Dicorynamine and harmalan-N-oxide, two new β-carboline alkaloids from Dicorynia guianensis Amsh heartwood

The role of extractives in the natural durability of the heartwood of Dicorynia guianensis Amsh: new insights in antioxydant and antifungal properties

“…The different filtrates were evaporated on Rotavapor® (Flawil, Switzerland) under vacuum at 40°C and resulted respectively to fraction FI, fraction FII, fraction FIII, fraction FIV, and fraction FV. The residual water fraction is lyophilized to give fraction FVI (Anouhe et al 2015). An amount of 3100 mg of fraction FII is chromatographed over a column of silica gel 60 (Merck, 230-400 mesh).…”

“…Wood production's activities generate large amounts of biomass residues (sawdust, wood chips, and barks) which are left in the field or burned for energy production (Berlioz 2012). Recent studies have reported the antiradical capability of alkaloids fractions from its heartwood (Anouhe et al 2015).…”

Two‐in‐One Strategy for Palladium‐Catalyzed C−H Functionalization in Water

“…Deuterium-labeling experiments are discussed to provide insight into the mechanism. Examples include Komavine (1)( and Acetylkomavine), [4] Spiroindolone (2), [5] Tabertinggine (3), [6] Peharmaline A( 4), [7] Subincanadine B(5), [8] and the antimalarial drug NITD609 (6). As only aminute difference in reactivity exists between various CÀHb onds,r egioselective activation of these CÀHb onds constitutes ag reat challenge.T os olve such ap roblem, ad irecting group can help to direct the catalyst to activate proximal C À Hb onds via cyclometallated intermediates.However,the directing group needs to be preinstalled in the substrate and, upon finishing its mission, it is usually hard to remove from the product (Scheme 1a).…”

“…[3] Forg reener and more atom-economical transformations,a s well as taking into consideration the difficulty in separating the reversibly linked directing group from the product, the development of a" two-in-one" strategy for C À Hf unctionalization, in which the transient directing group is also used as ar eagent to react with the activated CÀHb ond, is highly attractive.Thetetrahydro-b-carboline skeleton bearing aquaternary carbon center at C1 is an important framework in natural products and pharmaceutical agents (Figure 1). Examples include Komavine (1)( and Acetylkomavine), [4] Spiroindolone (2), [5] Tabertinggine (3), [6] Peharmaline A( 4), [7] Subincanadine B(5), [8] and the antimalarial drug NITD609 (6). [9] Herein, based on the two-in-one strategy,w er eport ap alladium-catalyzed CÀHb ond activation at C2 of indole and pyridine in water followed by cyclization with at ransient directing group (imine group) to form the C À Cb ond.…”

“…Thetetrahydro-b-carboline skeleton bearing aquaternary carbon center at C1 is an important framework in natural products and pharmaceutical agents ( Figure 1). Examples include Komavine (1)( and Acetylkomavine), [4] Spiroindolone (2), [5] Tabertinggine (3), [6] Peharmaline A( 4), [7] Subincanadine B(5), [8] and the antimalarial drug NITD609 (6). [9] Herein, based on the two-in-one strategy,w er eport ap alladium-catalyzed CÀHb ond activation at C2 of indole and pyridine in water followed by cyclization with at ransient directing group (imine group) to form the C À Cb ond.…”