Hyaluronidase, phospholipase A2 and protease inhibitory activity of plants used in traditional treatment of snakebite-induced tissue necrosis in Mali, DR Congo and South Africa

Molander, Marianne; Nielsen, Line Marie; Søgaard, Søren; Stærk, Dan; Rønsted, Nina; Diallo, Drissa; Chifundera, Kusamba; Staden, J. Van; Jäger, Anna K.

doi:10.1016/j.jep.2014.09.027

Cited by 56 publications

(47 citation statements)

References 24 publications

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“…An ethanol extract of the stem bark was shown to be antidiarrhoeal in mice [51]. Moderate inhibition of hyaluronidase and phospholipase A 2 as well as antiproteolytic activity of methanol and water extracts of B. africana was reported [52]. An acetone leaf extract was tested for some antioxidant and antiinflammatory activities, finding inhibition of 15-lipoxygenase, acetylcholinesterase and nitric oxide production, as well as radical scavenging activity in different assay systems [53].…”

Section: Burkea Africanamentioning

confidence: 99%

Ethnopharmacology, Chemistry and Biological Properties of Four Malian Medicinal Plants

Malterud

2017

Plants

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The ethnopharmacology, chemistry and pharmacology of four Malian medicinal plants, Biophytum umbraculum, Burkea africana, Lannea velutina and Terminalia macroptera are reviewed. These plants are used by traditional healers against numerous ailments: malaria, gastrointestinal diseases, wounds, sexually transmitted diseases, insect bites and snake bites, etc. The scientific evidence for these uses is, however, limited. From the chemical and pharmacological evidence presented here, it seems possible that the use in traditional medicine of these plants may have a rational basis, although more clinical studies are needed.

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Section: Burkea Africanamentioning

confidence: 99%

Ethnopharmacology, Chemistry and Biological Properties of Four Malian Medicinal Plants

Malterud

2017

Plants

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“…Hyaluronidase inhibitory activity 30,31 Hyaluronidase reacts with the substrate hyaluronic acid to released N-acetyl glucosamine. Hyaluronidase inhibition provides stability in the structure of the skin extracellular matrix because of the role of hyaluronic acid in binding and retaining water molecules.…”

Section: In Vitro Evaluation Of Cosmetic Activities 11-diphenyl-2-pimentioning

confidence: 99%

Cosmetic potentials of Prunus domestica L. leaves

et al. 2017

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“…HA inhibitors have also led to new therapeutic concepts in pathophysiological conditions, such as laryngeal or breast cancer treatment, that are associated with the hyaluronanhyaluronidase system 3,4,7 . Since the partial control of hyaluronidases possesses several important physiological functions, they have recently attracted considerable scientific interest as synthetic and natural inhibitors 4,[8][9][10][11][12] . Honey and bee products are natural materials whose antioxidant, anti-inflammatory and anti-tumoral efficacies vary depending on the flora from which they are produced.…”

Section: Introductionmentioning

confidence: 99%

Honey shows potent inhibitory activity against the bovine testes hyaluronidase

Kolaylı

Şahin

Can

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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The purpose of this study was to investigate the anti-hyaluronidase activities of honeys from different botanical origins honeys in order to determine their anti-inflammatory properties. The total phenolic contents, total flavonoids and total tannin levels of six types of honey, chestnut, oak, heather, pine, buckwheat and mixed blossom, were determined. Concentrationrelated inhibition values were tested turbidimetrically on bovine testis hyaluronidase (BTHase) as IC 50 (mg/mL). All honeys exhibited various concentration-dependent degrees of inhibition against BTHase. Inhibition values varied significantly depending on honeys' levels of phenolic contents, flavonoid and tannin. The honeys with the highest anti-hyaluronidase activity were oak, chestnut and heather. In conclusion, polyphenol-rich honeys have high anti-hyaluronidase activity, and these honeys have high protective and complementary potential against hyaluronidase-induced anti-inflammatory failures.

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Hyaluronidase, phospholipase A2 and protease inhibitory activity of plants used in traditional treatment of snakebite-induced tissue necrosis in Mali, DR Congo and South Africa

Cited by 56 publications

References 24 publications

Ethnopharmacology, Chemistry and Biological Properties of Four Malian Medicinal Plants

Ethnopharmacology, Chemistry and Biological Properties of Four Malian Medicinal Plants

Cosmetic potentials of Prunus domestica L. leaves

Honey shows potent inhibitory activity against the bovine testes hyaluronidase

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