Homocysteine and other cardiovascular risk factors in patients with lichen planus

Saleh, Noha A.; Samir, N.; Megahed, H.; Farid, Erini

doi:10.1111/jdv.12329

Cited by 35 publications

(46 citation statements)

References 36 publications

(35 reference statements)

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“…In addition to MS, which significantly increases the risk of cardiovascular events in LP patients, we found that there are additional risk factors such as higher BMI, increased prevalence of frank hypertension, and frank DM. Other researchers have reported higher levels of serum homocysteine, fibrinogen, and CRP in LP as risk factors for the hypercoagulable state, cardiovascular events, and atherosclerosis (19). Interestingly, electrocardiographic changes such as P-wave dispersion has been observed in LP patients as an independent risk factor for cardiac involvement and atrial fibrillation (4).…”

Section: Discussionmentioning

confidence: 99%

“…However, there is much research available that denies the above-mentioned association (11)(12)(13). Recent evidence suggests that LP can be associated with dyslipidemia and other components of MS (14)(15)(16)(17)(18)(19)(20)(21). The early investigation and diagnosis of MS in this population of patients will help control the risk factors and prevent the serious morbidity and mortality of cardiovascular events.…”

Section: Introductionmentioning

confidence: 99%

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The Association of Cutaneous Lichen Planus and Metabolic Syndrome: A Case-Control Study

et al. 2016

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Background: Previous research declares that metabolic syndrome (MS) is a cluster of risk factors that contribute to a significant level of incidence of cardiovascular diseases and diabetes mellitus. Lichen Planus (LP) is a potential factor to affect dyslipidemia and other components of MS. Objectives: The aim of this research was to assess the association of MS, dyslipidemia, weight, hypertension, and diabetes mellitus with cutaneous LP. Methods: To reach the goal of this research, a case-control study was designed. The study sample included 140 participants dividing into two groups of 70. The first group was selected from cutaneous LP patients while the second group was selected randomly. The groups were matched in terms of age and gender. Results:The results of this research demonstrated that MS was present in 41 (58.6%) LP patients vs. 12 (17.1%) controls. (OR: 6.83; P value < 0.001). All metabolic syndrome criteria were significantly common among LP patients except for decreased high density of lipoprotein level. Dyslipidemia was observed in 57 (81.42%) patients vs. 25 (31.7%) controls (OR: 7.8; P value < 0.001). No statistically significant association was found between gender, the concomitant involvement of oral mucosa, hair, or nail and MS. Conclusions: Based on the results of this research, it can be concluded that cutaneous LP is in association with a significant level of risk for metabolic syndrome, dyslipidemia, diabetes mellitus, and hypertension. It can also be concluded that the investigation of cardiovascular risk factors in these patients and focusing on the modification of their lifestyle and comorbidities are the other essential issues.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Association of Cutaneous Lichen Planus and Metabolic Syndrome: A Case-Control Study

et al. 2016

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“…Moreover, knowledge on cardiovascular risk factors in patients with LP is very limited. Only two recent studies have reported increased cardiovascular risk in patients with LP, with some conflicting data [13,14].…”

Section: Introductionmentioning

confidence: 96%

Prevalence of Metabolic Syndrome in Patients with Mucosal Lichen Planus: A Case–Control Study

et al. 2015

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“…Chronic inflammation plays a crucial role in the development of cardiovascular risk factors. In LP, it is known that metabolic and cardiovascular risk factors can be seen more frequently due to chronic inflammation [4]. …”

Section: Introductionmentioning

confidence: 99%

Evaluation of Cardiovascular Risk Factors, Haematological and Biochemical Parameters, and Serum Endocan Levels in Patients with Lichen Planus

Özlü

Karadağ²,

Toprak³

et al. 2016

Dermatology

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Background and Objective: The current study aimed to evaluate cardiovascular risk factors, haematological and biochemical parameters, and serum endocan concentrations in lichen planus (LP) patients. Methods: This study was conducted with 86 cases, including 43 LP patients and 43 healthy controls. Cardiovascular risk factors, haematological and biochemical parameters, and endocan levels were evaluated. Results: The serum endocan concentrations of LP patients were not significantly different from those of the healthy controls (p > 0.05). There were no significant differences in the serum endocan levels according to classification by cardiovascular risk factors and smoking history (p > 0.05). In the LP group, white blood cell count, platelet distribution width and monocyte count/high-density lipoprotein cholesterol ratios were significantly higher when compared to the healthy controls (p < 0.05). The LP group had a lower mean platelet volume than the healthy controls (p < 0.05). Conclusions: Serum endocan levels did not change significantly in patients with LP, and there were significant differences in haematological and biochemical parameters.

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Homocysteine and other cardiovascular risk factors in patients with lichen planus

Abstract: In the present work, patients with lichen planus were found to have higher makers of both metabolic and cardiovascular risk factors in relation to controls most probably due to long standing inflammation.

Cited by 35 publications

References 36 publications

The Association of Cutaneous Lichen Planus and Metabolic Syndrome: A Case-Control Study

The Association of Cutaneous Lichen Planus and Metabolic Syndrome: A Case-Control Study

Prevalence of Metabolic Syndrome in Patients with Mucosal Lichen Planus: A Case–Control Study

Evaluation of Cardiovascular Risk Factors, Haematological and Biochemical Parameters, and Serum Endocan Levels in Patients with Lichen Planus

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