Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production.

Abstract

The partial amino acid sequence of the NH2 terminus of a factor named human B-cell differentiation factor or B-cell stimulatory factor 2 (BSF-2) has been determined. Antibodies raised against the synthetic peptide corresponding to residues 1-13 of the NH2-terminal sequence specifically react with BSF-2 generated by a T-cell line and by phytohemagglutinin-stimulated normal T cells. Furthermore, the antipeptide antibodies react with a BSF-2-1ike factor produced by cardiac myxoma as well as uterine cervical carcinoma cells. The results show that BSF-2 functions in vivo as well and suggest that the constitutive production of BSF-2 may be involved in autoantibody production, since patients with cardiac myxoma and uterine carcinoma showed autoantibody production.

Interleukin-6 Production by Macrophages from BALB/c Mice with a Chronic Infection of Lactic Dehydrogenase Virus

“…Moreover, the present results suggest that cyclooxygenase products, especially PGEs, one of the regulators of macrophage function such as Ia antigen expression [5,18], IL-1 production [4], and spreading, adhesion and migration [2], may not affect IL-6 production. In addition, though LDV infection causes suppression of autoimmune diseases [3,5,6,10,16], these phenomena may not be due to, at least in part, impaired macrophage IL-6 production, which is known as an enhancer of autoimmune diseases [1,9] . We could not eliminate the possibility that IL-6 production from other immunocompetent cells especially helper T2 cells [13] might be suppressed, since it has been suggested that defective helper T cell function was reported in chronically LDV-infected mice [11].…”

Co-stimulation of cultured peripheral blood mononuclear cells from intrinsic asthmatics with exogenous recombinant IL-6 produce high levels of IL-4-dependent IgE

“…Interleukin (IL)-6 is a cytokine, with a wide range of biological activities, produced by many different cell types, including tumoral cells [6][7][8][9]. It is involved in the regulation of inflammatory responses [10][11][12][13], and plays a critical role in the modulation of immune responses.…”

Serum Cytokines in Gestational Trophoblastic Diseases

“…IL-6 has been shown to be produced by human tumor cells including cardiac myxoma cells (28) and myeloma cells (29). There is evidence that IL-6 is produced by both human epidermal and epidermoid carcinoma cells lines (30) as well as epithelial tumors including bladder carcinoma (3 1) and renal cell carcinoma (32).…”