Green leafy vegetables from two Solanum spp. (<i>Solanum nigrum</i> L and <i>Solanum macrocarpon</i> L) ameliorate scopolamine‐induced cognitive and neurochemical impairments in rats

Ogunsuyi, Opeyemi B.; Ademiluyi, Adedayo O.; Oboh, Ganiyu; Oyeleye, Sunday I.; Dada, Felix Abayomi

doi:10.1002/fsn3.628

Cited by 32 publications

(32 citation statements)

References 59 publications

(105 reference statements)

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“…A very interesting study has shown that dietary inclusions of Solanum leaf could protect against cognitive and neurochemical impairments induced by scopolamine, and, hence, this vegetable could be used as a source of functional foods and nutraceuticals for the prevention and management of cognitive impairment-associated diseases such as Alzheimer’s disease [21].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activities of Solanum Nigrum L. Leaf Extracts Determined in in vitro Cellular Models

Campisi

Acquaviva

Raciti

et al. 2019

Foods

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Several medicinal foods abound in traditional medicine with antioxidant potentials that could be of importance for the management of several diseases but with little or no scientific justification to substantiate their use. Thus, the objective of this study was the assessment of the antioxidant effect of two leave extracts of Solanum nigrum L. (SN), which is a medicinal plant member of the Solanaceae family, mainly used for soup preparation in different parts of the world. Then methanolic/water (80:20) (SN1) and water (SN2) leaves extracts were prepared. The total polyphenolic content and the concentration of phenolic acids and flavones compounds were determined. In order to verify whether examined extracts were able to restore the oxidative status, modified by glutamate in primary cultures of astrocytes, the study evaluated the glutathione levels, the intracellular oxidative stress, and the cytotoxicity of SN1 and SN2 extracts. Both extracts were able to quench the radical in an in vitro free cellular system and restore the oxidative status in in vitro primary cultures of rat astroglial cells exposed to glutamate. These extracts prevented the increase in glutamate uptake and inhibited glutamate excitotoxicity, which leads to cell damage and shows a notable antioxidant property.

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Section: Introductionmentioning

confidence: 99%

Antioxidant Activities of Solanum Nigrum L. Leaf Extracts Determined in in vitro Cellular Models

Campisi

Acquaviva

Raciti

et al. 2019

Foods

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“…African nightshade (Solanum nigrum L.) yang di Indonesia dikenal dengan nama leunca atau ranti, pada saat ini popularitasnya meningkat sebagai sayuran daun maupun buah (Putriantari & Santosa 2014;Santosa et al 2015). Di Afrika, leunca telah diteliti sebagai sayuran fungsional multiguna karena mudah dibudidayakan dan mengandung nutrisi tinggi, yaitu vitamin A, vitamin C, dan zat antioksidan (Smith & Eyzaguirre 2007;Loganayaki et al 2010;Uusiku et al 2010;Janet et al 2016;Onyango et al 2016;Ogunsuyi et al 2018).…”

Section: Pendahuluanunclassified

Shoots and Fruits Harvesting of Solanum nigrum L. Treated with Different Nitrogen Levels

