Honokiol improves learning and memory impairments induced by scopolamine in mice

Xian, Yan‐Fang; Ip, Siu‐Po; Mao, Qing-Qiu; Su, Zi‐Ren; Chen, Jiannan; Lai, Xiaoping; Lin, Zhi‐Xiu

doi:10.1016/j.ejphar.2015.04.013

Cited by 45 publications

(39 citation statements)

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“…Neurodegenerative diseases such as AD are characterized by elevated ChEs activities which result in impaired cholinergic neurotransmission as a result of excessive hydrolysis of acetylcholine (Klafki et al., ; Nwanna et al., ). Previous findings have shown that SCOP can induce an elevation in rats’ AChE activity, thereby mimicking the pathophysiology of many neurodegenerative diseases (Gutierres et al., ; Xian et al., ). The ability of dietary inclusions of AE and BN leaves to reverse the SCOP‐induced elevation in ChEs activities in experimental rats could be as a result of their constituent phytochemicals.…”

Section: Discussionmentioning

confidence: 83%

“…In addition, as reported in Figure 7a , 2016). Previous findings have shown that SCOP can induce an elevation in rats' AChE activity, thereby mimicking the pathophysiology of many neurodegenerative diseases (Gutierres et al, 2010;Xian et al, 2015). The ability of dietary inclusions of AE and BN leaves to reverse the SCOP-induced elevation in ChEs activities in experimental rats could be as a result of their constituent phytochemicals.…”

Section: Re Sultmentioning

confidence: 89%

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Green leafy vegetables from two Solanum spp. (Solanum nigrum L and Solanum macrocarpon L) ameliorate scopolamine‐induced cognitive and neurochemical impairments in rats

Ogunsuyi

Ademiluyi

Oboh

et al. 2018

Food Science & Nutrition

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This study examined the modulatory effect of Black nightshade (Solanum nigrum L) and African eggplant (Solanum macrocarpon L) leaves on cognitive function, antioxidant status, and activities of critical enzymes of monoaminergic and cholinergic systems of neurotransmission in scopolamine‐administered rats. Cognitive impairment was induced in albino rats pretreated with dietary inclusions of Black nightshade (BN) and African eggplant (AE) leaves by single administration (i.p.) of scopolamine (2 mg/kg body weight). Prior to termination of the experiment, the rats were subjected to spontaneous alternation (Y‐maze) test to assess their spatial working memory. Thereafter, activities of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidase (MAO), arginase, and antioxidant enzymes (catalase, SOD, and GST) of rat brain homogenate were determined. Also, the malondialdehyde (MDA), nitrite, and GSH contents of the homogenate were determined. The results showed that pretreatment with dietary inclusions of AE and BN significantly reversed the impairment in the rats’ spatial working memory induced by scopolamine. Similarly, elevations in activities of AChE, BChE, and MAO induced by scopolamine were significantly reversed in rats pretreated with dietary inclusions of AE and BN. In addition, impaired antioxidant status induced by scopolamine was reversed by pretreatment with dietary inclusions of AE and BN. This study has shown that dietary inclusions of AE and BN could protect against cognitive and neurochemical impairments induced by scopolamine, and hence, these vegetables could be used as a source of functional foods and nutraceuticals for the prevention and management of cognitive impairments associated diseases such as Alzheimer's disease.

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Section: Discussionmentioning

confidence: 83%

Section: Re Sultmentioning

confidence: 89%

Green leafy vegetables from two Solanum spp. (Solanum nigrum L and Solanum macrocarpon L) ameliorate scopolamine‐induced cognitive and neurochemical impairments in rats

Ogunsuyi

Ademiluyi

Oboh

et al. 2018

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

“…Since cholinergic transmission is stopped mostly by acetylcholine hydrolysis via AChE activity in the synaptic cleft, but excessive AChE activity cause the continuous acetylcholine deficiency and memory deficits (Xian et al, ). Thus, inhibition of AChE activity may be an important strategy for managing AD (Anand, Singh, & Singh, ).…”

