2020
DOI: 10.1055/s-0040-1715601
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The Intestinal Perspective of COVID-19: NOS2 and AOC1 Genes as Epidemiological Factors, and a Homeopathic Approach to their Functional Improvement

Abstract: The new pandemic disease COVID-19 has wreaked havoc worldwide. Its infectious agent, SARS-CoV-2, uses two key human enzymes called angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) to invade body cells. The first one is encoded by the ACE2 gene and the second by the TMPRSS2 gene. Both have an outstanding expression of RNA and proteins in the small intestine compared with other tissues. This prominent location may be related to the main entry route of SARS-CoV-2 into the organ… Show more

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Cited by 2 publications
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“…Given that the loss of taste or smell is highly correlated with abnormal immune responses in the olfactory regulatory networks [ 49 ], the gene could participate in the regulation of olfactory impairment through these responses. AOC1 (ENSG00000002726.20, predicted by LASSO) and another epidemiological factor, NOS2, are the two major factors reported to be associated with the neurological disorders causing taste and smell loss [ 50 ], validating the efficacy and accuracy of our prediction. CDC42BPB (ENSG00000259515.1, predicted by LightGBM) could be related to a viral infection that decreases the sense of smell or taste.…”
Section: Discussionmentioning
confidence: 65%
“…Given that the loss of taste or smell is highly correlated with abnormal immune responses in the olfactory regulatory networks [ 49 ], the gene could participate in the regulation of olfactory impairment through these responses. AOC1 (ENSG00000002726.20, predicted by LASSO) and another epidemiological factor, NOS2, are the two major factors reported to be associated with the neurological disorders causing taste and smell loss [ 50 ], validating the efficacy and accuracy of our prediction. CDC42BPB (ENSG00000259515.1, predicted by LightGBM) could be related to a viral infection that decreases the sense of smell or taste.…”
Section: Discussionmentioning
confidence: 65%