Hydroxypropylmethyl cellulose (HPMC) crosslinked chitosan (CH) based scaffolds containing bioactive glass (BG) and zinc oxide (ZnO) for alveolar bone repair

Zeeshan, Rabia; Mutahir, Zeeshan; Iqbal, Haffsah; Ali, Moazzam; Iqbal, Farasat; Ijaz, Kashif; Sharif, Faiza; Shah, Asma Tufail; Chaudhry, Aqif Anwar; Yar, Muhammad; Luan, Shifang; Khan, Ather Farooq; Ihtesham-ur-Rehman,

doi:10.1016/j.carbpol.2018.03.046

Cited by 52 publications

(17 citation statements)

References 34 publications

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“…The cells were cultured in the CO 2 incubator at 37 °C and 5% CO 2 for 72 h. Then, the culture medium was replaced by 1 mL of calcein solution (0.1 μM), and the scaffolds with cells were incubated for another 0.5 h. The living cells within the scaffolds were stained and observed by the inverted fluorescence microscope. 57 Cell Adhesion within the Scaffolds. The scaffolds were cut into circular discs with 1 mm in height and 4 mm in diameter and sterilized in 75% ethanol for 24 h and then washed three times with PBS.…”

Section: ■ Introductionmentioning

confidence: 99%

Emulsion Template Method for the Fabrication of Gelatin-Based Scaffold with a Controllable Pore Structure

Long

et al. 2018

ACS Appl. Mater. Interfaces

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The porous microstructure of scaffolds is an essential consideration for tissue engineering, which plays an important role for cell adhesion, migration, and proliferation. It is crucial to choose optimum pore sizes of scaffolds for the treatment of various damaged tissues. Therefore, the proper porosity is the significant factor that should be considered when designing tissue scaffolds. Herein, we develop an improved emulsion template method to fabricate gelatinbased scaffolds with controllable pore structure. Gelatin droplets were first prepared by emulsification and then solidified by genipin to prepare gelatin microspheres. The microspheres were used as a template for the fabrication of porous scaffolds, which were gathered and tightened together by dialdehyde amylose. The results showed that emulsification can produce gelatin microspheres with narrow size distribution. The size of gelatin microspheres was easily controlled by adjusting the concentration of gelatin and the speed of mechanical agitation. The gelatin-based scaffolds presented macroporous and interconnected structure. It is interesting that the pore size of scaffolds was directly related to the size of gelatin microspheres, displaying the same trend of change in size. It indicated that the gelatin microspheres can be used as the proper template to fabricate gelatin-based scaffold with a desired pore structure. In addition, the gelatin-based scaffolds possessed good blood compatibility and cytocompatibility. Overall, the gelatin-based scaffolds exhibited great potential in tissue engineering.

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Section: ■ Introductionmentioning

confidence: 99%

Emulsion Template Method for the Fabrication of Gelatin-Based Scaffold with a Controllable Pore Structure

Long

et al. 2018

ACS Appl. Mater. Interfaces

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“…Cellulose, alginate, chitosan, hyaluronic acid, collagen, keratin, silk, and pullulan are natural polymers used to make biodegradable scaffolds for bone tissue engineering. Cellulose extracted from the plant and bacterial cell walls has been widely used in composite with several materials, such as pullulan (Figure 4), 91 chitosan, 92 alginate, 93 and HAp. 94,95 The unique gelling properties of alginate have made them useful in producing injectable bone substitutes [96][97][98] and bone wax.…”

Section: Natural Polymersmentioning

confidence: 99%

A novel classification of bone graft materials

2022

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Over the past few decades, the field of biomaterials concerning bone tissue engineering has gained a significant amount of interest. This has led to new biomaterials to be used as bone substitute materials. Despite the rapid increase in the types and forms of bone substitutes, a comprehensive classification encompassing all types of bone graft materials that have so far been developed and evaluated is lacking. Therefore, this review aims to integrate and bring together the published data on bone substitutes within the last 5 years and produce a novel classification that would provide bone material researchers with a better understanding of what materials have so far been used and evaluated and the areas, where research is lacking and deserves more attention. The literature available in all major databases was obtained and filtered using an elimination criterion to extract all the articles related to studies that tested bone substitute materials in nonclinical and clinical trials over the last 5 years. The review article would provide bone material researchers with an insight into the materials that have been evaluated for bone tissue engineering applications and identify future perspectives for bone graft material research.

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“…HPMC crosslinked, highly porous keratin scaffolds containing nanocrystalline hydroxyapatite as major inorganic component were fabricated by using a freeze-drying technique. HPMC is a hydrophilic, biodegradable polymer which is approved by United States Food and Drug Administration (FDA) for use in controlled release formulations [ 48 ]. The presence of HPMC provides additional sites of interaction for keratin and hydroxyapatite particles and thus aid in the formation of highly porous anisotropic structure.…”

Section: Introductionmentioning

confidence: 99%

“…reported the preparation and characterization of highly porous chitosan/HA scaffolds using HPMC as a gelation agent [ 52 ]. Furthermore, another study reported the preparation of HPMC cross-linked chitosan scaffolds as a potential matrices for regeneration of alveolar bone [ 48 ]. As per our knowledge there is no study conducted so far to explore the application of HPMC as cross-linking agent for developing keratin derived scaffolds for bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

Hydroxypropylmethyl cellulose (HPMC) crosslinked keratin/hydroxyapatite (HA) scaffold fabrication, characterization and in vitro biocompatibility assessment as a bone graft for alveolar bone regeneration

Feroz

Dias

2021

Heliyon

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Hydroxypropylmethyl cellulose (HPMC) crosslinked chitosan (CH) based scaffolds containing bioactive glass (BG) and zinc oxide (ZnO) for alveolar bone repair

Cited by 52 publications

References 34 publications

Emulsion Template Method for the Fabrication of Gelatin-Based Scaffold with a Controllable Pore Structure

Emulsion Template Method for the Fabrication of Gelatin-Based Scaffold with a Controllable Pore Structure

A novel classification of bone graft materials

Hydroxypropylmethyl cellulose (HPMC) crosslinked keratin/hydroxyapatite (HA) scaffold fabrication, characterization and in vitro biocompatibility assessment as a bone graft for alveolar bone regeneration

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