Evaluation of Cardiovascular Risk Factors, Haematological and Biochemical Parameters, and Serum Endocan Levels in Patients with Lichen Planus

Özlü, Emin; Karadağ, Ayşe Serap; Toprak, Aybala Erek; Uzunçakmak, Tuğba Kevser; Gerin, Fethullah; Aksu, Feyza; Özakpınar, Özlem Bingöl; Akdeniz, Necmettın

doi:10.1159/000447587

Cited by 14 publications

(14 citation statements)

References 30 publications

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“…On the other hand, there is another report describing that serum endocan levels in patients with psoriasis vulgaris are comparable with those in healthy controls . In addition, also in lichen planus, endocan levels are not increased in the sera . Thus, it is not still determined whether endocan is associated with development of inflammatory skin diseases.…”

Section: Introductionmentioning

confidence: 94%

Increased endocan expression in lesional skin and decreased endocan expression in sera in atopic dermatitis

Suzuki

Miyagaki

Otobe

et al. 2017

The Journal of Dermatology

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Endocan is a novel human endothelial cell-specific molecule and is mainly expressed in endothelial cells in various tissues. Endocan has the capacity to inhibit leukocytes binding to the vascular endothelium. It also can promote the angiogenesis alongside vascular endothelial growth factor A. Through these functions, endocan has been implicated in the pathogenesis of various inflammatory diseases. To investigate the possible roles of endocan in atopic dermatitis (AD), we examined endocan expression in lesional skin and sera in patients with AD. Endocan mRNA and protein levels were increased in lesional skin of AD compared with healthy skin and endocan was expressed on epidermal keratinocytes and dermal endothelial cells. On the other hand, serum endocan levels in patients with AD were significantly lower than those in healthy controls. Our results suggest that elevated endocan expression in lesional skin may be associated with development of AD through angiogenesis and that decreased endocan expression in sera may be associated with increased leukocyte recruitment in AD.

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Section: Introductionmentioning

confidence: 94%

Increased endocan expression in lesional skin and decreased endocan expression in sera in atopic dermatitis

Suzuki

Miyagaki

Otobe

et al. 2017

The Journal of Dermatology

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“…with lichen planus when compared with the control group. 28 Belli et al 29 compared CBC parameters and MHR ratios in rosacea and control group. NLR ratio was found to be higher in rosacea patients when compared with the control group and they reported that MHR ratios were significantly higher in rosacea patients who also had metabolic syndrome and insulin resistance.…”

Section: Ta B L E 1 Distribution Of Patient and Control Groups By Gendermentioning

confidence: 99%

Investigation of monocyte HDL ratio as an indicator of inflammation and complete blood count parameters in patients with acne vulgaris

2020

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Acne vulgaris is a common inflammatory skin disease that affects the pilosebaceous unit. 1 Acne vulgaris affects 9.4% of the world population. It is most common among young people. It is more common among men; however, its prevalence increases with age in women. In male patients, the probability of severe acne is higher when compared with female patients. 2 Increased sebum production, hyperkeratosis in follicular infundibulum, inflammation and Propionibacterium acne (P acne) are among aetiological factors. Acne vulgaris lesions are first seen on the face and thus can affect patients' quality of life negatively. It has been claimed that acne can cause psychological diseases such as anxiety, low self-worth and depression among adolescents and adults. 1 Although its definite pathogenesis is not clear, immune response and inflammatory lesions caused by the P acne infection are considered as important factors. 3,4 Complete blood count is an analytical test with low cost and it is performed with automatic counting devices and it is used routinely. Complete blood count (CBC) parameters are used as diagnosis biomarkers for many diseases related with inflammatory processes.

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“…In a study, Kim et al [15] found higher PDW and MPV values in patients with psoriasis, a chronic inflammatory skin disease like DLE. In another study with lichen planus, Özlü et al [16] found higher PDW levels and lower MPV levels in the patient group when compared to a control group. Studies with SLE showed lower MPV values and higher PDW values in patients and a positive relationship between PDW and disease activity [17,18].…”

Section: Resultsmentioning

confidence: 90%

Mean platelet volume and platelet distribution width levels in discoid lupus erythematosus patients: A case-control study

İslamoğlu¹,

Demirbaş²

2019

Journal of Surgery and Medicine

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This is an open access article distributed under the terms of the CreativeCommons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND 4.0) where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. AbstractAim: Platelets (PLT) play an important role in inflammatory reactions and immune responses. This study aims to evaluate PLT and PLT parameters in patients with discoid lupus erythematosus (DLE), which is characterized by inflammation. Methods: In this case-control study, a total of 125 participants, consisting of 60 DLE patients and 65 healthy controls, were selected to participate. PLT, platelet distribution width (PDW), mean platelet volume (MPV), plateletcrit (PCT), the ratio of neutrophils to lymphocytes (NLR) and the ratio of platelets to lymphocytes (PLR) were studied retrospectively in both groups. Results: The mean age of the patient group was 47.30 (15.14) years, and the mean age of the control group was 38.08 (13.33) years. There were no statistically significant differences between the PLT, PDW, MPV, PCT, NLR and PLR levels in DLE patients and healthy controls (P=0. 365, P=0.988, P=0.160, P=0.851, P=0.898 and P=0.887, respectively). Conclusion: To the best of our knowledge, there are no reports on PLT, PDW, PCT, NLR, PLR and MPV in patients with DLE. We did not find a significant difference in the DLE group. PLT parameters are low-cost tests that can be used to define inflammation levels in inflammatory diseases. Further prospective studies on this subject will contribute to this work.

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Evaluation of Cardiovascular Risk Factors, Haematological and Biochemical Parameters, and Serum Endocan Levels in Patients with Lichen Planus

Cited by 14 publications

References 30 publications

Increased endocan expression in lesional skin and decreased endocan expression in sera in atopic dermatitis

Increased endocan expression in lesional skin and decreased endocan expression in sera in atopic dermatitis

Investigation of monocyte HDL ratio as an indicator of inflammation and complete blood count parameters in patients with acne vulgaris

Mean platelet volume and platelet distribution width levels in discoid lupus erythematosus patients: A case-control study

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