Histopathologic assessment of the entire endometrium in asymptomatic women

Mingels, Marjanka J.J.M.; Geels, Yvette P.; Pijnenborg, Johanna M.A.; Wurff, A.A. van der; Tilborg, Angela A.G. van; Ham, Maaike A.P.C. van; Massuger, Leon F.A.G.; Bulten, Johan

doi:10.1016/j.humpath.2013.05.011

Cited by 16 publications

(20 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Free radicals and cytokines induced by chronic inflammatory processes may initiate premalignant and malignant events within the endometrium. Moreover, this can produce unexpected endometrial changes in patients with uterine prolapse as in the present and previous studies [17,18,19]. This may account for the elevated risk of hyperplasia in menopausal patients treated for uterine prolapse.…”

Section: Discussionsupporting

confidence: 64%

“…Certain conditions such as endometrial hyperplasia are known to be associated with estrogen levels and endometrial cancer risk. Endometrial hyperplasia may occur in the endometrium of patients with uterine prolapse [17,18,19]. While the systemic estrogen expression and estrogen receptor play a primary role in premalignant and malignant lesions in patients without a prolapse [20], COX-2 induction due to inflammation may play a primary premalignant role in patients with prolapse [14,21].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Does Uterine Prolapse Alter Endometrial Cyclooxygenase 2 Expression and Promote the Development of Premalignant Lesions?

Genç¹,

Sivrikoz²,

Şahin³

et al. 2015

Gynecol Obstet Invest

View full text Add to dashboard Cite

Objective: The aim of this study was to evaluate the expression of cyclooxygenase 2 (COX-2) and its association with the development of premalignant lesions in gland structures of the endometrium in patients with uterine prolapse, a condition which exposes the uterus to mechanical and infectious stress. Methods: The study included 102 patients who underwent hysterectomy to correct grade 3-4 uterine prolapse and 105 patients who underwent hysterectomy for other causes. Endometrial gland structures underwent immunohistochemical staining and COX-2 expression was graded. Grades 0 and 1 represent low expression; grades 2 and 3 correspond to high levels of COX-2 expression. Results: The prevalence of grade 2-3 COX-2 expression was significantly higher in the endometrial gland structures of patients with prolapse and hyperplasia compared to the remaining patients (p = 0.014). Grade 0-1 COX-2 expression was significantly more common in the endometrial gland structures of patients without uterine prolapse or hyperplasia (p = 0.004). Among the patients without endometrial hyperplasia, COX-2 expression was elevated in the endometrial gland structures of those with uterine prolapse compared to those without prolapse. Conclusion: Elevated COX-2 expression may explain the presence of unexpected premalignant lesions of the endometrium in patients with uterine prolapse.

show abstract

Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Does Uterine Prolapse Alter Endometrial Cyclooxygenase 2 Expression and Promote the Development of Premalignant Lesions?

Genç¹,

Sivrikoz²,

Şahin³

et al. 2015

Gynecol Obstet Invest

View full text Add to dashboard Cite

show abstract

“…[29][30][31] We recently reported the prevalence of atypical hyperplasia in 6% of women who underwent a hysterectomy because of uterovaginal prolapse, after embedding the endometrial tissue in accordance with the SEE-End protocol. 32 In none of these women, endometrial intraepithelial carcinoma was found.…”

Section: Discussionmentioning

confidence: 92%

“…20 The introduction of the SEE-End protocol might contribute to a more accurate identification of endometrial pathology, as shown by the higher prevalence of endometrial pathology found in asymptomatic women after introduction of the new protocol. 32 Especially for the identification of endometrial intraepithelial carcinoma, the SEE-End protocol is recommended, …”

Section: Discussionmentioning

confidence: 99%

Müllerian precursor lesions in serous ovarian cancer patients: using the SEE-Fim and SEE-End protocol

et al. 2014

Self Cite

View full text Add to dashboard Cite

Serous ovarian cancer is suggested to develop from epithelium embryologically derived from the Mü llerian ducts. The aim of the current study is to thoroughly, analyze the epithelium derived from the Mü llerian ducts (cervix, endometrium and fallopian tubes) in serous ovarian cancer patients. Sixty women diagnosed with serous ovarian carcinoma were included in this multicentre, observational study. Tissues were embedded completely for histological assessment, in accordance with the SEE-Fim and SEE-End protocol (Sectioning and Extensively Examining of the Fimbriated end; and-Endometrium), and prevalence of cervical, as well as endometrial and tubal pathology was analyzed. In 31 (52%) cases, a pathologic lesion was identified, and in 16 (27%) of these cases coexistence of pathologic lesions. In 1 case, severe dysplasia was found in the cervix, in 9 (15%) cases endometrial intraepithelial carcinoma, in 19 (32%) cases atypical hyperplasia, and in 23 (43%) cases serous tubal intraepithelial carcinoma. Serous tubal intraepithelial carcinoma was seen significantly more often concurrent with endometrial atypical hyperplasia or endometrial intraepithelial carcinoma than with benign endometrium (64 vs 28%; P ¼ 0.01). To conclude, histological assessment of epithelium derived from Mü llerian ducts of serous ovarian cancer patients resulted in the identification of endometrial intraepithelial carcinoma, serous tubal intraepithelial carcinoma and/or endometrial atypical hyperplasia in more than half of cases. Coexistence of these pathologic lesions was common, and might represent an effect of field carcinogenesis or tumor implantation of migrating cells.

show abstract

“…5 Xenobiotic compounds that can trigger oxidative stress can also be toxic to the ovaries. 6 The whole morphological alteration in the ovary after DMPA therapy appeared to be the atresia of the follicular apparatus with degeneration of the growing follicles. 7 In addition to the ovary, endometrium also is an organ that can be affected by xenobiotics.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of green tea against ovarian and endometrial apoptoses in rats treated with depot medroxyprogesterone acetate

Veri

Aulia

Ratnawati

et al. 2015

Biomarkers and Genomic Medicine

View full text Add to dashboard Cite

Histopathologic assessment of the entire endometrium in asymptomatic women

Cited by 16 publications

References 19 publications

Does Uterine Prolapse Alter Endometrial Cyclooxygenase 2 Expression and Promote the Development of Premalignant Lesions?

Does Uterine Prolapse Alter Endometrial Cyclooxygenase 2 Expression and Promote the Development of Premalignant Lesions?

Müllerian precursor lesions in serous ovarian cancer patients: using the SEE-Fim and SEE-End protocol

Protective effect of green tea against ovarian and endometrial apoptoses in rats treated with depot medroxyprogesterone acetate

Contact Info

Product

Resources

About