Historical and modern research on propolis and its application in wound healing and other fields of medicine and contributions by Polish studies

Rojczyk, Ewa; Klama-Baryła, Agnieszka; Łabuś, Wojciech; Wilemska-Kucharzewska, Katarzyna; Kucharzewski, Marek

doi:10.1016/j.jep.2020.113159

Cited by 47 publications

(34 citation statements)

References 124 publications

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“…Propolis (Pro) is the natural beehive resinous composite that is collected from exudates and buds of diverse plants by honeybees, amalgamated with wax, pollen and bees' enzyme. Pro exhibited numerous bioactive compounds and bioactivities and was effectually employed in plentiful pharmacological and biomedical applications [27], including its powerful antimicrobial action, inflammatory, antioxidant, and wound healing potentiality [28][29][30]. The bee Pro could efficiently synthesize metals' NPs (e.g., silver, gold, and selenium), stimulated by Pro content from biomolecules like flavonoids, alkaloids, phenols, terpenoids, and steroids [31][32][33].…”

Section: Introductionmentioning

confidence: 99%

“…Wound healing comprises complicated multistep processes affected with varied external and internal factors; skin injury is regularly accompanied by microbial infections and apparent inflammation [34]; these added aspects direct to further required therapies with an extended duration that include antimicrobial and anti-inflammatory agents. The misuse/overuse of antibiotics instigated the emergence of multiple resistant microbial pathogens that require innovative antimicrobial agent/compounds for their fighting [30].…”

Section: Introductionmentioning

confidence: 99%

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Formulation of Insect Chitosan Stabilized Silver Nanoparticles with Propolis Extract as Potent Antimicrobial and Wound Healing Composites

Al-Saggaf

2021

International Journal of Polymer Science

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Skin wounds are frequently influenced with microbial infections and inflammation, which need innovative agents for disputing them. Chitosan (Csn) was extracted from larvae of BSF “black soldier fly, Hermetia illucens” and ethanolic propolis extract (Pro) was employed for synthesizing silver nanoparticles (Ag-NPs), using facile biogenic protocol. The BSF-Csn was acquired with a yield of 1.56%, 91.3% deacetylation degree, and 88.600 Dalton molecular weight. The Ag-NPs were effectually biosynthesized using Pro, with a mean diameter of 8.73 nm and zeta potential of -21.34 mV. The antimicrobial activities assessment of insect Csn, Pro, synthesized Ag-NPs with Pro, and their composite against skin pathogens (Staphylococcus aureus and Candida albicans) revealed the elevated efficiency of the individual agents and the superior action of their composite (Csn/Pro/Ag-NPs), with 26.3 and 23.4 mm inhibition zones and inhibitory concentrations of 35.0 and 45.0 μg/mL from the composite toward S. aureus and C. albicans, respectively, which exceeded the actions of commercial antibiotics. The treatment of rat’s wounds with this composite promisingly led to faster healing of wounds and absence of inflammation and infection signs. The powerful actions of Csn/Pro/Ag-NPs as antimicrobial and wound healing composite strongly advocate their applications for skin protection, disinfection, and regeneration.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Formulation of Insect Chitosan Stabilized Silver Nanoparticles with Propolis Extract as Potent Antimicrobial and Wound Healing Composites

Al-Saggaf

2021

International Journal of Polymer Science

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“…Propolis biological effects result from a synergistic action of its components [ 24 ]. Investigating the chemical composition of a given sample and its geographical origin is also necessary to ensure data reproducibility and the study’s scientific value [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Apoptosis-related gene expression induced by Colombian propolis samples in canine osteosarcoma cell line

et al. 2021

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Background and Aim: Osteosarcoma (OSA) is the most common bone tumor in canines and humans. This study aimed to assess the cytotoxic and apoptotic effects of Colombian propolis samples on a canine OSA cell line (OSCA-8) by evaluating the expression of BCL-2, BAX, CASPASE 9, CASPASE 8, and TNFR1 genes involved in the apoptosis pathway. Materials and Methods: After treating the cells with five Colombian propolis samples (Usm, Met, Fus, Sil, and Caj), we evaluated cell viability and lactate dehydrogenase (LDH) release. Early and late apoptosis was determined by flow cytometry using annexin V/propidium iodide. Furthermore, the effects of three selected samples on gene expression were analyzed by real-time polymerase chain reaction. Results: The Colombian propolis samples reduced OSCA-8 cell viability and increased LDH release. All samples induced apoptosis significantly and upregulated BCL-2 and CASPASE 8 expression. Usm and Sil increased BAX expression, Met and Sil induced CASPASE 9 expression, and Usm increased TNFR1. Conclusion: Colombian propolis samples exhibited cytotoxic and apoptotic effects on canine OSA cells, and CASPASE 8 upregulation indicated apoptosis induction by the extrinsic pathway.

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“…Cases of treatment with ethanol extract of propolis have been described in the scientific literature since 1969. Ethanol extract of propolis has been used with chronic wounds, ulcers, surgical site infections, and burns, but also in cases of vaginitis or dental sockets [53][54][55][56][57]. Alongside its antibacterial, antiviral, and antifungal properties, due to the high content of flavonoids [24,25], it also promotes wound healing.…”

Section: Discussionmentioning

confidence: 99%

Biofilm Formation Reducing Properties of Manuka Honey and Propolis in Proteus mirabilis Rods Isolated from Chronic Wounds

et al. 2020

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Chronic wound infections are difficult to manage because of the biofilm formation in the wound environment. New measures for eliminating infections are necessary to increase the chance of wound healing. Apitherapy may be the new solution. The aim of this study was to assess the prevalence of wound infection factors and to examine the impact of Manuka honey and ethanol extract of propolis on biofilm formation of Proteus mirabilis isolated from chronic wound infections. According to the findings, the most frequent factors of infection are Staphylococcus aureus (46.1%), Pseudomonas aeruginosa (35.0%), and Proteus mirabilis (10.6%). Minimal inhibitory concentration and minimal bactericidal concentration values were assigned using the microbroth dilution test according to the Clinical and Laboratory Standards Institute. Biofilm of Proteus mirabilis isolates was formed in 96-well polystyrene plates and treated with Manuka honey (concentrations from 1.88% to 30.0%) and ethanol extract of propolis (1.0% to 40.0%). After 24 h, the biofilm viability was expressed by formazan absorbance (λ = 470 nm). Manuka honey reduced the biofilm viability in all, and ethanol extract of propolis in most, of the concentrations tested. Ethanol extract of propolis at the concentrations of 20.0% and 40.0%, reduced biofilm viability stronger than ethanol itself. With these results comes the conclusion that these substances can reduce biofilm formation.

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Historical and modern research on propolis and its application in wound healing and other fields of medicine and contributions by Polish studies

Cited by 47 publications

References 124 publications

Formulation of Insect Chitosan Stabilized Silver Nanoparticles with Propolis Extract as Potent Antimicrobial and Wound Healing Composites

Formulation of Insect Chitosan Stabilized Silver Nanoparticles with Propolis Extract as Potent Antimicrobial and Wound Healing Composites

Apoptosis-related gene expression induced by Colombian propolis samples in canine osteosarcoma cell line

Biofilm Formation Reducing Properties of Manuka Honey and Propolis in Proteus mirabilis Rods Isolated from Chronic Wounds

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