ringworm of the Chin

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