The Association of Cutaneous Lichen Planus and Metabolic Syndrome: A Case-Control Study

Abstract

Background: Previous research declares that metabolic syndrome (MS) is a cluster of risk factors that contribute to a significant level of incidence of cardiovascular diseases and diabetes mellitus. Lichen Planus (LP) is a potential factor to affect dyslipidemia and other components of MS. Objectives: The aim of this research was to assess the association of MS, dyslipidemia, weight, hypertension, and diabetes mellitus with cutaneous LP. Methods: To reach the goal of this research, a case-control study was designed. The study sample included 140 participants dividing into two groups of 70. The first group was selected from cutaneous LP patients while the second group was selected randomly. The groups were matched in terms of age and gender. Results:The results of this research demonstrated that MS was present in 41 (58.6%) LP patients vs. 12 (17.1%) controls. (OR: 6.83; P value < 0.001). All metabolic syndrome criteria were significantly common among LP patients except for decreased high density of lipoprotein level. Dyslipidemia was observed in 57 (81.42%) patients vs. 25 (31.7%) controls (OR: 7.8; P value < 0.001). No statistically significant association was found between gender, the concomitant involvement of oral mucosa, hair, or nail and MS. Conclusions: Based on the results of this research, it can be concluded that cutaneous LP is in association with a significant level of risk for metabolic syndrome, dyslipidemia, diabetes mellitus, and hypertension. It can also be concluded that the investigation of cardiovascular risk factors in these patients and focusing on the modification of their lifestyle and comorbidities are the other essential issues.

Study of Expression of Suppressor of Cytokine Signaling 3 in Lichen Planus

“…Egyptian Journal of Medical Research (EJMR), Volume 1, Issue2, 2020 As regard smoking, our results agree with Cassol-Spanemberg et al [9] who found that (73.4%) of patients were non-smokers; (26.6 %) of patients smoked, also Sadr Eshkevari et al [10] found that only (37.1%) of the participants were smokers.…”

Lichen sclerosus in female patients is associated with an increased risk of metabolic syndrome and cardiovascular comorbidities: a retrospective cohort review

“…The pathogenesis of LS has been linked to increased oxidative damage and has been associated with autoimmune disorders and genetic factors, although how these contribute to systemic inflammation is not wholly understood 4,5 . We postulate that behavioural changes and chronic inflammation in LS may lead to systemic manifestations, including dyslipidaemia and an increased risk of hypertension (HTN), type II diabetes mellitus (DM2) and cardiovascular disease, as in other inflammatory conditions like psoriasis 1,2,6 . These and related conditions are grouped under metabolic syndrome (MS), which has a population prevalence of 20–30% and is more prevalent in women over the age of 50 years 7 .…”

Oral lichen planus and associated comorbidities: An approach to holistic health

“…[89101112] Current published literature has emphasized that chronic inflammation, endocrine dysfunction, and oxidative stress, frequently associated with mucocutaneous disorders, may serve as potential predisposing risk factors for the development of the MS.[13] According to a recent study by Sadr Eshkevari et al , a majority of patients with LP presented with features of DM, hypertension, MS, and dyslipidemia [Table 2]. [14]…”