Hyperinsulinaemia and decreased plasma levels of dehydroepiandrosterone sulfate in premenopausal women with coronary heart disease

Słowińska-Srzednicka, J; Malczewska, B; Srzednicki, M.; Chotkowska, E; Brzezińska, Agnieszka; Zgliczyński, Wojciech; Ossowski, Marcin; Jeske, Wojciech; Zgliczyński, S; Sadowski, Zygmunt

doi:10.1111/j.1365-2796.1995.tb00871.x

Cited by 40 publications

(16 citation statements)

References 42 publications

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“…A favorable effect through conversion of DHEA-S to estradiol (38) may also contribute to the improvement of endothelial function. Interestingly, a negative relationship between DHEA-S, coronary artery disease (CAD) and atherosclerosis has been documented in cross sectional studies in young women (39,40,41).…”

Section: Discussionmentioning

confidence: 99%

Association of dehydroepiandrosterone-sulfate with endothelial function in young women with polycystic ovary syndrome

Dagre

Lekakis²,

Mihas³

et al. 2006

eur j endocrinol

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Objective: The aim of this study was to assess non-invasively endothelial function of young women with polycystic ovary syndrome (PCOS) in comparison with healthy age-matched women and a group of young women with idiopathic hirsutism (IH). The possible role of metabolic and hormonal parameters on endothelial function was also examined. Design: Descriptive clinical trial. Methods: Fifty-six women, 27 with PCOS, 16 with IH and 13 healthy age-matched women were studied. Endothelial function of resistance arteries was assessed by venous occlusion plethysmography. Metabolic and hormonal parameters were estimated in this study population. Results: The duration of reactive hyperemia (durRH) was shorter in PCOS group when compared with normal controls (63.75G13.33 s vs 113.18G20.92 s, PZ0.036). A similar finding was observed when PCOS were compared with IH group (63.75G13.33 s vs 105G17.20 s, PZ0.05). The durRH did not differ between IH and control group (105G17.20 s vs 113.18G20.92 s, ns). A significant positive linear correlation was found between the durRH and dehydroepiandrosterone-sulfate (DHEA-S) levels (rZC0.48, PZ0.04) in the PCOS group. The basal insulin resistance index (HOMA) differed significantly between PCOS, IH and control groups. There was no significant correlation between durRH and HOMA index or testosterone levels in the PCOS group. Conclusions: Endothelial dysfunction may be an early sign of cardiovascular system abnormalities in young PCOS women. It is possible that increased DHEA-S levels may offer a cardioprotective advantage that attenuates the effects of cardiovascular risk factors that accompany PCOS.European Journal of Endocrinology 154 883-890

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Section: Discussionmentioning

confidence: 99%

Association of dehydroepiandrosterone-sulfate with endothelial function in young women with polycystic ovary syndrome

Dagre

Lekakis²,

Mihas³

et al. 2006

eur j endocrinol

View full text Add to dashboard Cite

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“…Slowinska-Srzednicka and colleagues studied 21 women who had sustained a myocardial infarction and had coronary artery stenosis on angiography and compared them with 14 women with an abnormal exercise stress test but normal coronary arteries and nine healthy women (65). All women were premenopausal.…”

Section: Cardiovascular Effects Epidemiological Studiesmentioning

confidence: 98%

Safety of testosterone treatment in postmenopausal women

Braunstein¹

2007

Fertility and Sterility

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“…Furthermore, studies dealing with the relation of DHEA(S) levels and cardiovascular diseases revealed inconsistent re-sults. For instance, Slowinska-Srzednicka et al (162) reported decreased DHEAS levels in premenopausal women with coronary heart disease, whereas other studies did not suggest a protective role of DHEA(S) (144,176). Interestingly, an increased risk of cardiovascular diseases was also found in women with hirsuitism and polycystic ovary syndrome (PCOS), diseases which are correlated with higher testosterone levels (27,28,45,187).…”

Section: Androgen Plasma Levels and Cardiovascular Diseasesmentioning

confidence: 99%

Cardiovascular Effects of Androgens

Weidemann

Hanke

2002

Cardiovascular Drug Reviews

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In the process of atherosclerosis sex steroids play a complex role in the vascular vessel wall system. Although a number of experimental studies have clearly documented an atheroprotective effect of estrogens, in recent clinical studies, estrogen replacement therapy has failed to reduce cardiovascular mortality. The effects of androgens on the cardiovascular system and cardiovascular diseases are even more controversial. Whereas in the past, androgens were mainly believed to exert adverse effects on the cardiovascular system, recent studies in men have documented a number of beneficial actions of testosterone in the arterial vascular system. Androgens affect lipid metabolism (e.g., LDL and HDL cholesterol, Lp(a)) and hemostasis (e.g., platelet aggregation and fibrinolytic activity). In addition, several other physiological and pathophysiological processes in the arterial vessel wall are influenced by androgens. Acute hemodynamic effects of testosterone on coronary vasomotion and stress-test-induced ischemia were reported. Additionally, recent animal and in vitro studies have further documented an inhibitory effect of androgens on neointimal plaque formation. This review discusses different and, in part, contradictory effects of androgens on the cardiovascular system including potential signal transduction pathways in androgen target cells.

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Hyperinsulinaemia and decreased plasma levels of dehydroepiandrosterone sulfate in premenopausal women with coronary heart disease

Abstract: In premenopausal women, hyperinsulinaemia and decreased DHEA-S levels may contribute to the development of coronary atherosclerosis.

Cited by 40 publications

References 42 publications

Association of dehydroepiandrosterone-sulfate with endothelial function in young women with polycystic ovary syndrome

Association of dehydroepiandrosterone-sulfate with endothelial function in young women with polycystic ovary syndrome

Safety of testosterone treatment in postmenopausal women

Cardiovascular Effects of Androgens

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