Hydroxyapatite-ciprofloxacin delivery system: Synthesis, characterisation and antibacterial activity

Abstract

The main objective of this study was to synthesize hydroxyapatite-ciprofloxacin composites using a chemical precipitation method and to evaluate the properties and in vitro release profile of the drug from the hydroxyapatite-ciprofloxacin composites. Composite characterization was achieved by FT-IR, XRD and DLS. Ciprofloxacin determination was accomplished by HPLC, resulting in good incorporation efficiency of the drug (18.13 %). The in vitro release study (Higuchi model C = K t1/2 and Ritger-Peppas model, C = K t0.6) showed a diffusion-controlled mechanism. The antibacterial activity showed that the bacterial growth inhibition zones were approximately equal for the synthesis composites and for the mechanical mixture on the Staphylococcus aureus germ. The use of hydroxyapatite, which is a biocompatible, bioactive and osteoconductive material, with ciprofloxacin, which has good antibacterial activity in this composite, makes it suitable for the development of bone grafts. Furthermore, the synthesis process allows a slow local release of the drug.

UV-assisted synthesis of hydroxyapatite from eggshells at ambient temperature: cytotoxicity, drug delivery and bioactivity

“…Nevertheless, to gain a better understanding of the ciprooxacin ejection and associated transport phenomenon, two release kinetic models: (i) the Higuchi model (Q ¼ Kt 0.5 ); and (ii) the Ritger-Peppas model (Q ¼ Kt 0.6 ) were used to interpret the collective release percentage data. 38,39 In both models, Q represents the cumulative amount of drug released during the in vitro immersion time, t, per unit area and K is the dissolution constant characterizing the rate of drug release. The cumulative release percentage was plotted against t 0.5 and t 0.6 for the Higuchi model (inset (d) in Fig.…”

The Chemisorption-Release and Antibacterial Potential Studies of Ciprofloxacin From Hydroxyapatite-Based Implants

“…In the first 7 days of the study, 46 % of the CP was released from the HAp-CP composite, then, the released antibiotic quantity suddenly rose and almost completely delivered up to day 21. This extended release profile may be due to bonds formed between CP and HAp during synthesis [11].…”

Evaluation of Mesenchymal Stem Cells and Osteoblasts’ Adhesion and Proliferation in the Presence of HA-AL Biomaterials

“…We also had very good results when using the wet precipitation method for the synthesis of hydroxyapatite-ciprofloxacin composites [23].…”