Vitamin D Status, Calcium Intake and Risk of Developing Type 2 Diabetes: An Unresolved Issue

Muñoz-Garach, Araceli; García-Fontana, Beatriz; Muñóz-Torres, Manuel

doi:10.3390/nu11030642

Cited by 65 publications

(55 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, we cannot exclude that, in the studied women, such significant changes in 25(OH)D concentrations after the intervention were related to changes in CTX levels via the modification of energy profile (we can assume that observing the reduction in fat mass). Other authors previously confirmed the associations of 25(OH)D concentrations with adiposity indices [18,19].…”

Section: Discussionsupporting

confidence: 55%

“…Calciotropic actions are related to bone mass regulation procedures. However, there is also evidence that vitamin D, through vitamin D receptors, plays an important role in many other tissues, including skeletal muscles [16] and adipose tissue [17], and in the regulation of glucose and insulin homeostasis [18]. Moreover, low serum calcidiol (25(OH)D) concentrations, which express the body's vitamin D status, accompany many types of diseases e.g., cancer, cardiovascular disease, and metabolic and autoimmune disorders [19].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin D and Indices of Bone and Carbohydrate Metabolism in Postmenopausal Women Subjected to a 12-Week Aerobic Training Program—The Pilot Study

Nowak¹,

Dalz²,

Śliwicka³

et al. 2020

IJERPH

View full text Add to dashboard Cite

The purpose of this study was to assess the effect of Nordic walking training on the indices of bone and carbohydrate metabolism in relation to 25(OH)D levels in postmenopausal women that were subjected to the outdoor systematic physical activity. The study was performed in 10 postmenopausal women, who participated in a 12-week Nordic walking exercise program, taking place during spring months (March to June). Anthropometric and biochemical parameters were measured before and after the training program. Serum concentrations of 25-hydroksycholekalciferol (25(OH)D), parathyroid hormone (PTH), insulin, glucose, osteocalcin (OC), C-terminal telopeptide of type I collagen (CTX), and calcium were determined. After the Nordic walking exercise program, a significant increase in the serum levels of 25(OH)D and CTX and a decrease in body mass, body mass index (BMI), fat mass, and PTH concentrations were observed. The findings of the present study suggest that 25(OH)D, as important metabolic regulator, plays a role in the modification of bone markers’ responses after the outdoor training program, independent of the physical activity effects.

show abstract

Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Vitamin D and Indices of Bone and Carbohydrate Metabolism in Postmenopausal Women Subjected to a 12-Week Aerobic Training Program—The Pilot Study

Nowak¹,

Dalz²,

Śliwicka³

et al. 2020

IJERPH

View full text Add to dashboard Cite

show abstract

“…According to the results of SUCRA, vitamin D supplementation was the best for reducing FPG and improving HOMA-IR compared with the effects of the other nutritional strategies, and magnesium supplementation ranked second. Vitamin D, also known as calciferol, is mainly active in the body as 25-hydroxyvitamin D (25(OH)D), which is often used as the best indicator for measuring vitamin D levels [40]. Vitamin D deficiency is a common phenomenon after pregnancy; a study showed that at 25-28 weeks of gestation, the concentration of 25(OH)D in GDM patients is significantly reduced [41].…”

Section: Discussionmentioning

confidence: 99%

Effects of Nutritional Strategies on Glucose Homeostasis in Gestational Diabetes Mellitus: A Systematic Review and Network Meta-Analysis

