Hydroxyapatite/mesoporous silica coated gold nanorods with improved degradability as a multi-responsive drug delivery platform

Song, Zhixuan; Yang, Lijun; Shi, Jun; Ma, Teng; Zhang, Zheng; Ma, He; Cao, Shaokui

doi:10.1016/j.msec.2017.11.012

Cited by 81 publications

(31 citation statements)

References 47 publications

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“…In the case of porous shells, another attractive feature is their ease to host additional ingredients, such as drugs, photosensitizers and reporters. Both silanized [ 65 , 202 , 203 , 204 , 205 , 206 ] and polyelectrolyte-coated [ 207 , 208 ] gold nanorods have become a popular choice to deliver and controllably release drugs and genes upon photothermal activation with exquisite control. The recent literature contains a plethora of examples of systems for multimodal therapy of cancer integrating for instance photothermal ablation and chemotherapy within the scope of the same particles [ 209 ].…”

Section: Strategies To Improve the Photostability Of Gold Nanorodsmentioning

confidence: 99%

Photostability of Contrast Agents for Photoacoustics: The Case of Gold Nanorods

et al. 2021

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Plasmonic particles as gold nanorods have emerged as powerful contrast agents for critical applications as the photoacoustic imaging and photothermal ablation of cancer. However, their unique efficiency of photothermal conversion may turn into a practical disadvantage, and expose them to the risk of overheating and irreversible photodamage. Here, we outline the main ideas behind the technology of photoacoustic imaging and the use of relevant contrast agents, with a main focus on gold nanorods. We delve into the processes of premelting and reshaping of gold nanorods under illumination with optical pulses of a typical duration in the order of few ns, and we present different approaches to mitigate this issue. We undertake a retrospective classification of such approaches according to their underlying, often implicit, principles as: constraining the initial shape; or speeding up their thermal coupling to the environment by lowering their interfacial thermal resistance; or redistributing the input energy among more particles. We discuss advantages, disadvantages and contexts of practical interest where one solution may be more appropriate than the other.

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Section: Strategies To Improve the Photostability Of Gold Nanorodsmentioning

confidence: 99%

Photostability of Contrast Agents for Photoacoustics: The Case of Gold Nanorods

et al. 2021

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“…A special focus was placed on loading capacity and controllable drug release affected by silicon derivatives. Detailed structure–property relationships were presented, including internal biological stimuli (e.g., pH, redox, enzymes) and external noninvasive stimuli (e.g., light, magnetic field, and ultrasound) [156,188].…”

Section: Si-containing Scaffolds For Stem Cell-based Bone Formationmentioning

confidence: 99%

Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation

et al. 2019

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Bioinspired stem cell-based hard tissue engineering includes numerous aspects: The synthesis and fabrication of appropriate scaffold materials, their analytical characterization, and guided osteogenesis using the sustained release of osteoinducing and/or osteoconducting drugs for mesenchymal stem cell differentiation, growth, and proliferation. Here, the effect of silicon- and silicate-containing materials on osteogenesis at the molecular level has been a particular focus within the last decade. This review summarizes recently published scientific results, including material developments and analysis, with a special focus on silicon hybrid bone composites. First, the sources, bioavailability, and functions of silicon on various tissues are discussed. The second focus is on the effects of calcium-silicate biomineralization and corresponding analytical methods in investigating osteogenesis and bone formation. Finally, recent developments in the manufacturing of Si-containing scaffolds are discussed, including in vitro and in vivo studies, as well as recently filed patents that focus on the influence of silicon on hard tissue formation.

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“…The porous nano-/microparticles are considered to be the most appropriate carriers for the drug delivery. Among them, silica, calcium carbonate and calcium phosphate are promising vehicles [6,7,8]. These particles are able to transport the huge loads of anticancer or therapeutic bioactive molecules to the desired sites for the disease treatments, owning higher efficiency and lower side effects compared to the individual drugs [9].…”

Section: Introductionmentioning

confidence: 99%

Porous Inorganic Carriers Based on Silica, Calcium Carbonate and Calcium Phosphate for Controlled/Modulated Drug Delivery: Fresh Outlook and Future Perspectives

et al. 2018

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Porous inorganic nanostructured materials are widely used nowadays as drug delivery carriers due to their adventurous features: suitable architecture, large surface area and stability in the biological fluids. Among the different types of inorganic porous materials, silica, calcium carbonate, and calcium phosphate have received significant attention in the last decade. The use of porous inorganic materials as drug carriers for cancer therapy, gene delivery etc. has the potential to improve the life expectancy of the patients affected by the disease. The main goal of this review is to provide general information on the current state of the art of synthesis of the inorganic porous particles based on silica, calcium carbonate and calcium phosphate. Special focus is dedicated to the loading capacity, controllable release of drugs under internal biological stimuli (e.g., pH, redox, enzymes) and external noninvasive stimuli (e.g., light, magnetic field, and ultrasound). Moreover, the diverse compounds to deliver with silica, calcium carbonate and calcium phosphate particles, ranging from the commercial drugs to genetic materials are also discussed.

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Hydroxyapatite/mesoporous silica coated gold nanorods with improved degradability as a multi-responsive drug delivery platform

Cited by 81 publications

References 47 publications

Photostability of Contrast Agents for Photoacoustics: The Case of Gold Nanorods

Photostability of Contrast Agents for Photoacoustics: The Case of Gold Nanorods

Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation

Porous Inorganic Carriers Based on Silica, Calcium Carbonate and Calcium Phosphate for Controlled/Modulated Drug Delivery: Fresh Outlook and Future Perspectives

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