Association of dehydroepiandrosterone-sulfate with endothelial function in young women with polycystic ovary syndrome

Dagre, Anna; Lekakis, John; Mihas, Costas; Protogerou, Athanase D.; Thalassinou, L; Tryfonopoulos, Dimitrios; Douridas, Gerasimos; Papamichael, C.; Alevizaki, Maria

doi:10.1530/eje.1.02153

Cited by 22 publications

(25 citation statements)

References 59 publications

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“…Consistent with our results, most of the studies, but not all [8,12], demonstrated impaired endothelial function in PCOS using either noninvasive endothelium-dependent (FMD) and-independent (glyceroltrinitrate, GTN) changes in the brachial artery or invasive methodology [4,6,10,11,24] compared with the controls. Among several circulating endothelium-derived vasoactive molecules, ET-1 is considered one of the best indices of abnormal vascular reactivity, playing an important role in the early events of endothelial dysfunction [4].…”

Section: Discussionsupporting

confidence: 89%

“…Conflicting results have been provided regarding the factors associated with impaired vascular reactivity in PCOS. The relationship with hyperandrogenemia is especially controversial, since the effect of the androgens was described as either adverse [10,25], neutral [24,26], or even protective in patients with PCOS [27]. However, the reports are more constant with regard to ET-1 and the deleterious effect that markers of hyperandrogenemia have on it [3,9,10].…”

Section: Discussionmentioning

confidence: 99%

“…A control group composed of 32 women (age: 23.06 ±5.37 (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34), BMI: 25.87± 6.89 (16.88-42.86) kg/m 2 ) was selected as to be similar to the group of patients in terms of age and BMI. In the end though, our intention was not fully accomplished because there was still a significant difference in BMI between the groups.…”

Section: Study Protocolmentioning

confidence: 99%

See 2 more Smart Citations

The polycystic ovary syndrome (pcos) status and cardiovascular risk in young women

Ilie¹,

Pepene²,

Marian³

et al. 2010

Open Medicine

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AbstractThe study investigated the presence of early vascular damage and chronic inflammation, and their relationships with hormonal and metabolic parameters in 45 young women with PCOS in comparison with thirty-two healthy age-matched controls. Hormonal and metabolic profiles, high sensitivity C-reactive protein (hsCRP), tumoral necrosis factor-alpha (TNF-α), endothelin-1 (ET-1), brachial flow-mediated vasodilation (FMD) and carotid intima-media thickness (CIMT) were determined in both groups. Compared with the controls, women with PCOS had significantly lower FMD and respectively higher ET-1 levels (p=0.001). No differences were observed between the groups in terms of CIMT or inflammatory markers. In the PCOS group, ET-1 levels were significantly correlated with only testosterone concentrations (r = 0.31, p = 0.037), whereas the hsCRP levels were independently predicted only by body mass index (BMI). Within the total group, the PCOS status was the sole significant predictor of ET-1 levels and the only independent predictor of FMD. In conclusion, there is evidence of endothelial dysfunction associated with increased levels of androgen hormones in young women with PCOS. The combination of endothelial dysfunction and coexistent obesity promoting inflammation contributes to the progression of atherogenesis in PCOS. The PCOS status should be regarded as a predictor marker of cardiovascular risk, along with well-known cardiovascular risk factors.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Study Protocolmentioning

confidence: 99%

See 1 more Smart Citation

The polycystic ovary syndrome (pcos) status and cardiovascular risk in young women

Ilie¹,

Pepene²,

Marian³

et al. 2010

Open Medicine

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“…Plasma DHEA-S levels do not drop during the menopause transition, but decline with aging (1,2,20). A recent study has shown a positive correlation between DHEA-S levels and the duration of reactive hyperemia, another less specific marker of endothelial function compared to FMD, in young women (26±6 years old, n= 27) with polycystic ovary syndrome (21). In postmenopausal women, however, a correlation between DHEA-S levels and endothelial vasomotor function has not yet been reported.…”

Section: Discussionmentioning

confidence: 92%

Association of Plasma Dehydroepiandrosterone-Sulfate Levels with Endothelial Function in Postmenopausal Women with Coronary Risk Factors

et al. 2008

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“…Height and weight were measured and endothelial function was tested, as described below. Endothelial function of the resistance vessels was assessed by measuring forearm blood flow (FBF) before and after upper arm arterial occlusion (21)(22)(23)(24). The stable isotope labeled frequently-sampled intravenous glucose tolerance test and minimal modeling were used to assess insulin secretion and secretion (25).…”

Section: Protocolmentioning

confidence: 99%

Impaired Endothelial Function in Healthy African-American Adolescents Compared with Caucasians

Duck

Hoffman

2007

The Journal of Pediatrics

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Objective-To determine whether African-American adolescents have endothelial dysfunction compared to Caucasians and whether differences are due to differences in insulin sensitivity (S I ) or secretion.Study design-Thirty-three Caucasian (age, 13.6±2.6 yr; BMI 21.6±4.4 kg/m 2 mean ±SD) and 25 African-American (13.3±2.9 yr; 24.0±4.4 kg/m 2 ) adolescents were studied. Forearm blood flow (FBF, plethysmography) was measured before and after 5 min of arterial occlusion. S I and acute insulin response to glucose (AIRG) were measured using intravenous glucose tolerance tests and minimal modeling.Results-Baseline FBF did not differ between races. Post-occlusion FBF was lower in AfricanAmericans (17.2±1.2 versus 22.6±1.2 ml/dl/min, p=0.006). AIRG was higher in African-Americans (6050±940 versus 2410±30 μU min/ml, p=0.001). Pubertal stage had no effect. S I did not differ by race or pubertal stage. In African-Americans, percent fall in forearm vascular resistance following arterial occlusion correlated (r=0.67 p=0.001) with logAIRG. No relationships were found between percent fall in FVR and S I in either race.Conclusion-African-American adolescents have decreased endothelial function. This may be due to increased insulin secretion. Endothelial dysfunction in African-American adolescents may predispose to cardiovascular and type 2 diabetes. Keywords insulin sensitivity; insulin secretion; puberty African-American adults have increased morbidity and mortality from most of the diseases associated with the metabolic syndrome, including myocardial infarction at younger ages (1-4), stroke (5,6), hypertension (3), and type 2 diabetes in both adults and adolescents (3,7,8 Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Mechanistically, there is a close link between endothelial function and insulin sensitivity in both normotensive and hypertensive subjects (16,17). This is important because African American adolescents are more frequently insulin resistant compared to Caucasians (18,19). We therefore hypothesized that: 1) Since insulin sensitivity is decreased in African-American adolescents endothelial function would also be lower in African-American adolescents; 2) Since insulin sensitivity is lower in pubertal than in prepubertal and postpubertal subjects (20), endothelial function would also be lower in pubertal subjects than in prepubertal or postpubertal subjects, and 3) Endothelial function would be positively associated with muscle insulin sensitivity. NIH Public Access Methods SubjectsHealthy, adolescent volunteers between 8 and 18 years of age were recruited for participa...

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Association of dehydroepiandrosterone-sulfate with endothelial function in young women with polycystic ovary syndrome

Cited by 22 publications

References 59 publications

The polycystic ovary syndrome (pcos) status and cardiovascular risk in young women

The polycystic ovary syndrome (pcos) status and cardiovascular risk in young women

Association of Plasma Dehydroepiandrosterone-Sulfate Levels with Endothelial Function in Postmenopausal Women with Coronary Risk Factors

Impaired Endothelial Function in Healthy African-American Adolescents Compared with Caucasians

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