Hyperbaric Oxygen Reduces the Progression and Accelerates the Regression of Atherosclerosis in Rabbits

Abstract

Abstract-We studied the effect of hyperbaric oxygen (HBO) treatment on the extent of diet-induced accumulation of lipid oxidation products in rabbit plasma and tissues, on plasma paraoxonase activity, and on the extent of progression and regression of atherosclerotic lesions in the rabbit aorta. HBO treatment of cholesterol-fed rabbits dramatically reduces the development of arterial lesions despite having little or no effect on plasma or individual lipoprotein cholesterol concentrations. Compared with no treatment in cholesterol-fed animals, HBO treatment also substantially reduces the accumulation of lipid oxidation products (conjugated dienes, trienes, and thiobarbituric acid-reactive substances) in plasma, in the low density lipoprotein and high density lipoprotein fractions of plasma, in the liver, and in the aortic tissues. In addition, HBO treatment prevents the decrease in plasma paraoxonase activity observed in rabbits fed cholesterol-rich diets. Similarly, in regression studies, HBO treatment has no effect on the rate of plasma (or lipoprotein) cholesterol decline but significantly accelerates aortic lesion regression compared with no treatment. Direct measures of aortic cholesterol content support these morphological observations. On the basis of these results, we conclude that repeated, but relatively short, exposure to HBO induces an antioxidant defense mechanism(s) that is responsible for retarding the development or accelerating the regression of atherosclerotic lesions.

Hyperbaric Oxygen Therapy (HBOT) as a Therapeutic Option for Patients with Atopic Dermatitis (AD) – Own Experiences and Literature Review

“…Similarly, currently presented results indicate both a beneficial therapeutic effect, manifested by a subjective and objective improvement of the clinical condition of the patients, as well as an inhibitory effect on the dynamics of changes in the tested laboratory parameters, particularly immunoglobulin E and C3 complement component. Furthermore, these observations are consistent with the findings of other researchers dealing with the use of hyperbaric oxygenation as a therapeutic option for other groups of diseases associated with an immune activation and inflammatory cascade [11,15,16,17,18,19,20,21].…”

O pólo inferior do baço de ratos e a oxigenoterapia hiperbárica

“…Considerando que a OHB tem efeito benéfico no processo inflamatório [30][31][32][33][34][35][36] , que ela estimula a circulação colateral 27 e tem efeito angiogênico 25,26 , é admissível que essa modalidade de tratamento tenha contribuído para melhorar a viabilidade do pólo inferior. A oxigenoterapia hiperbárica tardiamente não interferiu na viabilidade e na função conforme pudemos observar na análise dos resultados funcionais e morfológicos.…”

“…No Brasil, a Resolução CFM 1457/95 do Conselho Federal de Medicina regulamentou seu uso nas seguintes indicações: embolia gasosa, embolia traumática pelo ar, envenenamento por monóxido de carbono, gangrena gasosa clostridiana, doença de Fournier, isquemias agudas traumáticas, queimaduras térmicas ou elé-tricas, lesões por irradiação, osteomielite, retalhos ou enxertos comprometidos ou de risco. No nível experimental demonstrou-se que a OHB tem efeito angiogênico 25,26 , estimula a formação de circulação colateral 27 , aumenta o conteúdo arterial de oxigênio e a elasticidade dos glóbulos vermelhos 28 , acelera a cicatrização do baço após a ligadura simultânea da artéria e veia esplênicas 29 , além de atuar beneficamente em processos inflamatórios tais como: pancreatite [30][31][32] , colite 33,34 , hepatite crônica 35 e aterosclerose 36 .…”

Therapeutic effect of hyperbaric oxygen in psoriasis vulgaris: two case reports and a review of the literature

“…Psoriasis vulgaris is a T-cell-driven disease, with type I (interferon-γ-producing) T cells predominating in skin lesions [10,11]. A lymphocytic infiltrate in psoriasis plaques consists of a mixture of activated CD4 + and CD8 + T cells; the latter predominate in lesional epidermis and CD4 + cells in the dermis [12]. The therapeutic benefit of immunosuppressive drugs supports the view that activated T cells are pathogenic effectors of psoriasis [10].…”

“…HBO 2 suppresses the proliferation of macrophages and the formation of foam cells in atherosclerotic lesions [12]. HBO 2 also intensifies the suppressive function of T lymphocytes, normalizes cell-bound immunity, and decreases the serum concentration in immune complexes [13].…”