2020
DOI: 10.1111/odi.13479
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Abstract: Oral squamous cell carcinoma (OSCC) is the most common malignant tumour of the oral cavity, representing the eighth most common cancer worldwide (Shield et al., 2017). Although OSCC usually occurs in males between the age of 60 and 80 years, a rise in OSCC incidence among younger subjects has been reported in recent years (Jeon et al., 2017). In particular, the frequency of OSCC among young adults has increased since the 1980s and to date these patients are 4%-12% of all OSCC cases (Muller, Pan, Li,

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Cited by 22 publications
(17 citation statements)
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“…41 Indeed, recent studies have suggested PNI as a predictor of decreased 5-year survival in OSCC patients. [42][43][44] Although PNI is a well-recognised prognostic factor in OSCC, it is not required for stage grouping in the 8th edition AJCC staging system. 45 Furthermore, the different prognostic significance levels of unifocal and multifocal PNI remain unclear.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…41 Indeed, recent studies have suggested PNI as a predictor of decreased 5-year survival in OSCC patients. [42][43][44] Although PNI is a well-recognised prognostic factor in OSCC, it is not required for stage grouping in the 8th edition AJCC staging system. 45 Furthermore, the different prognostic significance levels of unifocal and multifocal PNI remain unclear.…”
Section: Discussionmentioning
confidence: 99%
“…Among the advantages of using PNI are the ease of evaluation and the lack of influence from the anatomical characteristics of different oral subsites 41 . Indeed, recent studies have suggested PNI as a predictor of decreased 5‐year survival in OSCC patients 42–44 . Although PNI is a well‐recognised prognostic factor in OSCC, it is not required for stage grouping in the 8th edition AJCC staging system 45 .…”
Section: Discussionmentioning
confidence: 99%
“…Our methodology may be applied in future larger cohorts to generate uniformly applicable and objective imaging biomarkers for prognostic risk-stratification of OPSCC. Additionally, our approach enables inclusion of additional prognostic variables into PFS and OS models for risk-stratification of head/neck cancer subgroups [29].…”
Section: Discussionmentioning
confidence: 99%
“…Concerning the impact of chromosome 9 in the corresponding patients based on their age, our study showed no relation. Some studies have reported a borderline correlation between younger patients and specific genetic markers—combined or not with smoking status and HR-HPV persistent infection—in OSCC development and progression, but others support controversial results with no differences when comparing young to older patients [ 22 , 23 , 24 ]. In the current experimental study, we applied an innovative reference and calibration grid on conventional coverslips as a pilot screening mechanism for CISH slide evaluation.…”
Section: Discussionmentioning
confidence: 99%