Yulianti

Santosa²,

Susila

2020

JIPI

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ABSTRAKPeningkatan popularitas pucuk dan buah leunca sebagai sayuran di Indonesia mendorong petani memanen keduanya secara bergantian pada tanaman yang sama dan tingkat hasil diduga dipengaruhi oleh dosis pupuk, khususnya nitrogen. Penelitian ini bertujuan untuk mengetahui dosis pupuk nitrogen terbaik pada tanaman leunca yang dipanen pucuk dan buah dalam satu tanaman. Bibit leunca ditanam di Kebun Percobaan Leuwikopo IPB dengan lima dosis N, yakni 0, 90, 180, 270, dan 360 kg/ha. Hasil menunjukkan bahwa panen pucuk dan buah leunca sensitif terhadap dosis nitrogen. Pada dosis N rendah, hasil panen buah lebih tinggi dibandingkan dengan panen daun, sedangkan pada dosis N tinggi hasil panen daun lebih tinggi dibandingkan dengan hasil panen buah. Hubungan panen daun dan buah dengan dosis N menunjukkan pola kuadratik, yakni r 2 =0,9671 dan r 2 =0,9483 dengan dosis N optimum untuk produksi daun sebesar 304,8 kg/ha dan produksi buah sebesar 336,5 kg/ha. Ketepatan dosis N pada tanaman leunca penting karena status kandungan nitrat daun mengikuti pola positif kuadratik (r 2 =0,5264) dan linear pada buah (r 2 =0,9587) dengan peningkatan dosis dari sebesar 90 menjadi 360 kg N/ha. Dari nilai akumulasi bobot total panen pucuk (3 kali panen) dan buah (4 kali panen), dosis N terbaik panen pucuk dan buah leunca dapat dilakukan pada tanaman yang sama sebesar 271,1 kg/ha (r 2 =0,9644). Kata kunci: laju fotosintesis, ranti, serapan N, status nitrat, tumpang sari ABSTRACT The increasing popularity of leaf and fruit of African nightshade as vegetables in Indonesia stimulates farmers to harvest both leaf and fruit from single plant alternately; the yield is presumably affected by fertilizer rate, e.g., nitrogen. The present study aimed to evaluate such hypothesis through evaluation of plant production, N absorption, and its status. Seedlings were treated with five N levels, i.e., 0, 90, 180, 270, and 360 kg/ha in Leuwikopo Experimental Farm, IPB Bogor, Indonesia. The results revealed that leaf and fruit productions were sensitive to nitrogen level. Leaf and fruit productions had quadratic correlation to N levels, i.e., r 2 =0.9671 and r 2 =0.9483 with optimum dosages as 304.8 kg/ha and 336.5 kg/ha, respectively. Proper N application is important for both leaf and fruit productions because nitrate level in leaf had quadratic relationship (r 2 =0.5264) and it has a linear relationship in fruit production (r 2 =0.9587) by increasing N level from 90 to 360 kg N/ha. From the total fresh mass leaves and fruits harvested, the optimum N for the best alternate harvesting was 271.1 kg/ha (r 2 =0.9644).

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“…A portion of the blended sample was subsequently cooked (steamed) for 30 min in a stainless pot on an electric cooker at 100 ± 0.5°C, and designated as "cooked samples" while the other portion was designated as "raw samples." Both raw and cooked portions of the pepper samples were lyophilized and were subsequently used to formulate diet for the experimental animals (Ogunsuyi et al, 2018).…”

Section: Sample Collection and Preparationmentioning

confidence: 99%

“…i.p) 30 min to the termination of the experiment as reported previously by Akinyemi et al (2017). Group III serves as the positive control and were administered 5 mg/kg body weight (p.o) of donepezil hydrochloride (Ogunsuyi et al, 2018) once before administration of scopolamine.…”

Section: Experimental Designmentioning

confidence: 99%

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Influence of cooking on the neuroprotective properties of pepper (bird pepper and cayenne pepper) varieties in scopolamine‐induced neurotoxicity in rats

Ademiluyi

Oyesomi

Ogunsuyi

et al. 2020

J. Food Process. Preserv.

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Neurodegenerative diseases such as Alzheimer's disease (AD) are often characterized by multifactorial clinical features such as loss of memory function, protein aggregation, progressive loss of neurons, cognitive impairment, neuronal cell dysfunction and/or death (Adefegha et al., 2016). AD, the leading cause of dementia is characterized by impairments in neurotransmission systems, including the cholinergic, purinergic, and monoaminergic systems. Acetylcholine (ACh) is key to the cholinergic arrangement of neurotransmission. ACh is enzymatically broken down by cholinesterases (ChEs). Acetylcholinesterase (AChE) degrades the neurotransmitter ACh and subsequently reduces the ACh level in the brain (Changeux, 2010). AChE inhibitors can increase ACh level in cholinergic synapses, which have shown promise in the alleviation of neurodegenerative diseases. To this end, many studies have

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Green leafy vegetables from two Solanum spp. (Solanum nigrum L and Solanum macrocarpon L) ameliorate scopolamine‐induced cognitive and neurochemical impairments in rats

Cited by 32 publications

References 59 publications

Antioxidant Activities of Solanum Nigrum L. Leaf Extracts Determined in in vitro Cellular Models

Antioxidant Activities of Solanum Nigrum L. Leaf Extracts Determined in in vitro Cellular Models

Shoots and Fruits Harvesting of Solanum nigrum L. Treated with Different Nitrogen Levels

Influence of cooking on the neuroprotective properties of pepper (bird pepper and cayenne pepper) varieties in scopolamine‐induced neurotoxicity in rats

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