High velocity pulse biopsy device enables controllable and precise needle insertion and high yield tissue acquisition

Abstract

Minimally invasive biopsies are a cornerstone of breast cancer management with ultrasound being the preferred guidance modality. New developments in breast cancer management and advances in imaging technologies bring new challenges to current biopsy methodologies. A new biopsy device (NeoNavia® biopsy system, 14 G) was developed. It incorporates a pneumatic needle insertion mechanism that is intended to provide better control of needle progression and enable stepwise insertion without noticeable deformation or displacement of surrounding tissue as visualized under ultrasound. A new method of tissue acquisition was designed to achieve a sampling yield higher than standard methodologies. Needle dynamics was assessed on a specifically designed test bed and sampling performance was compared to a Magnum® biopsy instrument (Bard, Covington, GA, USA) in representative tissue models. The histological quality of samples obtained ex-vivo was evaluated. A pneumatic pulse was measured to accelerate the needle to a maximum velocity of 21.2 ± 2.5 m/s on a stroke length of 2.5 mm, achieving significantly higher acceleration, maximum velocity and power than current biopsy devices. Mean weight of samples obtained by the NeoNavia device were 3.5, 4.6, and 4.3 times higher when sampling was performed in turkey breast, calf thymus and swine pancreas, respectively, as compared to samples obtained with the Magnum instrument. Ex-vivo analysis indicates that the method of tissue acquisition has no apparent negative impact on the histopathologic quality of obtained samples.

Increased breast cancer mortality due to treatment delay and needle biopsy type: a retrospective analysis of SEER-medicare

“…Both CNB and VAB utilize various needle sizes, ranging from as small as 14-gauge (2 mm) to 8-gauge (4.1 mm) [ 20 ]. CNB is typically performed with a high-speed, spring-loaded biopsy device that yields a maximum velocity ranging from 8 to 21 m/s [ 43 ] and often requires multiple needle insertions, particularly for large lesions [ 20 , 21 ]. VAB draws adequate amounts of tissue through typically single insertion of a large-size needle using vacuum-created pressure differentials [ 44 ].…”

Biopsy with Side-Cutting Coaxial Needle—Knowing the “Cutting Length” and “Throw Length”

“…The coaxial technique allows the user to obtain multiple samples through a single puncture site while minimizing trauma to surrounding tissues. 7,8 Definitions of Biopsy Needle Geometry (►Fig. 2)…”

Intraradiological pathology‐calibrated electrical impedance spectroscopy in the evaluation of excision‐required breast lesions

“…There are many advanced techniques to increase the biopsy result accuracy, such as stereotactic biopsy, 15–17 ultrasound elastography, 18,19 multiparametric magnetic resonance imaging/transrectal ultrasound (MRI/TRUS) fusion biopsy, 20 contrast‐enhanced MRI, 21 and high‐velocity pulse biopsy, 22 which are primarily complicated and expensive.…”

“…11 Also, a precise selection of vital neoplastic regions to take an accurate biopsy is crucial in large heteroge-nous masses, which could directly affect the pathological evaluations. 2,[12][13][14] There are many advanced techniques to increase the biopsy result accuracy, such as stereotactic biopsy, [15][16][17] ultrasound elastography, 18,19 multiparametric magnetic resonance imaging/transrectal ultrasound (MRI/TRUS) fusion biopsy, 20 contrast-enhanced MRI, 21 and highvelocity pulse biopsy, 22 which are primarily complicated and expensive.…”