Homeopathic Approach to COVID-19: A Review

Hasan, Nazmul; Nayem, Mesbah Uddin Md. Rezwanun; Mohshinuzzaman, Mohammad; Biswas, Anwar H; Kayes, Md. Emrul; Hakim, M. A.; Uddin, Nizam; Alom, Md. Jahangir

doi:10.18034/mjmbr.v7i1.493

Cited by 4 publications

(3 citation statements)

References 14 publications

(9 reference statements)

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“…249 Interestingly, the repertorisation of the common symptoms of the disease with the Radar software results in the presence of Silicea and Arsenicum in the first positions. 250 In another study, the second is also one of the most prescribed. 251 Their respective pathogenesis shows a close link with the small intestine, where the NOS2 and AOC1 genes are enhanced (►Table 3).…”

Section: Sectionmentioning

confidence: 96%

The Intestinal Perspective of COVID-19: NOS2 and AOC1 Genes as Epidemiological Factors, and a Homeopathic Approach to their Functional Improvement

Macías¹

2020

Homœopathic Links

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The new pandemic disease COVID-19 has wreaked havoc worldwide. Its infectious agent, SARS-CoV-2, uses two key human enzymes called angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) to invade body cells. The first one is encoded by the ACE2 gene and the second by the TMPRSS2 gene. Both have an outstanding expression of RNA and proteins in the small intestine compared with other tissues. This prominent location may be related to the main entry route of SARS-CoV-2 into the organism. In the process of infection, two other genes can play a fundamental role: NOS2, which expresses inducible nitric oxide synthase (iNOS), and AOC1, which encodes diamine oxidase (DAO). Both also highlight in the small intestine and are involved in polyamine metabolism. These biogenic amines are important for viral replication, being enhanced when NOS2 and AOC1 genes are downregulated. In addition, NOS2 shows a negative correlation with ACE2 and TMPRSS2, while nondegraded histamine by DAO can lead to an upregulation of both genes on which the virus depends. Taken together, these data suggest that inhibition or underexpression of NOS2 and AOC1 determines the susceptibility to get sick, increasing the risk of infection. On the other hand, a therapeutic approach to the disease could be made with homeopathic medicines. Experiments show the remedies' ability to stimulate gene and protein expression, but a correlation between the symptoms of each drug and these expressions has not yet been established. Here an analysis of the pathogenesis of Silicea terra and Arsenicum album supported on the scientific literature is done. The objective is to propose a theory about their relationship with key genes whose protein expressed in deficiency can give rise to the chain of events that imbalance the internal environment (homeostasis) and allow the development of symptoms. Silicea seems to be related to NOS2 (gene)/iNOS (protein) and Arsenicum with AOC1 (gene)/DAO (protein), being necessary to carry out studies to corroborate these links. Therefore, the aim of this article is to show the importance of NOS2 and AOC1 genes in the development of COVID-19 and to propose a line of investigation to evaluate if homeopathy can improve their protein expression.

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Section: Sectionmentioning

confidence: 96%

The Intestinal Perspective of COVID-19: NOS2 and AOC1 Genes as Epidemiological Factors, and a Homeopathic Approach to their Functional Improvement

Macías¹

2020

Homœopathic Links

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“…In homeopathic treatment, every patient after being fully diagnosed and analyzed received medicines. The medical grounds of homeopathy have a clear protocol of sanitation, antibiotics, and vaccinations to control the infections [29][30][31].…”

Section: Role Of Homeopathy and Ayurveda In Covid-19mentioning

confidence: 99%

Ayurveda and Allopathic Therapeutic Strategies in Coronavirus Pandemic Treatment 2020

