In this study, the three powder characterization methods provided by an FT4 Powder Rheometer were evaluated applying 10 ml bulk samples of eight commonly used pharmaceutical excipients. The three methods include a compressibility, permeability and torsional shear test. The study showed that it is possible to obtain precise results with the FT4 powder rheometer. However, the accuracy is still of concern. Studies have shown that torsional shear testers in general tend to underestimate the shear properties of certain bulk solids. This trend is not systematic, but only counts for certain bulk solids. The accuracy of the tests in this study therefore needs to be further investigated.
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