The Chemisorption-Release and Antibacterial Potential Studies of Ciprofloxacin From Hydroxyapatite-Based Implants

Abstract

Implant infections are the result of bacterial adhesion to the implant surface and subsequent biofilm formation at the implant site. A sustained and high antibiotic concentration over minimal inhibitory concentration (MIC) of pathogenic bacteria at the implant site is expected to inhibit bacterial adhesion, colonization, and biofilm formation. In the present study we performed implants based on hydroxyapatite (HAp), HAp reinforced with titanium particles (HAp/Ti) and Hap/Ti with added calcium fructoborate (CaFb) by chemisorption deposition method (HAp/Ti/CaFb). The implants were immersed in ciprofloxacin (CP) solution for 24 hours, then was determined the release profile of antibiotic for 14 days and the antibacterial effect of the three types of composite. The period of antibiotic release may be considered as sufficient to support osteointegration under antibacterial protection.

Current Options and Future Perspectives on Bone Graft and Biomaterials Substitutes for Bone Repair, from Clinical Needs to Advanced Biomaterials Research

“…Furthermore, these effects are more intense in the case of calcium fructoborate (CaFB) adsorption on the HA/TiO 2 PM biocomposites [95,96]. The nanostructured HA matrix, which is TiO2-rutile r is responsible for other improved biocompatible perform fibroblast cells, assessed via quantitative (MTT assay) an tests in connection with morphological analysis, demonstr in comparison with HA-based ceramics.…”