Jin

Sha

Dong

et al. 2020

Journal of Diabetes Research

View full text Add to dashboard Cite

Background. Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy, and nutritional therapy is the basis of GDM treatment. However, the effects of different forms of nutritional supplementation on improving gestational diabetes are uncertain. Objective. We conducted a network meta-analysis to evaluate the effects of supplementation with different nutrients on glucose metabolism in women with GDM. Methods. We conducted a literature search using PubMed, EMBASE, and the Cochrane Library to identify randomized controlled trials (RCTs) comparing the differences between different nutritional strategies in women with GDM. The Cochrane tool was used to assess the risk of bias. Pairwise meta-analysis and network meta-analysis were used to compare and rank the effects of nutritional strategies for the improvement of fasting plasma glucose (FPG), serum insulin, and homeostasis model assessment-insulin resistance (HOMA-IR). Results. We included thirteen RCTs with a total of 754 participants. Compared with placebo, omega-3, magnesium, vitamin D, zinc, and probiotics were more beneficial for improving FPG, serum insulin, and HOMA-IR. Network analysis showed that vitamin D supplementation was superior to omega-3 (-3.64 mg/dL, 95% CI: -5.77 to -1.51), zinc (-5.71 mg/dL, 95% CI: -10.19 to -1.23), probiotics (-6.76 mg/dL, 95% CI: -10.02 to -3.50), and placebo (-12.13 mg/dL, 95% CI: -14.55 to -9.70) for improving FPG. Magnesium supplementation was more beneficial for decreasing serum insulin compared with probiotics (-5.10 μIU/mL, 95% CI: -9.32 to -0.88) and placebo (-7.80 μIU/mL; 95% CI-11.95, -3.65). Vitamin D was more effective than probiotics (-0.99, 95% CI: -1.84 to -0.14) and placebo (-1.80, 95% CI: -2.45 to -1.16) for improving HOMA-IR. Conclusion. Vitamin D supplementation significantly reduced FPG and regulated HOMA-IR. Magnesium supplementation was superior in decreasing serum insulin than supplementation with other nutrients. Nutrient supplementation seemed to have an effect on glucose homeostasis maintenance in patients with GDM and may be considered an adjunctive therapy.

show abstract

“…However, the effect of calcium supplementation on MetS remains poorly established. 24 The conflicting results for calcium supplementation, which appears to decrease the level of insulin resistance and increase the serum calcium levels, appears to be associated with a higher level of insulin resistance, implying a more complex pathomechanism than that only merely reflected by the serum calcium levels.…”

Section: Discussionmentioning

confidence: 99%

<p>Calcium and Phosphate Levels are Among Other Factors Associated with Metabolic Syndrome in Patients with Normal Weight</p>

Osadnik¹,

Osadnik²,

Delijewski³

et al. 2020

DMSO

View full text Add to dashboard Cite

Background and Purpose: We aimed to assess the association between calcium and phosphorous and metabolic syndrome (MetS) in normal-weight individuals. Patients and Methods: The study sample comprised 460 normal-weight (body mass index <25kg/m 2) adults aged 18-35 years. The diagnosis of MetS was based on the presence of at least two of the following: 1) systolic blood pressure (SBP) ≥130 mmHg or diastolic blood pressure (DBP) ≥85 mmHg, 2) triglycerides (TG) >150 mg/dl, 3) high-density lipoprotein cholesterol (HDL-C) <1 mmol/in men and <1.2 mmol/l in women, 4) total cholesterol (TC) >5.2 mmol/l, and 5) fasting glucose (FBG) >5.55 mmol/l. Results: Patients with MetS were more often male and slightly older and they had a higher body mass index (BMI) and waist circumference. By definition, patients with MetS had higher levels of BP, GLC, glycated hemoglobin A1c, TC, low-density lipoprotein cholesterol (LDL-C), TG, and apolipoprotein B but significantly lower concentrations of HDL-C and apolipoprotein A. Moreover, subjects with MetS had higher activity of the liver enzymes alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transpeptidase (GGTP). Higher concentrations of uric acid, creatinine and albumin (ALB) were also observed in subjects with MetS. The factors associated with MetS in the multivariate analysis were higher GGTP activity (OR per 5 unit increase-1.23 (1.11-1.37); p<0.0001), a higher BMI (OR-1.28 (1.1-1.52); p=0.003), a higher concentration of calcium (OR per 0.1 mmol/l increase-1.79 (1.21-2.7); p=0.004), higher ALB levels (OR per 5 g/l increase-1.76 (1.11-2.95), p=0.02); higher phosphorous levels (OR per 0.1 mmol/l increase-0.82 (0.67-0.99); p=0.04), and a good household situation (odds ratio (OR)-0.58 95% confidence interval (CI) (0.31-1.07); p=0.08). Conclusion: Calcium and phosphorus levels are significantly associated with MetS in normal-weight individuals.

show abstract

Vitamin D Status, Calcium Intake and Risk of Developing Type 2 Diabetes: An Unresolved Issue

Cited by 65 publications

References 88 publications

Vitamin D and Indices of Bone and Carbohydrate Metabolism in Postmenopausal Women Subjected to a 12-Week Aerobic Training Program—The Pilot Study

Vitamin D and Indices of Bone and Carbohydrate Metabolism in Postmenopausal Women Subjected to a 12-Week Aerobic Training Program—The Pilot Study

Effects of Nutritional Strategies on Glucose Homeostasis in Gestational Diabetes Mellitus: A Systematic Review and Network Meta-Analysis

<p>Calcium and Phosphate Levels are Among Other Factors Associated with Metabolic Syndrome in Patients with Normal Weight</p>

Contact Info

Product

Resources

About