The rise of cytokines in amniotic fluid of cases of PROM with infection may represent: (a) enhanced macrophage activity for immunosurveillance of the fetus; (b) a preparatory step for the initiation of labor; and (c) a valuable tests for diagnosing chorioamnioitis. The mechanism responsible for PROM in the presence or absence of infection is likely to be of different nature.
These results demonstrate that fibronectin may be a more valuable biomarker than thrombomodulin and PAI-1 for the assessment of endothelial damage in preeclampsia and eclampsia.
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