Higher Levels of Serum 25-Hydroxyvitamin D Are Related to Improved Glucose Homeostasis in Women with Postmenopausal Osteoporosis

Ávila-Rubio, Verónica; García-Fontana, Beatriz; Novo-Rodriguez, Cristina; Cantero-Hinojosa, J.; Reyes-García, Rebeca; Muñóz-Torres, Manuel

doi:10.1089/jwh.2017.6806

Cited by 5 publications

(6 citation statements)

References 36 publications

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“…They proposed a target 25(OH)D of 50 ng/mL; higher than the levels previously suggested in other studies, in the attempt to influence and reduce the incidence rate of diabetes [36]. These data are consistent with the levels published recently by Avila-Rubio et al in postmenopausal women, the authors link values of 25(OH)D > 45 ng/dL in these women with better glycemic indexes measured by homeostasis model assessment (HOMA) [37].…”

Section: Vitamin D and Type 2 Diabetes (T2d)supporting

confidence: 87%

“…Von Horst et al found that optimal 25OHD concentrations for reducing IR were around 50 ng/dL in a randomized controlled study with 81 Asian women [49]. Avila Rubio et al [37], in a study conducted in women with postmenopausal osteoporosis, suggested that the established goal of reaching a level of 25(OH)D > 30 ng/mL was insufficient to improve glucose metabolism in these population. The data from this study indicates that 25(OH)D > 45 ng/mL are necessary to achieve this goal.…”

Section: Vitamin D and Type 2 Diabetes (T2d)mentioning

confidence: 99%

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Vitamin D Status, Calcium Intake and Risk of Developing Type 2 Diabetes: An Unresolved Issue

2019

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The relationship between vitamin D status, calcium intake and the risk of developing type 2 diabetes (T2D) is a topic of growing interest. One of the most interesting non-skeletal functions of vitamin D is its potential role in glucose homeostasis. This possible association is related to the secretion of insulin by pancreatic beta cells, insulin resistance in different tissues and its influence on systemic inflammation. However, despite multiple observational studies and several meta-analyses that have shown a positive association between circulating 25-hydroxyvitamin D concentrations and the risk of T2D, no randomized clinical trials supplementing with different doses of vitamin D have confirmed this hypothesis definitively. An important question is the identification of what 25-hydroxyvitamin D levels are necessary to influence glycemic homeostasis and the risk of developing T2D. These values of vitamin D can be significantly higher than vitamin D levels required for bone health, but the currently available data do not allow us to answer this question adequately. Furthermore, a large number of observational studies show that dairy consumption is linked to a lower risk of T2D, but the components responsible for this relationship are not well established. Therefore, the importance of calcium intake in the risk of developing T2D has not yet been established. Although there is a biological plausibility linking the status of vitamin D and calcium intake with the risk of T2D, well-designed randomized clinical trials are necessary to answer this important question.

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Section: Vitamin D and Type 2 Diabetes (T2d)supporting

confidence: 87%

Section: Vitamin D and Type 2 Diabetes (T2d)mentioning

confidence: 99%

Vitamin D Status, Calcium Intake and Risk of Developing Type 2 Diabetes: An Unresolved Issue

2019

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“…A 29-year prospective cohort study including 9841 participants, it was found higher risk for T2D development (OR: 1.5 95% CI 1.33-1.70) in the subjects with 25(OH)D levels in the lowest quartile (<5 ng/mL) compared to those in the highest quartile (≥20 ng/mL) [95]. The study of Avila-Rubio et al reported better glycaemia indices measured by the HOMA in postmenopausal women with 25(OH)D values > 45 ng/dL without established disturbances in glucose metabolism compared to those below [98]. These data are consistent with those of Park et al [99], showing an inverse dose-response association between 25(OH)D level and the diabetes risk.…”

Section: Vitamin D Status and T2dmentioning

confidence: 98%

“…However, the potential benefits of higher values to achieve extra-osseous benefits is a question currently under investigation [109]. Avila-Rubio et al suggested that the stated goal of achieving a 25(OH)D level > 30 ng/mL was insufficient to improve glucose metabolism in women with postmenopausal osteoporosis, proposing an optimal level of 45 ng/mL to achieve effects on these targets [98]. Von Horst et al reported an optimal 25(OH)D concentrations around 50 ng/mL for reducing insulin resistance in Asian women [110].…”

