Honokiol inhibits the inflammatory reaction during cerebral ischemia reperfusion by suppressing NF-κB activation and cytokine production of glial cells

Zhang, Peng; Liu, Xiaoyan; Zhu, Yuyan; Chen, Shizhong; Zhou, Demin; Wang, Yinye

doi:10.1016/j.neulet.2012.11.052

Cited by 98 publications

(59 citation statements)

References 23 publications

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“…The factor NF-κB (Section 3.1) promotes the transcription of genes involved in pro-inflammatory responses. In macrophages, NF-κB is activated by inflammatory extracellular signals such as LPS, IL-1 and tumor necrosis factor α (TNF-α), and regulates a number of inflammatory genes, inducing further inflammatory mediators, including NO· and cytokines (Zhang et al, 2013). A second major transcription factor, the activator protein 1 (AP-1), an ubiquitous dimeric protein complex composed of Jun and Fos subfamilies (Curran and Franza, 1988), is also activated by many pathophysiological stimuli, including LPS, reactive oxygen species (ROS), mitogenic growth factors, inflammatory cytokines, growth factors of the transforming growth factor-β (TGF-β family, ultraviolet (UV) and ionizing irradiation, cellular stress, antigen binding, and neoplastic transformation.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Poivre

Duez

2017

J. Zhejiang Univ. Sci. B

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Traditional Chinese herbal drugs have been used for thousands of years in Chinese pharmacopoeia. The bark of Magnolia officinalis Rehder & E. Wilson, known under the pinyin name "Houpo", has been traditionally used in Chinese and Japanese medicines for the treatment of anxiety, asthma, depression, gastrointestinal disorders, headache, and more. Moreover, Magnolia bark extract is a major constituent of currently marketed dietary supplements and cosmetic products. Much pharmacological activity has been reported for this herb and its major compounds, notably antioxidant, anti-inflammatory, antibiotic and antispasmodic effects. However, the mechanisms underlying this have not been elucidated and only a very few clinical trials have been published. In vitro and in vivo toxicity studies have also been published and indicate some intriguing features. The present review aims to summarize the literature on M. officinalis bark composition, utilisation, pharmacology, and safety.

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Section: Anti-inflammatory Activitymentioning

confidence: 99%

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Poivre

Duez

2017

J. Zhejiang Univ. Sci. B

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“…1), isolated from the barks of Magnolia officinalis, has the ability to cross the blood-brain barrier (Wang et al, 2011). Pharmacologically, honokiol possesses diverse biological activities, including anxiolytic (Kuribara et al, 1999), analgesic (Lin et al, 2009), antidepressant (Xu et al, 2008), antithrombotic (Hu et al, 2005), antimicrobial (Ho et al, 2001), antispasmodic (Ko et al, 2003), anti-tumorigenic (Fried and Arbiser, 2009), and neuroprotective (Zhang et al, 2013) properties. In addition, honokiol has been found to prevent the age-related memory and learning deficits found in senescence-accelerated (SAMP8) mice through preserving cholinergic neurons and enhancing phosphorylation and activity of Akt (Matsui et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Honokiol improves learning and memory impairments induced by scopolamine in mice

Xian

Mao

et al. 2015

European Journal of Pharmacology

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“…Several studies have reported that honokiol induces cell-cycle arrest and apoptosis in cancer cells67 and inhibits tumor-associated lymphangiogenesis and metastasis in lung carcinoma models induced by vascular endothelial growth factor8. Zhang et al 9. discovered novel evidence for the anti-inflammatory effects of honokiol in the treatment of ischemic stroke by inhibiting NF-κB activation.…”

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confidence: 99%

Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies

Lee

Chang

et al. 2017

Sci Rep

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Honokiol, derived from Magnolia officinalis, has various pharmacological properties. Platelet activation plays a critical role in cardiovascular diseases. Honokiol has been reported to inhibit collagen-stimulated rabbit platelet aggregation. However, detailed further studies on the characteristics and functional activity of honokiol in platelet activation are relatively lacking. In the present study, honokiol specifically inhibited platelet aggregation and Ca+2 ion mobilization stimulated with collagen or convulxin, an agonist of glycoprotein (GP) VI, but not with aggretin, an agonist of integrin α2β1. Honokiol also attenuated the phosphorylation of Lyn, PLCγ2, PKC, MAPKs, and Akt after convulxin stimulation. Honokiol have no cytotoxicity in zebrafish embryos. Honokiol diminished the binding of anti-GP VI (FITC-JAQ1) mAb to human platelets, and it also reduced the coimmunoprecipitation of GP VI-bound Lyn after convulxin stimulation. The surface plasmon resonance results revealed that honokiol binds directly to GP VI, with a KD of 289 μM. Platelet function analysis revealed that honokiol substantially prolonged the closure time in human whole blood and increased the occlusion time of thrombotic platelet plug formation in mice. In conclusion, honokiol acts as a potent antagonist of collagen GP VI in human platelets, and it has therapeutic potential in the prevention of the pathological thrombosis.

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Honokiol inhibits the inflammatory reaction during cerebral ischemia reperfusion by suppressing NF-κB activation and cytokine production of glial cells

Cited by 98 publications

References 23 publications

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Honokiol improves learning and memory impairments induced by scopolamine in mice

Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies

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