Human endothelial progenitor cells-derived exosomes accelerate cutaneous wound healing in diabetic rats by promoting endothelial function

Li, Xiaocong; Jiang, Chunyu; Zhao, Juping

doi:10.1016/j.jdiacomp.2016.05.009

Cited by 135 publications

(109 citation statements)

References 27 publications

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“…The exosomes mediated their proangiogenic potential by activating Erk1/2 signaling in EC and by stimulating the expression of several angiogenic molecules. 92,93 …”

Section: Evs and Angiogenesismentioning

confidence: 99%

Extracellular Vesicles in Angiogenesis

Todorova

Simoncini

Lacroix

et al. 2017

Circulation Research

490

423

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During the past decade, extracellular vesicles (EVs), which include apoptotic bodies, microvesicles, and exosomes, have emerged as important players in cell-to-cell communication in normal physiology and pathological conditions. EVs encapsulate and convey various bioactive molecules that are further transmitted to neighboring or more distant cells, where they induce various signaling cascades. The message delivered to the target cells is dependent on EV composition, which, in turn, is determined by the cell of origin and the surrounding microenvironment during EV biogenesis. Among their multifaceted role in the modulation of biological responses, the involvement of EVs in vascular development, growth, and maturation has been widely documented and their potential therapeutic application in regenerative medicine or angiogenesis-related diseases is drawing increasing interest. EVs derived from various cell types have the potential to deliver complex information to endothelial cells and to induce either pro- or antiangiogenic signaling. As dynamic systems, in response to changes in the microenvironment, EVs adapt their cargo composition to fine-tune the process of blood vessel formation. This article reviews the current knowledge on the role of microvesicles and exosomes from various cellular origins in angiogenesis, with a particular emphasis on the underlying mechanisms, and discusses the main challenges and prerequisites for their therapeutic applications.

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“…The exosomes mediated their proangiogenic potential by activating Erk1/2 signaling in EC and by stimulating the expression of several angiogenic molecules. 92,93 …”

Section: Evs and Angiogenesismentioning

confidence: 99%

Extracellular Vesicles in Angiogenesis

Todorova

Simoncini

Lacroix

et al. 2017

Circulation Research

490

423

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show abstract

“…However, cells derived from different sources, including adipose mesenchymal cells and human amniotic epithelial cells, have demonstrated similar characteristics to MSCs (63). Exosomes of endothelial progenitor cells from human umbilical cord blood may also accelerate skin wound healing (64). Exosomes released from human induced pluripotent stem cell-derived MSCs have the ability of tissue repair by promoting collagen synthesis and angiogenesis (63).…”

Section: Exosomes and Skin Wound Healingmentioning

confidence: 99%

Exosomes as a novel pathway for regulating development and diseases of the skin (Review)

Liu

Wang

2018

biom rep

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Abstract. Exosomes are one of the most potent intercellular communicators, which are able to communicate with adjacent or distant cells. Exosomes deliver various bioactive molecules, including membrane receptors, proteins, mRNA and microRNA, to target cells and serve roles. Recent studies have demonstrated that exosomes may regulate the functions and diseases of the skin, which is the largest organ of the human body. The abnormal functions of the skin lead to the progression of scleroderma, melanoma, baldness and other diseases. A previous study has demonstrated that epithelial progenitor cells are rich in several subunits of exosomes that may maintain the proliferative capacity of these epithelial progenitor cells, which is essential for the development of the epidermis. Exosomes derived from human adipose mesenchymal stem cells accelerate skin wound healing by optimizing fibroblast properties; this is beneficial for the recovery of postoperative and other wounds. Exosomes derived from adipocytes promote melanoma migration and invasion through fatty acid oxidation; therefore, in the clinic, it may be possible to improve the prognosis of patients with melanoma by reducing their body fat content. Exosomes derived from keratinocytes modulate melanocyte pigmentation, which has been utilized as a novel mechanism for the regulation of pigmentation in conditions including Moynahan syndrome and albinism. Meanwhile, scleroderma patients with vascular abnormalities may experience decreased serum exosome levels; it may therefore be possible to detect the exosome content in sera in order to diagnose and treat scleroderma. In addition, the use of exosomes has been suggested to promote or enhance hair growth, which has been demonstrated to be highly effective. These studies have provided new opportunities and therapeutic strategies for understanding how exosomes regulate intercellular communication in pathological processes of the skin.

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“…These extracellular vesicles activate the angiogenic activity of vascular cells, particularly mature endothelial cells, through horizontal transfer of signaling molecules. Exposure to EPC-derived exosomes enhances proliferation, migration, and tube formation of endothelial cells in in vitro culture models 241,242 . Endothelial cells stimulated with these exosomes have been shown to increase the expression of angiogenesis-related molecules, including FGF, VEGF, VEGFR-2, Ang, E-selectin, CXC motif chemokine 16 (CXCL16), nitric oxide synthase (eNOS) and IL-8.…”

Section: Vascular Precursor Cells In Vascularization During Tissue Inmentioning

confidence: 99%

“…Encountering extracellular vesicles, pericytes increase expression of VEGF 243 , which further promotes the survival and stabilization of endothelial cells. In vivo treatment with EPC-derived exosomes has been reported to accelerate re-endothelialization in the early phase post endothelial damage in the carotid artery in rats 241 and to enhance cutaneous wound healing in diabetic rats 242 . MSCs are known to produce many paracrine factors for neovascularization, including VEGF, IGF-1, TGF-β1, MCP-1, and IL-8 244–247 .…”

Section: Vascular Precursor Cells In Vascularization During Tissue Inmentioning

confidence: 99%

“…Local delivery of marrow-derived EPCs to the site of bone fractures has been reported to enhance VEGF expression and to promote bone healing in experimental animals 272,273 . Development of bioengineered scaffolds modified with vasculogenic mediators and containing stem and progenitor cells may enhance vascularization in large bone grafts 242 . Along this path, a variety of precursor cells, including EPCs, MSCs, HSCs, pericytes, and ESCs, have been tested.…”

Section: Application Of Vascular Precursor Cells In the Treatment Of mentioning

confidence: 99%

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Vascular precursor cells in tissue injury repair

Shi

Zhang

Yin

et al. 2017

Translational Research

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Vascular precursor cells include stem and progenitor cells giving rise to all mature cell types in the wall of blood vessels. Upon tissue injury, local hypoxia and inflammation result in generation of vasculogenic mediators which orchestrate migration of vascular precursor cells from their niche environment to the site of tissue injury. The intricate crosstalk among signaling pathways coordinates vascular precursor cell proliferation and differentiation during neovascularization. Establishment of normal blood perfusion plays an essential role in effective repair of the injured tissue. In recent years, studies on molecular mechanisms underlying the regulation of vascular precursor cell function have achieved substantial progress, which promotes exploration of vascular precursor cell-based approaches to treat chronic wounds and ischemic diseases in vital organ systems. Verification of safety and establishment of specific guidelines for the clinical application of vascular precursor cell-based therapy remain major challenges in the field.

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Human endothelial progenitor cells-derived exosomes accelerate cutaneous wound healing in diabetic rats by promoting endothelial function

Cited by 135 publications

References 27 publications

Extracellular Vesicles in Angiogenesis

Extracellular Vesicles in Angiogenesis

Exosomes as a novel pathway for regulating development and diseases of the skin (Review)

Vascular precursor cells in tissue injury repair

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