Section: Discussionmentioning

confidence: 99%

Memory‐enhancing effects ofIshige foliaceaextract: In vitro and in vivo study

et al. 2020

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Ishige foliacea is used as a functional food in East‐Asian countries. We evaluated the memory‐enhancing effect of an ethanol extract of I. foliacea (EEI) using in vitro and in vivo models. In vitro acetylcholinesterase and β‐secretase inhibitory activities, antioxidant properties, and neuroprotective effects against human neuronal cell death by H2O2 and β‐amyloid (Aβ) were investigated. We explored the memory‐enhancing effect and its underlying mechanism in a mouse model of scopolamine (SCO)‐induced memory deficits. EEI showed free radical scavenging and acetylcholinesterase and β‐secretase inhibition activities. Additionally, EEI significantly decreased neuronal cell death induced by H2O2 or Aβ in human neuroblastoma SH‐SY5Y cells. In behavior tests, SCO‐induced memory deficits was improved by EEI administration. EEI increased the protein expression of brain‐derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) and phosphorylated extracellular signal‐regulated kinase, which are related to synaptic plasticity in the hippocampus. EEI may ameliorate memory deficits and prevent neurodegenerative disorders. Practical applications As the population ages, dementia, a neurodegenerative disease, is becoming an important problem. Various Alzheimer's drugs have been developed based on the disease mechanism, but alternative treatments are required because of the low bioavailability and hepatotoxicity of current medications. Ishige foliacea is a type of brown algae containing various bioactive substances. Phlorotannins, known as brown algae polyphenols, have been studied for their various functionalities such as, anticancer, anti‐obesity, antioxidant, and sleep improvement effects, and have attracted attention as raw materials for developing new natural products. We found that the EEI mitigates SCO‐induced damage by protecting neurons from oxidative stress‐induced cell damage, controlling synthesis mechanisms of the causative agents of AD, and activating BDNF–TrkB–ERK signaling to promote memory function in the hippocampus. The results of this study can serve as a foundation for further research. Additionally, I. foliacea may be useful for treating and improving AD.

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“…As a potent reactive oxygen species (ROS) scavenger, it is also reported that HNK can enhance the overexpression of SIRT3 to improve antioxidant activity and mitochondrial energy regulation thereby reducing the levels of Aβ and sAPPβ in Chinese Hamster Ovarian (CHO) cells . Additionally, Xian et al suggested that HNK could improve learning and memory impairments induced by scopolamine in mice and attenuate the concentration of prostaglandin E2 and cyclooxygenase‐2 level and the neuroinflammatory processes …”

Section: Introductionmentioning

confidence: 99%

SIRT3 activator honokiol ameliorates surgery/anesthesia‐induced cognitive decline in mice through anti‐oxidative stress and anti‐inflammatory in hippocampus

Chen

et al. 2018

CNS Neurosci Ther

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Aims Increasing evidence indicates that neuroinflammatory and oxidative stress play two pivotal roles in cognitive impairment after surgery. Honokiol (HNK), as an activator of Sirtuin3 (SIRT3), has potential multiple biological functions. The aim of these experiments is to evaluate the effects of HNK on surgery/anesthesia‐induced cognitive decline in mice. Methods Adult C57BL/6 mice received a laparotomy under sevoflurane anesthesia and HNK or SIRT3 inhibitor (3‐TYP) treatment. Cognitive function and locomotor activity of mice were evaluated using fear conditioning test and open field test on postoperative 1 and 3 days. Neuronal apoptosis in CA1 and CA3 area of hippocampus was examined using TUNEL assay. And Western blot was applied to measure the expression of pro‐inflammatory cytokines and SIRT3/SOD2 signaling‐associated proteins in hippocampus. Meanwhile, SIRT3 positive cells were calculated by immunohistochemistry. The mitochondrial membrane potential, malondialdehyde (MDA), and mitochondrial radical oxygen species (mtROS) were detected using standard methods. Results Honokiol attenuated surgery‐induced memory loss and neuronal apoptosis, decreased neuroinflammatory response, and ameliorated oxidative damage in hippocampus. Notably, surgery/anesthesia induced an obviously decrease in hippocampal SIRT3 expression, whereas the HNK increased SIRT3 expression and thus decreased the acetylation of superoxide dismutase 2 (SOD2). However, 3‐TYP treatment inhibited the HNK's rescuing effects. Conclusions These results suggested that activation of SIRT3 by honokiol may attenuate surgery/anesthesia‐induced cognitive impairment in mice through regulation of oxidative stress and neuroinflammatory in hippocampus.

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Honokiol improves learning and memory impairments induced by scopolamine in mice

Cited by 45 publications

References 46 publications

Green leafy vegetables from two Solanum spp. (Solanum nigrum L and Solanum macrocarpon L) ameliorate scopolamine‐induced cognitive and neurochemical impairments in rats

Green leafy vegetables from two Solanum spp. (Solanum nigrum L and Solanum macrocarpon L) ameliorate scopolamine‐induced cognitive and neurochemical impairments in rats

Memory‐enhancing effects ofIshige foliaceaextract: In vitro and in vivo study

SIRT3 activator honokiol ameliorates surgery/anesthesia‐induced cognitive decline in mice through anti‐oxidative stress and anti‐inflammatory in hippocampus

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