Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder &amp; E. Wilson (Houpo) and its constituents

Poivre, Mélanie; Duez, Pierre

doi:10.1631/jzus.b1600299

Cited by 106 publications

(79 citation statements)

References 126 publications

(165 reference statements)

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“…Magnolol, a multifunctional component derived from Chinese herb Magnolia officinalis, has been shown to possess anti-viral, anti-inflammatory, anti-microbial, cardiovascular and neuroprotective effects (12,13). Magnolol-induced apoptosis in different types of cancer cells, including lung, colon, and prostate cancer cells was also presented (14).…”

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confidence: 99%

Magnolol Induces Apoptosis and Inhibits ERK-modulated Metastatic Potential in Hepatocellular Carcinoma Cells

Kuan

Chen

et al. 2018

In Vivo

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Background/Aim: The aim of the present study was to evaluate the anti-cancer effect of magnolol in hepatocellular carcinoma (HCC) cells in vitro. Materials and Methods: HCC SK-Hep1 cells were treated with different concentrations of magnolol or PD98059 [extracellular-signal-regulated kinase (ERK) inhibitor] for 48 h, and then cell viability, apoptosis, signal transduction, expression of anti-apoptotic and metastasis-related proteins, and cell invasion were investigated by [3][4]-2,5-diphenyltetrazolium bromide] (MTT) assay, flow cytometry, nuclear factor kappa B (NF-ĸB) reporter gene, western blotting, and cell invasion assays. Results: Magnolol significantly induced accumulation of sub-G 1 phase and caspase-3 activation and inhibited NF-ĸB activation, cell invasion, expression of phosphorylated ERK (pERK), anti-apoptotic and metastatic-related proteins. ERK inactivation was required for magnolol-induced inhibition of metastatic potential of SK-Hep1 cells. Conclusion: Taken together, these results indicated that magnolol not only induced apoptosis, but also inhibited ERK-modulated metastatic potential of HCC SK-Hep1 cells.

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confidence: 99%

Magnolol Induces Apoptosis and Inhibits ERK-modulated Metastatic Potential in Hepatocellular Carcinoma Cells

Kuan

Chen

et al. 2018

In Vivo

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“…The scientific rationale for the clinical use of honokiol in the treatment of Alzheimer's disease through attenuated amyloid β‐induced cell death has also been reported (Hoi, Ho, Baum, & Chow, ). Research indicates that the anxiolytic activity of magnolia is related to neurotransmitters, serotonin, and dopamine (Poivre & Duez, ). Briefly, honokiol and magnolol were able to normalize the biochemical abnormalities in brain serotonin via up‐regulating the cyclic adenosine monophosphate pathway (Lee et al, ).…”

Section: Discussionmentioning

confidence: 99%

A randomized controlled pilot study of the effectiveness of magnolia tea on alleviating depression in postnatal women

Xue

Zhang

Shen

et al. 2020

Food Science & Nutrition

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The magnolia tea has been used in traditional oriental medicine for multiple purposes including sleep aid. Postpartum depression is a mental illness that adversely affects the health and well‐being of many families with newborns. Given the known effectiveness and relative safety, herein we aimed to investigate whether magnolia tea has a palliative effect on postpartum depression. The qualified participants were randomly assigned to the intervention group or the control group. The participants in the intervention group drunk magnolia tea, while the control group received regular postpartum care only. The outcome variables including Postpartum Sleep Quality Scale (PSQS), Edinburgh Postnatal Depression Scale (EPDS), and Postpartum Fatigue Scale (PFS) were assessed and compared. In comparison with the control group, the intervention group demonstrated significant difference for physical‐symptom‐related sleep inefficiency (PSQS Factor 2) at 3 weeks post‐test (t = −2.10, p = .03). The comparison results also revealed significant differences for PFS at both 3 weeks post‐test (t = −2.02, p = .04) and 6 weeks post‐test (t = −1.99, p = .04). Further, magnolia tea intervention significantly alleviated the symptoms of depression, reflected by the EPDS scores at 3 weeks post‐test (t = −2.38, p = .02) and 6 weeks post‐test (t = −2.13, p = .02). Our trial results suggested that drinking single‐ingredient magnolia tea for a 3‐week duration has positive effects on postpartum women. Magnolia tea is recommended as a supplementary approach to ameliorate sleep quality of postpartum women, while alleviating their symptoms of depression.

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“…The magnolia plant contains a variety of chemical compounds with demonstrated bioactive properties, and both the bark and flower buds of Magnolia officinalis have been used for hundreds of years in traditional human medicine (8). Magnolia extracts and its purified components have been demonstrated to have anti-cancer effects, as well as for treating a variety of neuronal, inflammatory, cardiovascular, and gastrointestinal disorders (8)(9)(10)(11). Few studies, however, have investigated the medicinal effects of magnolia in veterinary medicine (12).…”

Section: Introductionmentioning

confidence: 99%

Dietary Supplementation With Magnolia Bark Extract Alters Chicken Intestinal Metabolite Levels

Park

Lillehoj

et al. 2020

Front. Vet. Sci.

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Magnolia bark extract administered as a dietary supplement to poultry confers a performance and health benefit, but the mechanisms are unknown. Here, a metabolomics approach was used to identify changes in intestinal metabolite levels in chickens fed an unsupplemented diet or a diet supplemented with magnolia bark extract. Total body weight gains of chickens fed magnolia bark-supplemented diets were increased 2% (from 861 to 878 g/chicken), compared with chickens fed an unsupplemented diet. Compared with unsupplemented controls, the levels of 278 intestinal biochemicals (metabolites) were altered (165 increased, 113 decreased) in chickens given the magnolia-supplemented diet. Data for biochemicals of intestinal contents of chickens fed the unsupplemented diet clustered on the left side of the PCA score plot, while those of the magnolia-supplemented diet were separated and clustered on the right side. The biochemicals included changes in the levels of amino acids, fatty acids, peptides, and nucleosides, which provided a distinctive biochemical signature unique to the magnolia-supplemented group, compared with the unsupplemented group. These results provide the foundation for future studies to identify naturally-produced biochemicals that might be used to improve poultry growth performance.

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Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Cited by 106 publications

References 126 publications

Magnolol Induces Apoptosis and Inhibits ERK-modulated Metastatic Potential in Hepatocellular Carcinoma Cells

Magnolol Induces Apoptosis and Inhibits ERK-modulated Metastatic Potential in Hepatocellular Carcinoma Cells

A randomized controlled pilot study of the effectiveness of magnolia tea on alleviating depression in postnatal women

Dietary Supplementation With Magnolia Bark Extract Alters Chicken Intestinal Metabolite Levels

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