Ayurveda and Allopathic Therapeutic Strategies in Coronavirus Pandemic Treatment 2020

Talwar, Shivangi; Sood, Shivani; Kumar, Jayant; Chauhan, Ritu; Sharma, Mamta; Tuli, Hardeep Singh

doi:10.1007/s40495-020-00245-2

Cited by 17 publications

(17 citation statements)

References 78 publications

(66 reference statements)

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“…Recent literature has shown that systematic and integrative use of traditional medicine and conventional medicine offered better clinical outcomes in China with no adverse drug reactions and prevented deterioration of the disease (46)(47)(48). Similar findings are also available from India (49,50). In-silico and preclinical studies on several medicinal plants included in Ayurvedic protocols against various stages of SARS-CoV-2 infection also yielded significant results (51,52).…”

Section: Discussionmentioning

confidence: 63%

Ayurvedic Response to COVID-19 Pandemic in Kerala, India and Its Impact on Quarantined Individuals – A Community Case Study

Joseph

Iyer

Pillai³

2021

Front. Public Health

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The SARS-CoV-2 infection has resulted in massive loss of valuable human lives, extensive destruction of livelihoods and financial crisis of unprecedented levels across the globe. Kerala, a province in India, like the rest of the country, launched preventive and control measures to mitigate the impact of COVID-19 early in 2020. The Government of Kerala started 1206 Ayur Raksha Clinics and associated Task Forces across the state in April 2020 to improve the reach and penetration of Ayurvedic preventive, therapeutic and convalescent care strategies for the COVID-19 pandemic. The implementation framework of the strategy was properly designed, and had a decentralized, people-centered, and participatory approach. Kerala has robust public health machinery with adequate human resource and infrastructure in the conventional medicine sector. This community case study examines how the decentralized organizational framework was effectively utilized for facilitating the delivery of Ayurvedic services in the COVID-19 situation. Key observations from the study are: Ayurvedic programs implemented systematically, under an organized framework with social participation enables wider utilization of the services. Such a framework is easily replicable even in resource-poor settings. Rather than a pluralistic approach, an integrative health system approach may be more viable in the Kerala scenario in public health emergencies.

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Section: Discussionmentioning

confidence: 63%

Ayurvedic Response to COVID-19 Pandemic in Kerala, India and Its Impact on Quarantined Individuals – A Community Case Study

Joseph

Iyer

Pillai³

2021

Front. Public Health

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“…Moreover, these drugs are associated with various side effects such as insomnia, gastrointestinal adverse effects, immune suppression, and cardiac rhythm disorders (Table 1). 8‐19 Thus, there is an urgent need for identifying efficacious molecules/phytochemicals against SARS-CoV-2.…”

Section: Introductionmentioning

confidence: 99%

Antiviral Potential of Indian Medicinal Plants Against Influenza and SARS-CoV: A Systematic Review

Khuntia

Sharma

Wadhawan

et al. 2022

Natural Product Communications

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The COVID-19 pandemic has posed a significant threat to human health due to the lack of drugs that can potentially act against SARS-CoV -2. Also, even after the emergency approval of WHO, the vaccines’ efficacy is still a question, and people are getting reinfections. Previous studies have demonstrated the efficacy of traditional medicinal plants against influenza and SARS coronavirus. The present article aims to review potential phytochemicals from Indian medicinal plants that may be used against SARS-CoV-2. Articles published in the English language between 1992 and 2021 were retrieved from Embase, PubMed, and Google scholar using relevant keywords, and the scientific literature on efficacies of Indian medicinal plants against SARS-CoV and influenza virus were analyzed. The initial search revealed 1304 studies, but, on subsequent screening, 115 eligible studies were reported. Twenty research articles investigating traditional medicinal plant extracts and metabolites against SARS-CoV and influenza A virus in in vitro and in vivo systems satisfied the search criteria. The studies reported that plant extracts and active compounds such as glycyrrhizin, 14-α-lipoyl andrographolide, and curcumin from medicinal plants such as Yashtimadhu ( Glycyrrhiza glabra), Bhunimba ( Andrographis paniculata), and Haridra ( Curcuma longa) are effective against the various phases of the virus life cycle, viz., virus-host cell attachment, viral replication, 3CL protease activity, neuraminidase activity, adsorption and penetration of the virus. As per ancient Indian literature, plants in Ayurveda possess Rasayana (revitalizing) and Jwara hara (antipyretic, anti-inflammatory) properties. This evidence may be used to conduct experimental and clinical trials to study the underlying mechanisms and efficacy of antiviral properties of Indian medicinal plants against SARS-CoV-2.

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“…Members of this family are mainly known to cause respiratory or intestinal diseases in various creatures including humans (Tuli et al 2021a). Recent research suggests that natural plant-based compounds such as phytochemicals including flavonoids, alkaloids, and others may be useful in the development of safe SARS-CoV treatments (Talwar et al 2020;Vardhan and Sahoo 2020;Silveira et al, 2020;Tuli et al 2021a;Tuli et al 2021b;). In the year 2020, Vardhan and Sahoo (2020) pursued in silico computational analysis of phytochemicals including glycyrrhizic acid, limonin, 7-deacetyl-7-benzoylgedunin, maslinic acid, corosolic acid, obacunone, and ursolic acid and suggested their utility as promising drugs to target proteins of SARS-CoV-2.…”

Section: Introductionmentioning

confidence: 99%

Molecular Docking studies of Apigenin, Kaempferol, and Quercetin as potential target against spike receptor protein of SARS COV

Tuli

Sood²,

Pundir

et al. 2022

J Exp Bio & Ag Sci

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COVID-19 has been categorized as a pandemic in early 2020 and is known to cause by Severe Acute Respiratory Syndrome Coronavirus (SARS–CoV2). Numerous investigators and people in the scientific community are trying to find a superlative way to avert and cure the ailment by using phytochemicals. Abundant studies have revealed that flavonoids can be very operative in averting virus-mediated infection. The purpose of this study was to accomplish molecular docking studies among plant-derived flavonoids (Apigenin, Kaempferol, and Quercetin) and spike receptor (PDB ID: 2AJF) protein of coronavirus. Pyrx virtual screening tool and biovia discovery studio visualizer were utilized in the current molecular docking investigations. Outcomes of docking studies exposed that selected phytochemicals have interacted with targeted spike receptor protein with binding energies in the range of -6.3 to -7.3 kcal. In conclusion among the various selected ligands, quercetin may be a better inhibitor for the deactivation of SARS-Coronavirus.

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Ayurveda and Allopathic Therapeutic Strategies in Coronavirus Pandemic Treatment 2020

Cited by 17 publications

References 78 publications

Ayurvedic Response to COVID-19 Pandemic in Kerala, India and Its Impact on Quarantined Individuals – A Community Case Study

Ayurvedic Response to COVID-19 Pandemic in Kerala, India and Its Impact on Quarantined Individuals – A Community Case Study

Antiviral Potential of Indian Medicinal Plants Against Influenza and SARS-CoV: A Systematic Review

Molecular Docking studies of Apigenin, Kaempferol, and Quercetin as potential target against spike receptor protein of SARS COV

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