Human β-defensin-2 and psoriasin, two new innate immunity targets of zinc gluconate

Poiraud, C.; Quéreux, G.; Knol, Anne-Chantal; Zuliani, Thomas; Allix, Rémy; Khammari, Amir; Dreno, Brigitte

doi:10.1684/ejd.2012.1800

Cited by 10 publications

(7 citation statements)

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“…Recent evidence shows that its antiinflammatory effects may target at peroxisome proliferatoractivated receptors-α (PPARs-α), human β-defensin-2, and psoriasin. 57,58 Several examples of nonsteroidal, noncalcineurin inhibitor agents are now available. 59 MAS063DP was the first approved by the U.S. Food and Drug Administration to alleviate atopic dermatitis and allergic contact dermatitis symptoms.…”

Section: Moisturizer For Atopic Dermatitismentioning

confidence: 99%

The Role of Moisturizers in Addressing Various Kinds of Dermatitis: A Review

et al. 2017

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Moisturizer is a major component of basic daily skin care, particularly in presence of epidermal barrier alteration and reduced epidermal water content. It is an important part of a dermatologist's strategy to maintain skin health as well as treating various dermatoses which co-exist with skin dryness and are linked to impaired skin barrier function, such as in atopic disorders as well as other types of dermatitis. Mastering the knowledge regarding mechanism of action, application, dosage, adverse effects as well as specific clinical usage of moisturizers is a must for a dermatologist in order to support their use, particularly for evidence-based, therapeutic purposes. This review discusses the use of moisturizer both for skin health maintenance as well as a definitive or adjuvant therapy for many kinds of dermatitis.

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Section: Moisturizer For Atopic Dermatitismentioning

confidence: 99%

The Role of Moisturizers in Addressing Various Kinds of Dermatitis: A Review

et al. 2017

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“…It has been shown to be efficient to treat inflammatory skin diseases such as acne vulgaris. Recent studies revealed that its antiinflammatory effects may target at peroxisome proliferator-activated receptors-α (PPARs-α), human β-defensin-2, and psoriasin [51,52].…”

Section: Zinc Gluconatementioning

confidence: 99%

Moisturizers for Patients with Atopic Dermatitis: An Overview

Sirikudta¹

2013

J Aller Ther

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Atopic dermatitis is a chronic inflammatory skin condition result from epidermal barrier defect and immune dysfunction. Not only has lesional skin increase pH and transepidermal water loss but also non-lesional skin. Regular use of moisturizers helps maintain skin hydration and improve barrier dysfunction. Active ingredients in moisturizers can be classified into occlusives, humectants, and emollients according to their properties. Agents with anti-inflammatory effects are also added. This review mainly focus on active agents in moisturizers claimed of suitable for atopic skin, in order to provide more information and aid physicians in selecting and giving advice to patients with atopic dermatitis.

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“…Medications applied in acne therapy can also modulate AMP expression. Using the ex vivo lipopolysaccharide LPS-induced inflammatory skin explant model, Poiraud et al [ 40 ] demonstrated an increased expression of hBD2 following treatment by zinc gluconate, but no changes were found in hBD4 expression [ 40 ]. Boroyava et al [ 41 ] examined the effect of isotretinoin therapy in acne on AMP expression levels with the use of RT-PCR.…”

Section: Immune Cells Participating In the Pathogenesis Of Acnementioning

confidence: 99%

The Role of Skin Immune System in Acne

Firlej

Kowalska

Szymaszek

et al. 2022

JCM

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Acne vulgaris is a skin disease that often occurs in adolescence and in young adulthood. The main pathogenic factors are hyperkeratinization, obstruction of sebaceous glands, stimulation of sebaceous gland secretion by androgens, and bacterial colonization of sebaceous units by Cutibacterium acnes, which promotes inflammation. Little is known about the role of skin immune cells in the development of acne lesions. The aim of the study was to try to understand the role of skin immune cells in the course of acne. Recent studies have shown that there are at least four major pathways by which Cutibacterium acnes interacts with the innate immune system to induce inflammation: through TLRs, activating inflammasomes, inducing the production of matrix metalloproteinases (MMPs), and stimulating antimicrobial peptide (AMP) activity. Cells of adaptive immune response, mainly Th1 and Th17 lymphocytes, also play an important role in the pathogenesis of acne. It is worth emphasizing that understanding the role of the skin’s immune cells in the pathogenesis of acne may, in the future, contribute to the application of modern therapeutic strategies that would avoid addiction to antibiotics, which would alleviate the spectrum of resistance that is now evident and a current threat.

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Human β-defensin-2 and psoriasin, two new innate immunity targets of zinc gluconate

Cited by 10 publications

References 0 publications

The Role of Moisturizers in Addressing Various Kinds of Dermatitis: A Review

The Role of Moisturizers in Addressing Various Kinds of Dermatitis: A Review

Moisturizers for Patients with Atopic Dermatitis: An Overview

The Role of Skin Immune System in Acne

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