Interleukin-6 Production by Macrophages from BALB/c Mice with a Chronic Infection of Lactic Dehydrogenase Virus

Iwata, Hiroyuki; Hayashi, Toshiharu

doi:10.1538/expanim1978.43.4_559

Cited by 1 publication

(1 citation statement)

References 10 publications

(15 reference statements)

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“…Our results indicate that, after LDV infection, a transient production of IL-6 occurred that originated mostly from macrophages rather than from T lymphocytes. It has been suggested previously that LDV does not trigger IL-6 production and therefore that LDV-induced immune alterations could not be related to this cytokine (48). However, this analysis of IL-6 production was performed in chronically infected mice, which can easily account for the difference with our results that showed a rapid decrease of the cytokine expression 2 days after infection.…”

Section: Discussioncontrasting

confidence: 54%

Distinct requirements for IL-6 in polyclonal and specific Ig production induced by microorganisms

Markine-Goriaynoff¹,

Nguyễn²,

Bigaignon³

et al. 2001

International Immunology

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The role of IL-6 in Ig production induced in the mouse by lactate dehydrogenase-elevating virus (LDV), Toxoplasma gondii or lipopolysaccharide (LPS) was assessed. Following infection with LDV, a strong activator of B cells, an early and transient IL-6 production was observed, that originated predominantly from macrophages. Whereas LDV-induced B lymphocyte proliferation appeared independent of IL-6, mice deficient for this cytokine showed a marked reduction in their total T-dependent IgG2a production when compared to their normal counterparts. By contrast, specific responses directed against either LDV or non-viral antigens administered at the time of infection were not decreased in the absence of IL-6. Similarly, polyclonal, but not anti-parasite IgG2a production triggered by T. gondii infection was strongly dependent on the presence of IL-6. Finally, T-independent total IgG3 secretion triggered by LPS was also markedly reduced in IL-6-deficient mice. These results suggest that IL-6 plays a major role in T-dependent and T-independent polyclonal Ig production following B lymphocyte activation by viruses, and parasites, but not in specific antibody responses induced by the same microorganisms.

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Section: Discussioncontrasting

confidence: 54%