Section: Vitamin D Supplementation and T2dmentioning

confidence: 99%

Mechanisms Involved in the Relationship between Vitamin D and Insulin Resistance: Impact on Clinical Practice

Contreras-Bolívar

García-Fontana

et al. 2021

Nutrients

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Recent evidence has revealed anti-inflammatory properties of vitamin D as well as extra-skeletal activity. In this context, vitamin D seems to be involved in infections, autoimmune diseases, cardiometabolic diseases, and cancer development. In recent years, the relationship between vitamin D and insulin resistance has been a topic of growing interest. Low 25-hydroxyvitamin D (25(OH)D) levels appear to be associated with most of the insulin resistance disorders described to date. In fact, vitamin D deficiency may be one of the factors accelerating the development of insulin resistance. Vitamin D deficiency is a common problem in the population and may be associated with the pathogenesis of diseases related to insulin resistance, such as obesity, diabetes, metabolic syndrome (MS) and polycystic ovary syndrome (PCOS). An important question is the identification of 25(OH)D levels capable of generating an effect on insulin resistance, glucose metabolism and to decrease the risk of developing insulin resistance related disorders. The benefits of 25(OH)D supplementation/repletion on bone health are well known, and although there is a biological plausibility linking the status of vitamin D and insulin resistance supported by basic and clinical research findings, well-designed randomized clinical trials as well as basic research are necessary to know the molecular pathways involved in this association.

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“…Ei au propus o concentrație țintă pentru 25 (OH) D de 50 ng/ml, mult mai mare decât concentrațiile sugerate în alte studii, în încercarea de a influența și de a reduce rata apariției DZ [46]. Aceste date sunt în concordanță cu concentrațiile publicate de Avila-Rubio și colaboratorii la femeile aflate în postmenopauză, autorii observând că valori ale 25 (OH) D mai mari de 45 ng/dl la aceste femei se asociază cu indice glicemic bun [47].…”

Section: Roluri Fiziologice Ale Vitaminei Dunclassified

Vitamin D deficiency and insulin resistance

Miricescu¹,

Totan²,

Stănescu³

et al. 2019

Ro J Med Pract.

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RezumatVitamina D (colecalciferolul) este activă în organismul uman în urma a două reacții de hidroxilare. Odată activată, este implicată în metabolismul osos, dar mai poate influența și alte procese biologice precum creșterea și proliferarea celulară sau angiogeneza. Studii realizate până în prezent sugerează o legătură între deficiența de vitamină D și rezistența la insulină. Scopul acestui review este de a analiza efectele hipovitaminozei D, dar și ale administrării de suplimente bogate în vitamină D asupra rezistenței la insulină, prin intermediul datelor furnizate de literatura de specialitate. AbstractVitamin D or cholecalciferol is active in the human body after two hydroxylation reactions. Once activated, it is involved in bone metabolism, but can also influence other biological processes such as cell growth and proliferation or angiogenesis. Studies conducted so far suggest a link between vitamin D deficiency and insulin resistance. The purpose of this review is to analyze the effects of hypovitaminosis D as well as the administration of vitamin D rich supplements on the insulin resistance provided by the specialized literature.

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Higher Levels of Serum 25-Hydroxyvitamin D Are Related to Improved Glucose Homeostasis in Women with Postmenopausal Osteoporosis

Abstract: Our results support the hypothesis that circulating 25(OH)D levels are related to improved glucose homeostasis in women with PMO. However, this relationship was apparent only in the presence of high circulating levels of 25(OH)D.

Cited by 5 publications

References 36 publications

Vitamin D Status, Calcium Intake and Risk of Developing Type 2 Diabetes: An Unresolved Issue

Vitamin D Status, Calcium Intake and Risk of Developing Type 2 Diabetes: An Unresolved Issue

Mechanisms Involved in the Relationship between Vitamin D and Insulin Resistance: Impact on Clinical Practice

Vitamin D deficiency and insulin resistance

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