Talwar

Sood²,

Kumar³

et al. 2020

Curr Pharmacol Rep

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Purpose of Review In the last month of 2019, i.e., December, COVID-19 hit Wuhan city in China. Since then, it has infected more than 210 countries and nearly about 33.4 million people with one million deaths globally. It is a viral disease with flu-like symptoms; hence, prevention and management is the best option to be adopted for its cure. Recent Findings Many healthcare systems, scientists, and researchers are fighting for the cure of this pandemic. Ayurvedic and allopathic treatments have been studied extensively and approached for the cure of COVID-19. In addition to ayurvedic treatments, the Ministry of Ayush, India, has also recommended many remedies to boost up immunity. Allopathic studies involved several antiviral drugs which were used in different combinations for the treatment of COVID-19. Summary Comparative analysis of Ayurveda and allopathic treatment strategies were carried out in the present study. Depending upon the patient’s conditions and symptoms, Ayurveda is useful for the treatment of COVID-19. Allopathic treatments inhibit viral infection by targeting majorly endocytosis, and angiotensin-converting enzyme (Ace) receptor signaling. In this article, we summarize different ayurvedic and allopathic medicines and treatment strategies which have been used for the treatment of COVID-19, a global pandemic.

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“…Homoeopathy has a well-established history in epidemic management (9,10).In case of COVID-19, homoeopathy medicines has been tested for preventive measures with a focus has been on identifying an effective universal prophylactic medicine or as personalized homeopathic treatment for patients or as an adjuvant therapy (11)(12). Identification of potential homeopathic medicine for treatment of COVID-19 needs a stepwise process where the first step is characterization of clinical symptoms of COVID-19positive patients and identification of probable effective remedies.…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics based homeopathic Remedy Profiling of COVID-19 Patients: A Retrospective Cohort Study

Aphale¹,

Sharma²,

Yeola³

et al. 2022

IJAM

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Objective: The objective of the study was to recognize core symptoms associated with COVID-19 positivity, its impact on mental health of patients and to identify indicated homeopathic remedies for COVID-19. Methods: In this pilot study, 25 confirmed COVID-19 patients admitted at Dedicated COVID Hospital (DCH) established under Dr. D Y Patil Vidyapeeth campus took part in survey questionnaire entitled as “Health impact survey for clinical features and patient profiles of COVID 19: Based on Homoeopathic perspective” observed by three independent observers. Based on the survey, specificity and sensitivity of symptoms was analyzed by three independent physicians to perform remedy analysis in order to identify indicated homeopathic medicines for COVID-19 in mild to moderate cases. Results: A total of 25 patients were included in study. Out of 25, 16 patients did not have any co-morbidity while 9 patients had diabetes, blood pressure or thyroid as one of the co-morbidities. The mean age of the patients was 39.4 years ± 12.6 where mean age of patients without co-morbidity was significantly lower than the patients with co-morbidities. The major symptoms were found to be fever (76%), cough (76%), shortness of breath (72%), sore throat (56%), fatigue (80%), loss of smell (40%) and Loss of taste(48%). Likelihood ratio of a positive test was found to be higher for Loss of smell, Loss of taste and Cough. Mixed and contrasting responses were reported by the study subjects on mental health impact. Majority of patients showed mild negative impact on mental health. In remedy analysis total 6 homeopathic medicines were observed with most commonly indicated being Carbo vegetabilis (70.66%), Antimonium tartaricum (10.66%), Arsenic album (9.33%) and Bryonia alba Linn. (4%) in 30C potency. Conclusion: The observation from current study demonstrate that fever, cough, shortness of breath, sore throat, fatigue, loss of smell and Loss of taste are most common symptoms associated with COVID-19 and Carbo vegetabilis, Antimonium tartaricum, Arsenic album and Bryonia alba Linn. are most frequently indicated homeopathic medicines for COVID-19.

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Homeopathic Approach to COVID-19: A Review

Cited by 4 publications

References 14 publications

The Intestinal Perspective of COVID-19: NOS2 and AOC1 Genes as Epidemiological Factors, and a Homeopathic Approach to their Functional Improvement

The Intestinal Perspective of COVID-19: NOS2 and AOC1 Genes as Epidemiological Factors, and a Homeopathic Approach to their Functional Improvement

Ayurveda and Allopathic Therapeutic Strategies in Coronavirus Pandemic Treatment 2020

Clinical characteristics based homeopathic Remedy Profiling of COVID-19 Patients: A Retrospective Cohort Study

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