Histoplasmosis presenting as a mediastinal mass

Martin, Elise D; Lassiter, Randi; Hatley, Robyn M.; Walters, K. Christian

doi:10.1016/j.epsc.2017.11.020

Cited by 4 publications

(8 citation statements)

References 24 publications

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“…Acute pulmonary histoplasmosis characterized by imaging (see Figure 1) through pulmonary condensations with peribronchovascular distribution and unsystematized lobar, segmental, or multifocal localization in association with mediastinal and hilar adenopathies, reflects the granulomatous reaction and acute alveolar lesions [8]. The "tree-in-bud" pattern may be present.…”

Section: Acute Subacute and Chronic Pulmonary Histoplasmosismentioning

confidence: 99%

“…It can associate the appearance of a "bump," secondary to the mycotic infiltrate superimposed on the level of pre-existing emphysematous bubbles, with a pseudocavitary appearance. The differential diagnosis includes, first of all, pulmonary tuberculosis with a chronic appearance [8]. This can also be done with other chronic cases of pneumonia, including infections with tuberculous or non-tuberculous mycobacteria, or with other fungal infections: chronic invasive pulmonary aspergillosis, chronic pulmonary coccidioidomycosis or blastomycosis [10].…”

Section: Acute Subacute and Chronic Pulmonary Histoplasmosismentioning

confidence: 99%

“…The differential diagnosis is most frequently made with mediastinal granuloma; in mediastinal adenitis, the characteristic is the homogeneous appearance, while in mediastinal granuloma, we have an enlargement of the ganglion with an inhomogeneous appearance [8].…”

Section: Mediastinal Adenitismentioning

confidence: 99%

“…Granulomatous mediastinitis can be the first presentation of histoplasmosis in the form of a mediastinal mass detected on chest X-ray. The CT appearance is of a heterogeneous formation with paratracheal or subcarinal localization, secondary to caseous necrosis at the level of granulomas; internal calcifications may be present [8]. Also, the CT examination can highlight the occurrence of complications: for example, extrinsic compression of the trachea, esophagus, or superior vena cava, respectively fistulization at the mediastinal level, confirmed by the presence of air inclusions at the level of the granuloma.…”

Section: Mediastinal Granulomamentioning

confidence: 99%

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Pulmonary Histoplasmosis: Clinical and Imagistic Characteristics

Marc¹,

Trusculescu²,

Boeriu³

et al. 2023

Infectious Diseases

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Histoplasmosis is a condition caused by infection with a fungus, called Histoplasma capsulatum. The fungus can be found in the environment in an inactive form (spores), particularly in soil with great amount of bird or bat droppings. Infection occurs when a person inhales the spores and sometimes it can become aggressive especially when the immunity is low or the person has been in contact with a very high amount of fungi. The magnitude of symptoms correlates with the amount of fungi in contact with the patient. About 90% of patients are usually asymptomatic or presenting very few symptoms. However, in immunosuppressed patients, the infection can spread and affect several organs and systems like eyes, liver, spleen, central nervous system, hematological manifestations, joint manifestations. In patients with pre-existing lung disease chronic pulmonary histoplasmosis is not uncommon.

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Section: Acute Subacute and Chronic Pulmonary Histoplasmosismentioning

confidence: 99%

Section: Acute Subacute and Chronic Pulmonary Histoplasmosismentioning

confidence: 99%

Section: Mediastinal Adenitismentioning

confidence: 99%

Section: Mediastinal Granulomamentioning

confidence: 99%

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Pulmonary Histoplasmosis: Clinical and Imagistic Characteristics

Marc¹,

Trusculescu²,

Boeriu³

et al. 2023

Infectious Diseases

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“…Histoplasma capsulatum, an endemic mycosis in the United States, can present with a variety of clinical manifestations. Inhalation of airborne particles in the conidia state most commonly results in asymptomatic colonization of the lungs, though exposure can also trigger a robust inflammatory response manifesting with flu-like symptoms such as fever, shortness of breath, cough, and weight loss [1][2][3]. In most cases, acute pulmonary histoplasmosis is self-limiting.…”

Section: Introductionmentioning

confidence: 99%

An Unusual Clinical Outcome and Surgical Intervention for Mediastinal Histoplasmosis

Katsiroubas¹,

Harrison²

2022

Cureus

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Histoplasma capsulatum, an endemic mycosis in the United States, can result in a variety of clinical manifestations. When encountering histoplasmosis sequelae, such as mediastinal adenitis, granulomas, and fibrosing mediastinitis, surgical management may be an unexpected but necessary treatment. Due to the complexity of the mediastinum, it is imperative to have optimal operative planning. In this report, we present an unusual case of an inflammatory mediastinal mass in the setting of acute histoplasmosis resulting in left atrium compression and arrhythmias.

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