Prevalence of Metabolic Syndrome in Patients with Mucosal Lichen Planus: A Case–Control Study

Baykal, Leyla; Arıca, Deniz Aksu; Yaylı, Savaş; Örem, Asım; Bahadır, Sevgi; Altun, Ece; Yaman, Hüseyin

doi:10.1007/s40257-015-0142-8

Cited by 37 publications

(67 citation statements)

References 27 publications

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“…Similar results were observed by Baykel et al in their study with 26 (32.9%) of 70 LP patients suffering from hypertension with a p value of 0.027. 17 However this was not in accordance with the study done by Salvador Arias-Santiago et al were they could not prove any association between LP and hypertension. 7 …”

Section: Blood Pressurementioning

confidence: 58%

“…25 While in a study done by Beykal et al among LP patients, they found there was no significant derangement in triglyceride levels and HDLC levels with p values for the same being 0.182 and 0.142 respectively. 17 Waist circumference 25 (62.5%) patients with LP had a higher waist circumference than that specific for the ethnic group. Though there were a higher percentage of LP patients with increased waist circumference when compared to the controls (57.5%), the p value was 0.599 thus making it insignificant.…”

Section: Serum Lipidsmentioning

confidence: 88%

“…They also concluded that presence of mucosal LP has an even higher risk of developing metabolic syndrome. 17 However in a study done by Krishnamoorthy et al, only 27% of the patients with mucosal LP had metabolic syndrome which was not significant.…”

Section: Metabolic Syndromementioning

confidence: 88%

“…16 The association between metabolic syndrome and lichen planus is not well established though a few studies have shown higher rate of metabolic syndrome in patients with lichen planus. 17 In addition to metabolic syndrome as a whole, there are studies describing higher incidence of individual components like raised waist circumference, hypertension, low HDLC, raised triglycerides and raised fasting blood glucose in LP patients. 7 In our study we have tried to find out the presence of any association between lichen planus and metabolic syndrome.…”

Section: Clinical Patterns Of Lichen Planus In the Studymentioning

confidence: 99%

“…Similar findings of impaired fasting glucose levels were recorded by Baykel et al in a case control study among LP patients, with a P value of 0.012. 17 Among 23 patients with oral erosive LP, Grinspan found higher prevalence of diabetes mellitus and hypertension (1963) and later was named as Grinspan syndrome. 24 …”

Section: Fasting Blood Sugarmentioning

confidence: 99%

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A prospective case control study on metabolic syndrome in lichen planus in a tertiary care centre

2017

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Background: Lichen planus is an autoimmune, inflammatory papulosquamous disease affecting skin and mucous membrane with a possible association with the parameters of metabolic syndrome.Methods: We carried out a hospital based case control study among patients attending DVL OPD during a period of 1.5 years (January 2015 - May 2016). Study population included 40 cases of LP and 80 age and sex matched controls. Relevant history, clinical examination and blood investigations were done. Diagnosis of MS was made based on IDF criteria.Results: There was no significant association between metabolic syndrome and lichen planus (p=0.292). Although there was higher prevalence of hypertension (47.5% vs. 27.5%, p=0.029), triglyceride level (25% vs. 10%, p=0.030) and low HDLC levels (65% vs. 45%, p=0.039). We could not establish significant association between FBS and waist circumference with LP.Conclusions: Though metabolic syndrome was not significantly associated with LP, its components such as hypertension, triglycerides and low HDLC levels were significantly associated with LP as per the study. Therefore patients with LP need to be screened to rule out each of these parameters to avoid later complications.

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Section: Blood Pressurementioning

confidence: 58%

Section: Serum Lipidsmentioning

confidence: 88%

Section: Metabolic Syndromementioning

confidence: 88%

Section: Clinical Patterns Of Lichen Planus In the Studymentioning

confidence: 99%

Section: Fasting Blood Sugarmentioning

confidence: 99%

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A prospective case control study on metabolic syndrome in lichen planus in a tertiary care centre

2017

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Association between metabolic syndrome and prevalent skin diseases: A systematic review and meta‐analysis of case‐control studies

