The Role of Skin Immune System in Acne

Firlej, Ewelina; Kowalska, Wioleta; Szymaszek, Karolina; Roliński, Jacek; Bartosińska, Joanna

doi:10.3390/jcm11061579

Cited by 34 publications

(43 citation statements)

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“…Нейтрофилы были заметны при воспалении продолжительностью более 24 ч. в элементах, клинически классифицируемых как пустулы. Это может свидетельствовать о ведущей роли T-лимфоцитов в возникновении воспаления, в то время как нейтрофилы, привлекаются к месту повреждения хемотаксическими факторами, продуцирущимися Тклетками [13,15].…”

Section: материал и методы исследованияunclassified

Morphofunctional changes in human skin with acneiform dermatoses

Pustovaya

Piavchenko

Alexeeva

et al. 2023

Žurnal anatomii i gistopatologii

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The aim of this study was to study the morphofunctional changes in human skin with acneiform dermatoses.Material and methods. We studied the material obtained from 6 volunteers of both sexes aged 26 to 64 years. All subjects had signs of acneiform dermatoses. Pathologically changed areas were studied in comparison with normal skin in the same patient. The subjects were anesthetized and a piece of skin 3×3 mm2 in size was taken with the punch biopsy. After standard histological sample preparation, sections were stained with hematoxylin and eosin. The counting and morphometry of skin cell structures was carried out, the presence of lymphocytes, neutrophils, eosinophils, erythrocytes, vacuolized keratinocytes and their remnants in 6 fields of view in 3 histological slides from each patient was determined from each patient under an Axioskop 2 microscope with a ToupCam TP108500A camera and ToupView software (ToupTek , China). The criterion for the degree of destructive changes in the collagen fibers of the dermis was the determination of their thickness.Results. The morphological structure of the skin in acneiform dermatosis is characterized by a significant increase in the thickness of the spinous (93,7 [82,30; 96,35] microns), granular (28,4 [22,48; 34,44] microns) and corneum (37,8 [25,32; 46,24] microns) layers of the epidermis compared to the norm (66,1 [58,30; 69,42] microns; 6,2 [5,96; 6,63] microns; 10,6 [9,81; 11,26] microns, respectively). Near the sebaceous-follicular complex, inflammatory lymphohistiocytic infiltrates were found in the dermis, represented by lymphocytes (9,5±2,2 units p.f.v.), neutrophils (2,2±0,8 units p.f.v.), eosinophils (17,2±4,0 units p.f.v.), erythrocytes outside the vessels (6,8±1,1 units p.f.v.), vacuolated keratinocytes (22,1±5,7 units p.f.v.) and keratinocyte remnants (15,1±2,4 units p.f.v.) . The number of cells in the infiltrate significantly differed from the norm. On histological preparations of patients with acneiform dermatosis, thinning of the collagen fibers of the dermis (6,0 [4,79; 8,13] microns) was observed compared to unaffected skin (10,4 [10,01; 10,67] microns).Conclusions. Morphological changes in the skin with acneiform dermatosis are manifested by hypertrophic processes of the epidermis, thinning of the collagen fibers of the papillary dermis, the presence of leukocyte infiltrate and a violation of the integrity of the basement membrane of the sebaceous glands. These changes can lead to disruption of the integrity and functioning of the histo-hematic barrier of the skin and an increase in the area of spread of the inflammatory process.

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Section: материал и методы исследованияunclassified

Morphofunctional changes in human skin with acneiform dermatoses

Pustovaya

Piavchenko

Alexeeva

et al. 2023

Žurnal anatomii i gistopatologii

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“…Występująca w przebiegu trądziku nadprodukcja łoju i nadmierna keratynizacja naskórka, sprawia iż na skórze powstają korzystne warunki do rozwoju beztlenowej bakterii C. acnes [14].…”

Section: Układ Immunologiczny I Drobnoustrojeunclassified

“…Proces ten poprzedza powstanie zapalnych wykwitów trądzikowych. Zwiększona kolonizacja C. acnes powoduje również nadmierną odpowiedź immunologiczną za pośrednictwem poszczególnych komórek takich jak limfocyty Th1 oraz Th17, co w konsekwencji inicjuje, bądź nasila istniejący stan zapalny skóry [14]. Dochodzi do nadmiernej ekspresji cytokin prozapalnych oraz chemokin.…”

Section: Układ Immunologiczny I Drobnoustrojeunclassified

“…Dodatkowo biopsje zmian trądzikowych wykazały nadekspresję receptora TLR2 przez makrofagi, które otaczają pęcherzyki jednostki włosowo-łojowej [15]. Dlatego też obserwuje się ograniczenie wykwitów skórnych u chorych po zastosowaniu miejscowych retinoidów, które oddziałują na receptor TLR2, co w konsekwencji doprowadza do zablokowania nadmiernej odpowiedzi immunologicznej wywołanej przez bakterie C. acnes [14].…”

Section: Układ Immunologiczny I Drobnoustrojeunclassified

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Mature acne as a common female dermatosis – detailing of the endocrine system

Stepków¹

2023

Aesth Cosmetol Med

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One of the most common skin diseases in women is mature acne. The mechanisms that are responsible for the visible skin lesions are still being recognized, and it is impossible to put a single factor that is culpable for the development of this dermatosis. The aim of the article is to describe the possible pathogenesis of adult acne with a description of the disorders occurring at the level of skin cells. The main focus is directed to the particular role of the endocrine system in the development of adult acne in women over 25 years of age and related diseases such as polycystic ovarian syndrome. Current specialized and cosmetological therapies were also described.

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“…C. acnes secretes proteins such as lipases, which cause inflammation [6], or directly interacts with Toll-like receptor (TLR) 2 and TLR4 on keratinocytes and immune cells to cause inflammation [7,8]. Activation of the innate immune system by C. acnes is the cause of the inflammation [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Acute melanization of silkworm hemolymph by peptidoglycans of the human commensal bacterium Cutibacterium acnes

2022

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Cutibacterium acnes is a pathogenic bacterium that cause inflammatory diseases of the skin and intervertebral discs. The immune activation induced by C. acnes requires multiple cellular responses in the host. Silkworm, an invertebrate, generates melanin by phenoloxidase upon recognizing bacterial or fungal components. Therefore, the melanization reaction can be used as an indicator of innate immune activation. A silkworm infection model was developed for evaluating the virulence of C. acnes, but a system for evaluating the induction of innate immunity by C. acnes using melanization as an indicator has not yet been established. Here we demonstrated that C. acnes rapidly causes melanization of the silkworm hemolymph. On the other hand, Staphylococcus aureus, a gram-positive bacterium identical to C. acnes, does not cause immediate melanization. Even injection of heat-killed C. acnes cells caused melanization of the silkworm hemolymph. DNase, RNase, and protease treatment of the heat-treated C. acnes cells did not decrease the silkworm hemolymph melanization. Treatment with peptidoglycan-degrading enzymes, such as lysostaphin and lysozyme, however, decreased the induction of melanization by the heat-treated C. acnes cells. These findings suggest that silkworm hemolymph melanization may be a useful indicator to evaluate innate immune activation by C. acnes and that C. acnes peptidoglycans are involved in the induction of innate immunity in silkworms.

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The Role of Skin Immune System in Acne

Cited by 34 publications

References 50 publications

Morphofunctional changes in human skin with acneiform dermatoses

Morphofunctional changes in human skin with acneiform dermatoses

Mature acne as a common female dermatosis – detailing of the endocrine system

Acute melanization of silkworm hemolymph by peptidoglycans of the human commensal bacterium Cutibacterium acnes

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