Lignans and Their Derivatives from Plants as Antivirals

Cui, Qinghua; Du, Ruikun; Liu, Miaomiao; Rong, Lijun

doi:10.3390/molecules25010183

Cited by 111 publications

(70 citation statements)

References 89 publications

(111 reference statements)

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“…Similar to many other polyphenolic compounds in plants, lignans are reported to have an ecological role in helping plants to cope with biotic and abiotic stresses during growth and development [ 3 , 184 ]. Some of them are considered pharmacologically interesting due to their antiviral, antibacterial, antioxidant, and antitumor properties [ 185 ]. Due to their structure, lignans are effective antioxidants, and they have the potential to scavenge a harmful ROS that is usually overaccumulated under stress conditions.…”

Section: Lignansmentioning

confidence: 99%

The Role of Polyphenols in Abiotic Stress Response: The Influence of Molecular Structure

Šamec

Karalija

Šola

et al. 2021

Plants

360

224

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Abiotic stressors such as extreme temperatures, drought, flood, light, salt, and heavy metals alter biological diversity and crop production worldwide. Therefore, it is important to know the mechanisms by which plants cope with stress conditions. Polyphenols, which are the largest group of plant-specialized metabolites, are generally recognized as molecules involved in stress protection in plants. This diverse group of metabolites contains various structures, from simple forms consisting of one aromatic ring to more complex ones consisting of large number of polymerized molecules. Consequently, all these molecules, depending on their structure, may show different roles in plant growth, development, and stress protection. In the present review, we aimed to summarize data on how different polyphenol structures influence their biological activity and their roles in abiotic stress responses. We focused our review on phenolic acids, flavonoids, stilbenoids, and lignans.

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Section: Lignansmentioning

confidence: 99%

The Role of Polyphenols in Abiotic Stress Response: The Influence of Molecular Structure

Šamec

Karalija

Šola

et al. 2021

Plants

360

224

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“…Curcumin, a component of turmeric (Curcuma longa) has been described to have several functions in preventing or treating diseases, including cancers and viral infections [49]. It has also been demonstrated that curcumin is an antiviral compound, with activity against diverse viruses such as dengue virus (serotype 2) [50], herpes simplex virus [51], human immunodeficiency virus [52], Zika and Chikungunya [53] among others. Curcumin and its analogues have proved to be useful as HIV-1 integrase inhibitor [51,54].…”

Section: Introductionmentioning

confidence: 99%

“…It has also been demonstrated that curcumin is an antiviral compound, with activity against diverse viruses such as dengue virus (serotype 2) [50], herpes simplex virus [51], human immunodeficiency virus [52], Zika and Chikungunya [53] among others. Curcumin and its analogues have proved to be useful as HIV-1 integrase inhibitor [51,54]. Aloe BarbadensisAloe Vera) has been used medicinally for several thousands of years in many cultures; from ancient Egypt, Greece, and…”

Section: Introductionmentioning

confidence: 99%

In silico studies reveal potential antiviral activity of phytochemicals from medicinal plants for the treatment of COVID-19 infection

Pandit

Latha

2020

Preprint

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The spread of COVID-19 across continents has led to a global health emergency. COVID-19 disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected nearly all the continents with around 1.52 million confirmed cases worldwide. Currently only a few regimes have been suggested to fight the infection and no specific antiviral agent or vaccine is available. Repurposing of the existing drugs or use of natural products are the fastest options available for the treatment. The present study is aimed at employing computational approaches to screen phytochemicals from the medicinal plants targeting the proteins of SARS-CoV2 for identification of antiviral therapeutics. The study focuses on three target proteins important in the life cycle of SARS-CoV-2 namely Spike (S) glycoprotein, main protease (Mpro) and RNA-dependent RNA-polymerase (RdRp). Molecular docking was performed to screen phytochemicals in medicinal plants to determine their feasibility as potential inhibitors of these target viral proteins. Of the 30 plant phytochemicals screened, Silybin, an active constituent found in Silybum marianum exhibited higher binding affinity with targets in SARS-CoV-2 in comparison to currently used repurposed drugs against SARS-CoV-2. Withaferin A from Withania somnifera also showed significant binding to the targets proteins. In addition, phytochemicals from Tinospora cordiofolia and Aloe barbadensis displayed good binding energetics with the target proteins in SARS-CoV-2. These results provide a basis for the use of traditional medicinal plants as alternative lines of treatment for COVID-19 infection.

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“…Lignans are natural products characterized by a phenylpropanoid core (C 6 C 3 unit). Structurally, they are composed of two or more phenylpropanoid units as a basic scaffold [26][27][28]. Compounds 1, 4, and 5 are classified as phenylpropanoids, which contain a planar methylenedioxyphenyl moiety with allyl group [28].…”

Section: Isolation and Identification Of Compounds From P Pellucida mentioning

confidence: 99%

Isolation and Characterization of Phenylpropanoid and Lignan Compounds from Peperomia pellucida [L.] Kunth with Estrogenic Activities

et al. 2020

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Extracts of Peperomia pellucida [L.] Kunth have previously been demonstrated to have in vivo estrogenic-like effects, thereby functioning as an anti-osteoporotic agent. However, the compounds responsible for these effects have not yet been determined. Therefore, the aim of this study is to isolate and elucidate potential compounds with estrogenic activity. The structures of the isolated compounds were identified using 1D 1H and 13C-NMR and confirmed by 2D FT-NMR. The estrogenic activity was evaluated using the E-SCREEN assay, and a molecular docking study was performed to predict the binding affinity of the isolated compounds to estrogen receptors. In this experiment, we successfully isolated three phenylpropanoids and two lignan derivatives, namely, 6-allyl-5-methoxy-1,3-benzodioxol-4-ol (1), pachypostaudin B (2), pellucidin A (3), dillapiole (4), and apiol (5). Among these compounds, the isolation of 1 and 2 from P. pellucida is reported for the first time in this study. Activity assays clearly showed that the ethyl acetate extract and its fractions, subfractions, and isolated compounds exerted estrogenic activity. Methanol fraction of the ethyl acetate extract produced the highest estrogenic activity, while 1 and 2 had partial agonist activity. Some compounds (derivates of dillapiole and pellucidin A) also had, in addition, anti-estrogenic activity. In the docking study, the estrogenic activities of 1–5 appeared to be mediated by a classical ligand-dependent mechanism as suggested by the binding interaction between the compounds and estrogen receptors; binding occurred on Arg 394 and His 524 of the alpha receptor and Arg 346 and His 475 of the beta receptor. In summary, we reveal that P. pellucida is a promising anti-osteoporotic agent due to its estrogenic activity, and the compounds responsible for this activity were found to be lignan and phenylpropanoid derivatives. The presence of other compounds in either the extract or fraction may contribute to a synergistic effect, as suggested by the higher estrogenic activity of the methanol fraction. Hence, we suggest further research on the osteoporotic activity and safety of the identified compounds, especially regarding their effects on estrogen-responsive organs.

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Lignans and Their Derivatives from Plants as Antivirals

Cited by 111 publications

References 89 publications

The Role of Polyphenols in Abiotic Stress Response: The Influence of Molecular Structure

The Role of Polyphenols in Abiotic Stress Response: The Influence of Molecular Structure

In silico studies reveal potential antiviral activity of phytochemicals from medicinal plants for the treatment of COVID-19 infection

Isolation and Characterization of Phenylpropanoid and Lignan Compounds from Peperomia pellucida [L.] Kunth with Estrogenic Activities

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