Hinokinin, an Emerging Bioactive Lignan

Abstract

Abstract:Hinokinin is a lignan isolated from several plant species that has been recently investigated in order to establish its biological activities. So far, its cytotoxicity, its anti-inflammatory and antimicrobial activities have been studied. Particularly interesting is its notable anti-trypanosomal activity.

Dicorynamine and harmalan-N-oxide, two new β-carboline alkaloids from Dicorynia guianensis Amsh heartwood

“…35 Wood natural durability is extremely complex and additional 36 factors such as fungicidal and antioxidant action of extractives 37 besides density and lignin content may be involved (Schultz and 38 Nicholas, 2000). Antioxidant gives enhanced protection to wood 39 against both decay fungi and termites (Schultz and Nicholas, 2002) 40 and some of them have health benefit (Marcotullio et al, 2014). 41 The genus Dicorynia (Leguminoseae) consists of two woody 42 species distributed throughout the Guyana shield; Dicorynia 43 guianensis and D. paraensis.…”

Lignans and Their Derivatives from Plants as Antivirals

“…Hinokinin was first isolated from the ether extract of Chamecyparis obtusa in 1933, and it was also found in different species of Phyllanthus (Euphobiaceae) [39], Aristolochia (Aristolochiaceae) [40], Piper (Piperaceae) [41], Virola (Myristicaceae) [42], Linum (Linaceae) [43], and so on. The anti-inflammatory, antimicrobial activities, and cytotoxicity of this compound have been extensively studied [44]. Meanwhile, it showed good antiviral activities against human HBV [12], HIV [45], SARS-virus (SARS-CoV) [46], and human cytomegalovirus (HCMV) [47].…”

Medicinal Attributes of Lignans Extracted from Piper Cubeba: Current Developments

“…Lignans are secondary metabolites produced by plants that have a wide range of biological properties which are intrinsically related to their stereochemistry . This variety is related to the diversity of carbon skeletons that these classes of natural products present in plants . The denomination of the lignan class of compounds was created in 1936 by Haworth to describe a group of dimeric phenylpropanoids and, therefore, originated from a wide variety of lignans.…”

“… Possible chemical structures of hinokinin. Enantiomer pairs for cis ‐ 32 / 33 and trans ‐hinokinin ( 12 / 34 ) . (−)‐Hinokinin ( 12 ) and (+)‐Hinokinin ( 34 ) …”

“…In 2008, Bayindir et al. isolated (−)‐hinokinin from callus cultures of Linum corymbulosum and proposed two possible hypothetical pathways for the biosynthesis of (−)‐hinokinin starting from (+)‐pinoresinol (Scheme ) …”