Sodagar,

Ghane,

Heidari

et al. 2023

Health Science Reports

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Background and AimMetabolic syndrome (MetS) is a well‐known noncommunicable disease that plays a significant role in emerging other chronic disorders and following complications. MetS is also involved in the pathophysiology of numerous dermatological diseases. We aim to evaluate the association of MetS with the most prevalent dermatological diseases.MethodsA systematic search was carried out on PubMed, Science Direct, Web of Science, Cochrane, as well as the Google Scholar search engine. Only English case‐control studies regarding MetS and any skin disease from the beginning of 2010 up to November 15, 2022, were selected. The study was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA).ResultsA total of 37 studies (13,830 participants) met the inclusion criteria. According to our result, patients with psoriasis, hidradenitis suppurativa (HS), vitiligo, androgenetic alopecia (AGA), and lichen planus (LP) have a higher chance of having MetS compared to the general population. Furthermore, people with seborrheic dermatitis (SED) and rosacea are more prone to insulin resistance, high blood pressure (BP), and higher blood lipids. After pooling data, the meta‐analysis revealed a significant association between MetS and skin diseases (pooled odds ratio [OR]: 3.28, 95% confidence interval: 2.62−4.10). Concerning the type of disease, MetS has been correlated with AGA (OR: 11.86), HS (OR: 4.46), LP (OR: 3.79), and SED (OR: 2.45). Psoriasis also showed a significant association but with high heterogeneity (OR: 2.89). Moreover, skin diseases and MetS are strongly associated in Spain (OR: 5.25) and Thailand (OR: 11.86). Regarding the metaregression model, the effect size was reduced with increasing age (OR: 0.965), while the size increased with AGA (OR: 3.064).ConclusionsMetS is closely associated with skin complications. Dermatologists and other multidisciplinary teams should be cautious while treating these patients to prevent severe complications resulting from MetS.

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Metabolic syndrome in patients with lichen planus: A case‐control study

Mathur,

Thakur,

Jaiswal

et al. 2023

Skin Health and Disease

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BackgroundLichen Planus (LP) is a chronic dermatosis affecting the skin and mucous membranes. Chronic inflammation and oxidative stress in patients with LP is a trigger predisposing to Metabolic Syndrome.ObjectivesTo study the association of Metabolic Syndrome in patients with LP.Materials and MethodsA hospital‐based prospective case‐control study was conducted from April 2021 to January 2023 including 75 histopathologically confirmed patients with LP and 82 age and sex‐matched controls according to the inclusion and exclusion criteria. Metabolic Syndrome was diagnosed using Modified National Cholesterol Education Programme Adult Treatment Panel III criteria. Statistical analysis of the data was performed using Statistical Package for the Social Sciences software, version 26. The chi‐square test was used for data analysis.ResultsThe majority (30.6%) of the patients belonged to the age group 31–40 years. The mean age of patients with LP was 46.13 ± 14.9 years. Female predominance (69.3%) was observed in our study. Patients with classic LP (54.6%) were predominantly observed. Metabolic Syndrome was significantly prevalent in LP patients than in controls (32% vs. 13.4%, p = 0.005, OR 3.037) and was significantly associated with morphology (only oral mucosal involvement, 61.5%, p 0.027, OR 3.9), severity (severe LP, 58.6%, p < 0.001, OR 7.79), and duration of the disease (≥6 months, 55.5%, p 0.001, OR 5.42). 71% of Metabolic Syndrome was observed in females (p 0.847). Among patients with metabolic syndrome, the majority belonged to the age group between 31 and 40 years (37.5%, p 0.378). Systolic and Diastolic Blood Pressure values (≥130/85 mm of Hg), Serum Triglycerides (≥150 mg/dl), and Low‐Density Lipoprotein (>130 mg/dl) were significantly elevated, and High‐Density Lipoprotein (<40 mg/dl) was significantly low in LP than in controls (p < 0.05).ConclusionThe study showed a significant association of Metabolic Syndrome in patients with LP. Thus, patients with LP need to be screened to avoid complications associated with Metabolic Syndrome that is, Diabetes Mellitus, Cardiovascular Disease, colorectal cancer, and stroke.

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Prevalence of Metabolic Syndrome in Patients with Mucosal Lichen Planus: A Case–Control Study

Abstract: The patients with LP, particularly those with mucosal involvement, have a higher prevalence of MS, which is associated with a risk for cardiovascular diseases and diabetes mellitus.

Cited by 37 publications

References 27 publications

A prospective case control study on metabolic syndrome in lichen planus in a tertiary care centre

A prospective case control study on metabolic syndrome in lichen planus in a tertiary care centre

Association between metabolic syndrome and prevalent skin diseases: A systematic review and meta‐analysis of case‐control studies

Metabolic syndrome in patients with lichen planus: A case‐control study

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